{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T01:10:13Z","timestamp":1733274613307,"version":"3.30.1"},"reference-count":33,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Hypomelanosis of Ito (HI), a neurocutaneous syndrome, is characterized by skin depigmentation and skeletal, muscular, central nervous system, cardiac, and renal manifestations. A wide variety of cutaneous manifestations besides depigmentation have been reported. Herein we describe a 23-year-old woman with HI whose extracutaneous symptoms included severe mental and motor impairment, convulsions, and deformity of the orofacial region. She also had severe obesity, asthma, multiple allergies, and skin hypersensitivity. Although no extracutaneous manifestations were problematic during perioperative management of dental procedures under general anesthesia, erythema developed at 3 time points: during induction, during emergence, and in recovery. We speculated that mechanical stimuli to the skin and administration of multiple drugs likely caused histamine release, leading to the 3 episodes of erythema. Because patients with HI often have hypersensitivity reactions in the skin, both cutaneous and extracutaneous manifestations should be considered in the anesthetic management of patients with HI.<\/jats:p>","DOI":"10.2344\/23-0025","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:30:31Z","timestamp":1733272231000},"page":"188-193","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Abnormal Cutaneous Findings in a Patient With Hypomelanosis of Ito Undergoing General Anesthesia"],"prefix":"10.2344","volume":"71","author":[{"given":"Misato","family":"Kobashi","sequence":"first","affiliation":[{"name":"Division of Pediatric Dentistry, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyo","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako","family":"Ohke","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomasa","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaho","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisei","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Health Sciences University of Hokkaido Hospital, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Terumitsu","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i1878-7177-71-4-188-b01","series-title":"Handbook of Clinical Neurology, Neurocutaneous Syndromes","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-444-62702-5.00021-4","article-title":"Hypomelanosis of Ito","volume":"132","author":"Ream M.","year":"2015","unstructured":"Ream M. Hypomelanosis of Ito. In: \nIslam MP and Roach ES, eds. Handbook of Clinical Neurology, Neurocutaneous Syndromes, Vol. 132 (3rd series). Elsevier B.V; 2015;281\u2013289."},{"key":"i1878-7177-71-4-188-b02","series-title":"Brain Dev","first-page":"36","article-title":"Hypomelanosis of ITO. A study of 76 infantile cases","volume":"20","author":"Castroviejo IP,","year":"1998","unstructured":"Castroviejo IP,\nRoche C,\nBermejo AM, et al. Hypomelanosis of ITO. A study of 76 infantile cases. Brain Dev. 1998;20:36\u201343."},{"key":"i1878-7177-71-4-188-b03","series-title":"Can J Neurol Sci","first-page":"124","article-title":"Hypomelanosis of Ito. Neurological complications in 34 cases","volume":"15","author":"Castroviejo IP,","year":"1988","unstructured":"Castroviejo IP,\nRodriguez LL,\nde la Cruz Medina M,\nMaesso CS,\nHerrero C. Hypomelanosis of Ito. Neurological complications in 34 cases. Can J Neurol Sci. 1988;15:124\u2013129."},{"key":"i1878-7177-71-4-188-b04","series-title":"Sudan J Paediatr","first-page":"61","article-title":"The neurologic aspects of hypomelanosis of Ito: case report and review of the literature","volume":"14","author":"Kentab AY,","year":"2014","unstructured":"Kentab AY,\nHassan HH,\nHamad MHA,\nAlhumidi A. The neurologic aspects of hypomelanosis of Ito: case report and review of the literature. Sudan J Paediatr. 2014;14:61\u201370."