{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:17:11Z","timestamp":1778321831511,"version":"3.51.4"},"reference-count":18,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to compare the efficacy of dexamethasone alone and dexamethasone-ondansetron combined for preventing postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients scheduled to undergo mandibular orthognathic surgery who were 18 to 50 years of age and American Society of Anesthesiologists physical status I or II were enrolled. Dexamethasone 6.6 mg was administered after intubation, followed by either ondansetron 4 mg (group DO) or saline placebo (group D) 15 minutes before the end of surgery. Nausea severity was assessed at 3 times postoperatively (immediately after the end of anesthesia, 2 hours later, and 24 hours later) using a 11-point numeric rating scale (NRS). If a patient complained of postoperative nausea or vomited, the NRS score was reevaluated. If the NRS score was 3 or higher, intravenous metoclopramide 10 mg was administered for PONV rescue. Assessed data included nausea NRS scores, vomiting, metoclopramide use, and other patient demographics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Mean nausea NRS scores at 2 hours were significantly lower in group DO vs group D (0.3 vs 2.1; <jats:italic>P<\/jats:italic> = .003), but differences in vomiting rates were not significant (<jats:italic>P<\/jats:italic> &gt; .05). PONV rescue rates with metoclopramide were lower overall and at 2 hours later in group DO (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Dexamethasone combined with ondansetron was more effective in preventing early postoperative nausea and reducing need for PONV rescue than dexamethasone alone for patients undergoing orthognathic surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2344\/23-0019","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:02:28Z","timestamp":1742860948000},"page":"3-8","source":"Crossref","is-referenced-by-count":5,"title":["Dexamethasone and Ondansetron Combined Decreases Postoperative Nausea and Vomiting in Orthognathic Surgery Compared With Dexamethasone Alone: A Prospective Randomized Controlled Trial"],"prefix":"10.2344","volume":"72","author":[{"given":"Yuna","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyotaro","family":"Koshika","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Nakakuki","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Hasunuma","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maho","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"issue":"6","key":"i1878-7177-72-1-3-b01","series-title":"Int J Oral Maxillofac Surg","first-page":"745","article-title":"Postoperative nausea and vomiting following orthognathic surgery","volume":"44","author":"Philips C,","year":"2015","unstructured":"Philips C,\nBrookes CD,\nRich J,\nArbon J,\nTurvey TA. 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Anesth Analg. 1999;89(3):652-658."},{"key":"i1878-7177-72-1-3-b04","series-title":"F1000Res","first-page":"983","article-title":"Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an update review","volume":"9","author":"Elvir-Lazo OL,","year":"2020","unstructured":"Elvir-Lazo OL,\nWhite PF,\nYumul R,\nEng HC. Management strategies for the treatment and prevention of postoperative\/postdischarge nausea and vomiting: an update review. F1000Res. 2020;9:983."},{"key":"i1878-7177-72-1-3-b05","series-title":"J Oral Maxillofac Surg","first-page":"2207","article-title":"Corticosteroid administration in oral and orthognathic surgery: a systematic review of the literature and meta-analysis","volume":"68","author":"Dan AEB,","year":"2010","unstructured":"Dan AEB,\nThygesen TH,\nPinholt EM. Corticosteroid administration in oral and orthognathic surgery: a systematic review of the literature and meta-analysis. 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CNS Drugs. 2007;21(10):813-833."},{"issue":"3","key":"i1878-7177-72-1-3-b13","series-title":"Anesth Analg","first-page":"734","article-title":"Dexamethasone has a central antiemetic mechanism in decerebrated cats","volume":"99","author":"Ho CM,","year":"2004","unstructured":"Ho CM,\nHo ST,\nWang JJ,\nTsai SK,\nChai CY. Dexamethasone has a central antiemetic mechanism in decerebrated cats. Anesth Analg. 2004;99(3):734-739."},{"issue":"6","key":"i1878-7177-72-1-3-b14","series-title":"J Clin Anesth","first-page":"453","article-title":"Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo controlled multicenter trial","volume":"11","author":"Kovac AL,","year":"1999","unstructured":"Kovac AL,\nO`Connor TA,\nPearman MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo controlled multicenter trial. 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Can J Anaesth. 2000;47(6):537-551."},{"issue":"4","key":"i1878-7177-72-1-3-b17","series-title":"J Jpn Dent Soc Anesthesiol","first-page":"149","article-title":"A case of extrapyramidal symptoms developing after the administration of dopamine receptor antagonist. Article in Japanese","volume":"50","author":"Yajima K,","year":"2022","unstructured":"Yajima K,\nKang Y,\nSeki M,\nKoshika K,\nIchinohe T. A case of extrapyramidal symptoms developing after the administration of dopamine receptor antagonist. Article in Japanese. J Jpn Dent Soc Anesthesiol. 2022;50(4):149-151."},{"issue":"5","key":"i1878-7177-72-1-3-b18","series-title":"Anesth Analg","first-page":"1374","article-title":"Extrapyramidal reactions to ondansetron: cross-reactivity between ondansetron and prochlorperazine","volume":"96","author":"Sprung J,","year":"2003","unstructured":"Sprung J,\nChoudhry FM,\nHall BA. Extrapyramidal reactions to ondansetron: cross-reactivity between ondansetron and prochlorperazine? Anesth Analg. 2003;96(5):1374-1376."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/1\/article-p3.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/1\/article-p3.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/1\/article-p3.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:02:46Z","timestamp":1742860966000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/1\/article-p3.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":18,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2344\/23-0019","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}