{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:56:56Z","timestamp":1783612616320,"version":"3.55.0"},"reference-count":10,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Adrenaline (epinephrine) is included in dental local anesthesia for the purpose of vasoconstriction. In Japan, adrenaline is contraindicated for use in patients receiving antipsychotic therapy, because the combination of adrenaline and an antipsychotic is considered to cause severe hypotension; however, there is insufficient evidence supporting this claim. The purpose of the present study was to clarify the changes in hemodynamics caused by drug interaction between adrenaline and an antipsychotic and to evaluate the safety of the combined use of adrenaline and an antipsychotic in an animal study. Male Sprague-Dawley rats were anesthetized with sodium pentobarbital. A catheter was inserted into the femoral artery to measure blood pressure and pulse rate. Rats were pretreated by intraperitoneal injection of chlorpromazine or chlorpromazine and propranolol, and after 20 minutes, saline or 1 of 3 different doses of adrenaline was administered by intraperitoneal injection. Changes in the ratio of mean arterial blood pressure and pulse rate were measured after the injection of adrenaline. Significant hypotension and tachycardia were observed after the injection of adrenaline in the chlorpromazine-pretreated rats. These effects were in a dose-dependent manner, and 100 \u03bcg\/kg adrenaline induced significant hemodynamic changes. Furthermore, in the chlorpromazine and propranolol\u2013pretreated rats, modest hypertension was induced by adrenaline, but hypotension and tachycardia were not significantly shown. Hypotension was caused by a drug interaction between adrenaline and chlorpromazine through the activation of the \u03b2-adrenergic receptor and showed a dose-dependent effect. Low-dose adrenaline similar to what might be used in human dental treatment did not result in a significant homodynamic change.<\/jats:p>","DOI":"10.2344\/0003-3006-61.4.150","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T09:07:49Z","timestamp":1418893669000},"page":"150-154","source":"Crossref","is-referenced-by-count":9,"title":["Hemodynamic Changes by Drug Interaction of Adrenaline With Chlorpromazine"],"prefix":"10.2344","volume":"61","author":[{"given":"Hitoshi","family":"Higuchi","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yabuki","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Ishii-Maruhama","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Tomoyasu","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i0003-3006-61-4-150-b01","series-title":"St Louis, Mo: Elsevier Mosby;","first-page":"149","article-title":"Handbook of Local Anesthesia. 5th ed","volume":"41","author":"Malamed\n              SF.","year":"2004","unstructured":"Malamed\n              SF. \n          \n          Handbook of Local Anesthesia. 5th ed. St Louis, Mo: Elsevier Mosby;2004:41, 149\u2013151."},{"key":"i0003-3006-61-4-150-b02","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"401","article-title":"Epinephrine and local anesthesia revisited","volume":"100","author":"Brown\n              RS,","year":"2005","unstructured":"Brown\n              RS, \n            \n              Rhodus\n              NL. \n          \n          Epinephrine and local anesthesia revisited. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:401\u2013408."},{"key":"i0003-3006-61-4-150-b03","series-title":"Lancet","first-page":"635","article-title":"Schizophrenia","volume":"374","author":"van Os\n              J,","year":"2009","unstructured":"van Os\n              J, \n            \n              Kapur\n              S. \n          \n          Schizophrenia. Lancet. 2009;374:635\u2013645."},{"key":"i0003-3006-61-4-150-b04","first-page":"32","article-title":"WHO: The global burden of disease 2004 update","year":"2008","unstructured":"WHO: The global burden of disease 2004 update. Geneva, Switzerland: World Health Organization; 2008:32. Available at: http:\/\/www.who.int\/healthinfo\/global_burden_disease\/GBD_report_2004update_full.pdf. Accessed November 20, 2013."},{"key":"i0003-3006-61-4-150-b05","series-title":"Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed","first-page":"220","author":"Hardman\n              JG,","year":"2001","unstructured":"Hardman\n              JG, \n            \n              Limbird\n              LE. \n          \n          Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw Hill;2001:220\u2013222, 485, 495."},{"key":"i0003-3006-61-4-150-b06","series-title":"Lancet","first-page":"31","article-title":"Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis","volume":"373","author":"Leucht\n              S,","year":"2009","unstructured":"Leucht\n              S, \n            \n              Corves\n              C, \n            \n              Arbter\n              D, \n            \n              Engel\n              RR, \n            \n              Li\n              C, \n            \n              Davis\n              JM. \n          \n          Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373:31\u201341."},{"key":"i0003-3006-61-4-150-b07","series-title":"Ann Intern Med","first-page":"498","article-title":"Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis","volume":"157","author":"Hartling\n              L,","year":"2012","unstructured":"Hartling\n              L, \n            \n              Abou-Setta\n              AM, \n            \n              Dursun\n              S, \n            \n              Mousavi\n              SS, \n            \n              Pasichnyk\n              D, \n            \n              Newton\n              AS. \n          \n          Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis. Ann Intern Med. 2012;157:498\u2013511."},{"key":"i0003-3006-61-4-150-b08","series-title":"Lancet","first-page":"614","article-title":"Chlorpromazine: a study of its action on the circulation in man","volume":"267","author":"Foster\n              CA,","year":"1954","unstructured":"Foster\n              CA, \n            \n              O'Mullane\n              EJ, \n            \n              Gaskell\n              P, \n            \n              Churchill-Davidson\n              HC. \n          \n          Chlorpromazine: a study of its action on the circulation in man. Lancet. 1954;267:614\u2013617."},{"key":"i0003-3006-61-4-150-b09","series-title":"Br J Pharmacol Chemother","first-page":"180","article-title":"Effect of chlorpromazine on adrenaline vasoconstriction in man","volume":"11","author":"Ginsburg\n              J,","year":"1956","unstructured":"Ginsburg\n              J, \n            \n              Duff\n              RS. \n          \n          Effect of chlorpromazine on adrenaline vasoconstriction in man. Br J Pharmacol Chemother. 1956;11:180\u2013185."},{"key":"i0003-3006-61-4-150-b10","series-title":"Oral Surg Oral Med Oral Pathol","first-page":"565","article-title":"Drug interactions and vasoconstrictors used in local anesthetic solutions","volume":"59","author":"Yagiela\n              JA,","year":"1985","unstructured":"Yagiela\n              JA, \n            \n              Duffin\n              SR, \n            \n              Hunt\n              LM. \n          \n          Drug interactions and vasoconstrictors used in local anesthetic solutions. Oral Surg Oral Med Oral Pathol. 1985;59:565\u2013571."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/61\/4\/article-p150.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/61\/4\/150\/2101911\/0003-3006-61_4_150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/61\/4\/article-p150.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/61\/4\/article-p150.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:35:11Z","timestamp":1728304511000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/61\/4\/article-p150.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":10,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2344\/0003-3006-61.4.150","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"value":"0003-3006","type":"print"},{"value":"1878-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}