},{"issue":"1","key":"i1878-7177-71-4-188-b05","series-title":"J Med Case Rep","first-page":"156","article-title":"Hypomelanosis of Ito presenting with pediatric orthopedic issues: a case report","volume":"8","author":"Tr\u00e4g\u00e5rdh M,","year":"2014","unstructured":"Tr\u00e4g\u00e5rdh M,\nThomsen CR,\nThorninger R,\nMadsen BM. Hypomelanosis of Ito presenting with pediatric orthopedic issues: a case report. J Med Case Rep. 2014;8(1):156."},{"key":"i1878-7177-71-4-188-b06","series-title":"Eur J Dermatol","first-page":"217","article-title":"Sweat testing in hypomelanosis of Ito: divergent results reflecting genetic heterogeneity","volume":"10","author":"Steijlen PM,","year":"2000","unstructured":"Steijlen PM,\nVi\u00ebtor HE,\nSteensel MV,\nHapple R. Sweat testing in hypomelanosis of Ito: divergent results reflecting genetic heterogeneity. Eur J Dermatol. 2000;10:217\u2013219."},{"key":"i1878-7177-71-4-188-b07","series-title":"J Med Assoc Thai","first-page":"253","article-title":"Incontinentia pigmenti achromians of Ito: an ultrastructural study","volume":"89","author":"Palungwachira P,","year":"2006","unstructured":"Palungwachira P,\nPalungwachira P. Incontinentia pigmenti achromians of Ito: an ultrastructural study. J Med Assoc Thai. 2006;89:253\u2013257."},{"key":"i1878-7177-71-4-188-b08","series-title":"J Dermatol Sci","first-page":"87","article-title":"Hypomelanosis of Ito: electron microscopical observations on two new cases","volume":"13","author":"Cavallari V,","year":"1996","unstructured":"Cavallari V,\nUssia AF,\nSiragusa M,\nSchepis C. Hypomelanosis of Ito: electron microscopical observations on two new cases. J Dermatol Sci. 1996;13:87\u201392."},{"key":"i1878-7177-71-4-188-b09","series-title":"Tohoku J Exp Med","first-page":"1","article-title":"Studies on melanin","volume":"55","author":"Ito M.","year":"1952","unstructured":"Ito M. Studies on melanin. Tohoku J Exp Med. 1952;55:1\u2013104."},{"key":"i1878-7177-71-4-188-b10","series-title":"J Child Neurol","first-page":"635","article-title":"Hypomelanosis of Ito: clinical syndrome or just phenotype","volume":"15","author":"Ruggieri M,","year":"2000","unstructured":"Ruggieri M,\nPavone L. Hypomelanosis of Ito: clinical syndrome or just phenotype? J Child Neurol. 2000;15:635\u2013644."},{"key":"i1878-7177-71-4-188-b11","series-title":"Clin Med Res","first-page":"16","article-title":"Flushing disorders associated with gastrointestinal symptoms: Part 1, neuroendocrine tumors, mast cell disorders and hyperbasophila","volume":"16","author":"Rastogi V,","year":"2018","unstructured":"Rastogi V,\nSingh D,\nMazza JJ,\nParajuli D,\nYale SH. Flushing disorders associated with gastrointestinal symptoms: Part 1, neuroendocrine tumors, mast cell disorders and hyperbasophila. Clin Med Res. 2018;16:16\u201328."},{"issue":"6","key":"i1878-7177-71-4-188-b12","series-title":"Med Princ Pract","first-page":"501","article-title":"Allergy, anaphylaxis, and nonallergic hypersensitivity: IgE, mast cells, and beyond","volume":"31","author":"Vitte J,","year":"2022","unstructured":"Vitte J,\nVibhushan S,\nBratti M,\nMontero-Hernandez JE,\nBlank U. Allergy, anaphylaxis, and nonallergic hypersensitivity: IgE, mast cells, and beyond. Med Princ Pract. 2022;31(6):501\u2013515."},{"key":"i1878-7177-71-4-188-b13","series-title":"Clin Med Res","first-page":"29","article-title":"Flushing disorders associated with gastrointestinal symptoms: Part 2, systemic miscellaneous conditions","volume":"16","author":"Rastogi V,","year":"2018","unstructured":"Rastogi V,\nSingh D,\nMazza JJ,\nParajuli D,\nYale SH. Flushing disorders associated with gastrointestinal symptoms: Part 2, systemic miscellaneous conditions. Clin Med Res. 2018;16:29\u201336."},{"key":"i1878-7177-71-4-188-b14","series-title":"J Auton Nerv Syst","first-page":"117","article-title":"Mechanisms of physiological gustatory sweating and flushing in the face","volume":"52","author":"Drummond PD.","year":"1995","unstructured":"Drummond PD. Mechanisms of physiological gustatory sweating and flushing in the face. J Auton Nerv Syst. 1995;52:117\u2013124."},{"issue":"1","key":"i1878-7177-71-4-188-b15","series-title":"Physiol Res","first-page":"113","article-title":"Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2","volume":"61","author":"Zhang D,","year":"2012","unstructured":"Zhang D,\nSpielmann A,\nWang L, et al. Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2. Physiol Res. 2012;61(1):113\u2013124."},{"issue":"11","key":"i1878-7177-71-4-188-b16","series-title":"J Invest Dermatol","first-page":"2210","article-title":"Critical signaling events in the mechanoactivation of human mast cells through p.C492Y-ADGRE2","volume":"140","author":"Naranjo AN,","year":"2020","unstructured":"Naranjo AN,\nBandara G,\nBai Y, et al. Critical signaling events in the mechanoactivation of human mast cells through p.C492Y-ADGRE2. J Invest Dermatol. 2020;140(11):2210\u20132220."},{"key":"i1878-7177-71-4-188-b17","series-title":"Front Immunol","first-page":"3027","article-title":"Mas-Related G-protein coupled receptor X2 (MRGPRX2) in drug hypersensitivity reactions","volume":"9","author":"Porebski G,","year":"2018","unstructured":"Porebski G,\nKwiecien K,\nPawica M,\nKwitniewski M. Mas-Related G-protein coupled receptor X2 (MRGPRX2) in drug hypersensitivity reactions. Front Immunol. 2018;9:3027."},{"key":"i1878-7177-71-4-188-b18","series-title":"Anaesthesia","first-page":"76","article-title":"Adverse drug reactions","volume":"73","author":"Patton K,","year":"2018","unstructured":"Patton K,\nBorshoff DC. Adverse drug reactions. Anaesthesia. 2018;73:76\u201384."},{"key":"i1878-7177-71-4-188-b19","series-title":"J Investig Allergol Clin Immunol","first-page":"442","article-title":"Reducing the risk of anaphylaxis during anesthesia. 2011 updated guidelines for clinical practice","volume":"21","author":"Mertes P,","year":"2011","unstructured":"Mertes P,\nMalinovsky J,\nJouffroy L, et al. Reducing the risk of anaphylaxis during anesthesia. 2011 updated guidelines for clinical practice. J Investig Allergol Clin Immunol. 2011;21:442\u2013453."},{"issue":"5","key":"i1878-7177-71-4-188-b20","series-title":"Br J Anaesth","first-page":"588","article-title":"Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine","volume":"75","author":"Naguib M,","year":"1995","unstructured":"Naguib M,\nSamarkandi AH,\nBakhamees HS,\nMagboul MA,\nel-Bakry AK. Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine. Br J Anaesth. 1995;75(5):588\u2013592."},{"key":"i1878-7177-71-4-188-b21","series-title":"Front Immunol","first-page":"676354","article-title":"MRGPRX2 and adverse drug reactions","volume":"12","author":"McNeil BD.","year":"2021","unstructured":"McNeil BD. MRGPRX2 and adverse drug reactions. Front Immunol. 2021;12:676354."},{"key":"i1878-7177-71-4-188-b22","series-title":"Nature","first-page":"237","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil BD,","year":"2015","unstructured":"McNeil BD,\nPundir P,\nMeeker S, et al. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 2015;519:237\u2013241."},{"key":"i1878-7177-71-4-188-b23","series-title":"Anesth Analg","first-page":"364","article-title":"Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin","volume":"98","author":"Blunk JA,","year":"2004","unstructured":"Blunk JA,\nSchmelz M,\nZeck S. Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin. Anesth Analg. 2004;98:364\u2013370."},{"key":"i1878-7177-71-4-188-b24","series-title":"Anesthesiology","first-page":"756","article-title":"Wheal and flare responses to opioids in humans","volume":"70","author":"Levy JH,","year":"1989","unstructured":"Levy JH,\nBrister NW,\nShearin A. Wheal and flare responses to opioids in humans. Anesthesiology. 1989;70:756\u2013760."},{"key":"i1878-7177-71-4-188-b25","series-title":"J Allergy Clin Immunol","first-page":"366","article-title":"Groupe d\u2019Etudes des R\u00e9actions Anaphylacto\u00efdes Peranesth\u00e9siques. Anaphylaxis during anesthesia in France: an 8-year national survey","volume":"128","author":"Mertes PM,","year":"2011","unstructured":"Mertes PM,\nAlla F,\nTr\u00e9chot P,\nAuroy Y,\nJougla E. Groupe d\u2019Etudes des R\u00e9actions Anaphylacto\u00efdes Peranesth\u00e9siques. Anaphylaxis during anesthesia in France: an 8-year national survey. J Allergy Clin Immunol. 2011;128:366\u2013373."},{"issue":"6","key":"i1878-7177-71-4-188-b26","series-title":"Br J Anaesth","first-page":"751","article-title":"General anaesthetics induce only histamine release selectively from human mast cells","volume":"67","author":"Stellato C,","year":"1991","unstructured":"Stellato C,\nCasolaro V,\nCiccarelli A,\nMastronardi P,\nMazzarella B,\nMarone G. General anaesthetics induce only histamine release selectively from human mast cells. Br J Anaesth. 1991;67(6):751\u2013758."},{"key":"i1878-7177-71-4-188-b27","series-title":"Inflamm Res","first-page":"582","article-title":"Histamine release during the induction of anesthesia with propofol in allergic patients: a comparison with the induction of anesthesia using midazolam-ketamine","volume":"48","author":"Kimura K,","year":"1999","unstructured":"Kimura K,\nAdachi M,\nKubo K. Histamine release during the induction of anesthesia with propofol in allergic patients: a comparison with the induction of anesthesia using midazolam-ketamine. Inflamm Res. 1999;48:582\u2013587."},{"key":"i1878-7177-71-4-188-b28","series-title":"Br J Anaesth","first-page":"758","article-title":"Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers","volume":"121","author":"de Kam PJ,","year":"2018","unstructured":"de Kam PJ,\nNolte H,\nGood S, et al. Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers. Br J Anaesth. 2018;121:758\u2013767."},{"key":"i1878-7177-71-4-188-b29","series-title":"Clin Exp Allergy","first-page":"1663","article-title":"Drug-specific cyclodextrins with emphasis on sugammadex, the neuromuscular blocker rocuronium and perioperative anaphylaxis: implications for drug allergy","volume":"41","author":"Baldo BA,","year":"2011","unstructured":"Baldo BA,\nMcDonnell NJ,\nPham NH. Drug-specific cyclodextrins with emphasis on sugammadex, the neuromuscular blocker rocuronium and perioperative anaphylaxis: implications for drug allergy. Clin Exp Allergy. 2011;41:1663\u20131678."},{"key":"i1878-7177-71-4-188-b30","series-title":"Pharm Res","first-page":"556","article-title":"Cyclodextrins: their future in drug formulation and delivery","volume":"14","author":"Stella VJ,","year":"1997","unstructured":"Stella VJ,\nRajewski RA. Cyclodextrins: their future in drug formulation and delivery. Pharm Res. 1997;14:556\u2013567."},{"key":"i1878-7177-71-4-188-b31","series-title":"J Anesth","first-page":"148","article-title":"A suspected case of rocuronium-sugammadex complex-induced anaphylactic shock after cesarean section","volume":"31","author":"Yamaoka M,","year":"2017","unstructured":"Yamaoka M,\nDeguchi M,\nNinomiya K,\nKurasako T,\nMatsumoto M. A suspected case of rocuronium-sugammadex complex-induced anaphylactic shock after cesarean section. J Anesth. 2017;31:148\u2013151."},{"key":"i1878-7177-71-4-188-b32","series-title":"Lancet","first-page":"183","article-title":"Antibiotic allergy","volume":"393","author":"Blumenthal KG,","year":"2019","unstructured":"Blumenthal KG,\nPeter JG,\nTrubiano JA,\nPhillips EJ. Antibiotic allergy. Lancet. 2019;393:183\u2013198."},{"issue":"3","key":"i1878-7177-71-4-188-b33","series-title":"Eur J Dermatol","first-page":"217","article-title":"Sweat testing in hypomelanosis of Ito: divergent results reflecting genetic heterogeneity","volume":"10","author":"Steijlen PM,","year":"2000","unstructured":"Steijlen PM,\nVi\u00ebtor HE,\nSteensel MV,\nHapple R. Sweat testing in hypomelanosis of Ito: divergent results reflecting genetic heterogeneity. Eur J Dermatol. 2000;10(3):217\u2013219."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/4\/article-p188.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/4\/article-p188.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/4\/article-p188.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:31:03Z","timestamp":1733272263000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/4\/article-p188.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":33,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2344\/23-0025","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}