{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:02:36Z","timestamp":1779850956777,"version":"3.53.1"},"reference-count":46,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the effects of remifentanil and remimazolam on the cardiovascular system, oral tissue blood flow, and oral tissue oxygen tension during general anesthesia in rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Japanese white rabbits (body weight, 2.5 kg; N = 11) were treated with remimazolam at a dose of 1 mg\/kg\/h continuously. Measurements included blood pressure, heart rate, tissue blood flow (common carotid artery, tongue mucosal, mandibular bone marrow and masseter muscle), and tissue oxygen tension (mandibular bone marrow and masseter muscle). Remifentanil was then administered at 0.2 \u03bcg\/kg\/min and each measurement was collected again. The dose of remifentanil was increased to 0.4 \u03bcg\/kg\/min and each measurement was collected again. The same measurements were collected when remimazolam was administered at doses of 2 mg\/kg\/h and 4 mg\/kg\/h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Remimazolam administration did not significantly alter the parameters of each observation. Blood pressure, heart rate, and tissue blood flow (common carotid artery, tongue mucosal, mandibular bone marrow, and masseter muscle) decreased significantly in a dose-rate dependent manner under remifentanil administration, whereas tissue oxygen tensions (mandibular bone marrow and masseter muscle) were maintained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Remimazolam anesthesia in rabbits had minimal effects, but in combination with remifentanil, it produced remifentanil dose-dependent decreases in oral tissue blood flow as well as blood pressure and heart rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2344\/23-0045","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:08:16Z","timestamp":1749445696000},"page":"80-89","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Remimazolam With or Without Remifentanil on Oral Tissue Blood Flow and Oxygen Tension in Rabbits"],"prefix":"10.2344","volume":"72","author":[{"given":"Kohei","family":"Shimazu","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyotaro","family":"Koshika","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i1878-7177-72-2-80-b01","series-title":"J Orthop Res","first-page":"1473","article-title":"Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials","volume":"14","author":"Jiang J","year":"2019","unstructured":"Jiang J,\nZhou R,\nLi B,\nXue F. Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials. J Orthop Res. 2019;14:1473\u22121476."},{"key":"i1878-7177-72-2-80-b02","series-title":"J R Coll Surg Edinb","first-page":"261","article-title":"Tooth extraction, bleeding and pain control","volume":"4","author":"Al-Bahlani S","year":"2001","unstructured":"Al-Bahlani S,\nSherriff A,\nCrawford PJM. Tooth extraction, bleeding and pain control. J R Coll Surg Edinb. 2001;4:261\u2212264."},{"key":"i1878-7177-72-2-80-b03","series-title":"Int J Oral Maxillofac Surg","first-page":"687","article-title":"Risks and benefits of deliberate hypotension in anaesthesia: a systematic review","volume":"37","author":"Choi WS","year":"2008","unstructured":"Choi WS,\nSamman N. Risks and benefits of deliberate hypotension in anaesthesia: a systematic review. Int J Oral Maxillofac Surg. 2008;37:687\u2212703."},{"key":"i1878-7177-72-2-80-b04","series-title":"Anesthesiology","first-page":"307","article-title":"Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery","volume":"123","author":"Monk TG","year":"2015","unstructured":"Monk TG,\nBronsert MR,\nHenderson WG, et al. Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery. Anesthesiology. 2015;123:307\u2212319."},{"key":"i1878-7177-72-2-80-b05","series-title":"J Vet Med Sci","first-page":"62","article-title":"Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow","volume":"83","author":"Kobayashi A","year":"2021","unstructured":"Kobayashi A,\nKasaghara M,\nAkiike Y,\nKoshika K,\nIchinohe T. Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow. J Vet Med Sci. 2021;83:62\u201368."},{"key":"i1878-7177-72-2-80-b06","series-title":"J Oral Maxillofac Surg","first-page":"2128","article-title":"Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits","volume":"69","author":"Koshika K","year":"2011","unstructured":"Koshika K,\nIchinohe T,\nKaneko Y. Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits. J Oral Maxillofac Surg. 2011;69:2128\u22122134."},{"key":"i1878-7177-72-2-80-b07","series-title":"Anesth Prog","first-page":"3","article-title":"Remifentanil reduces blood loss during orthognathic surgery","volume":"64","author":"Matsuura N","year":"2017","unstructured":"Matsuura N,\nOkamura T,\nIde S,\nIchinohe T. Remifentanil reduces blood loss during orthognathic surgery. Anesth Prog. 2017;64:3\u20137."},{"key":"i1878-7177-72-2-80-b08","series-title":"J Oral Maxillofac Surg","first-page":"1882.e1\u20131882","article-title":"Propofol versus remifentanil: which one is more effective in reducing blood loss during orthognathic surgery? A randomized clinical trial","volume":"76","author":"Eshghpour M","year":"2018","unstructured":"Eshghpour M,\nSamieirad S,\nSharifian Attar A,\nKermani H,\nSeddigh S. Propofol versus remifentanil: which one is more effective in reducing blood loss during orthognathic surgery? A randomized clinical trial. J Oral Maxillofac Surg. 2018;76:1882.e1\u20131882.e7."},{"key":"i1878-7177-72-2-80-b09","series-title":"]. J Jpn Soc Clin Anesth","first-page":"455","article-title":"Remifentanil anesthesia: efficacy and the prevention of adverse effects [in Japanese","volume":"29","author":"Koitabashi T.","year":"2009","unstructured":"Koitabashi T. Remifentanil anesthesia: efficacy and the prevention of adverse effects [in Japanese]. J Jpn Soc Clin Anesth. 2009;29:455\u2212466."},{"key":"i1878-7177-72-2-80-b10","series-title":"Br J Pharmacol","first-page":"52","article-title":"A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems","volume":"155","author":"Upton RN","year":"2008","unstructured":"Upton RN,\nMartinez AM,\nGrant C. A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems. Br J Pharmacol. 2008;155:52\u201361."},{"key":"i1878-7177-72-2-80-b11","series-title":"Br J Anaesth","first-page":"848","article-title":"Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep","volume":"103","author":"Upton RN","year":"2009","unstructured":"Upton RN,\nMartinez AM,\nGrant C. Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep. Br J Anaesth. 2009;103:848\u2212857."},{"key":"i1878-7177-72-2-80-b12","series-title":"Common Problems in Cardiac Anesthesia","first-page":"356","article-title":"Valium-fentanyl interaction","author":"Reves JG","year":"1987","unstructured":"Reves JG,\nCroughwell N. Valium-fentanyl interaction. In: \nReves JG,\nHall K, eds. Common Problems in Cardiac Anesthesia. Year Book Medical Publishers;1987:356\u2212361."},{"key":"i1878-7177-72-2-80-b13","series-title":"J Oral Maxillofac Surg","first-page":"15","article-title":"Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits","volume":"68","author":"Terakawa Y","year":"2010","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits. J Oral Maxillofac Surg. 2010;68:15\u221220."},{"key":"i1878-7177-72-2-80-b14","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"268","article-title":"Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit","volume":"85","author":"Ichinohe T","year":"1998","unstructured":"Ichinohe T,\nHomma Y,\nKaneko Y. Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:268\u2212271."},{"key":"i1878-7177-72-2-80-b15","series-title":"Anesth Pain Med","first-page":"1","article-title":"Remimazolam: pharmacological characteristics and clinical applications in anesthesiology","volume":"17","author":"Kim KM.","year":"2022","unstructured":"Kim KM. Remimazolam: pharmacological characteristics and clinical applications in anesthesiology. Anesth Pain Med. 2022;17:1\u221211."},{"key":"i1878-7177-72-2-80-b16","series-title":"Effects of Anesthesia","first-page":"179","article-title":"Cardiovascular effects of intravenous anesthetic drugs","author":"Reves J","year":"1985","unstructured":"Reves J,\nGelman S. Cardiovascular effects of intravenous anesthetic drugs. In: \nCovino BG,\nFozzard HA,\nRehder K,\nStrichartz G, eds. Effects of Anesthesia. American Physiological Society;1985:179\u2212193."},{"key":"i1878-7177-72-2-80-b17","series-title":"J Cardiothorac Vasc Anesth","first-page":"763","article-title":"Effects of remifentanil on the contractility of failing human heart muscle","volume":"19","author":"Ogletree ML","year":"2005","unstructured":"Ogletree ML,\nSprung J,\nMoravec CS. Effects of remifentanil on the contractility of failing human heart muscle. J Cardiothorac Vasc Anesth. 2005;19:763\u2212767."},{"key":"i1878-7177-72-2-80-b18","series-title":"Textbook of Intravenous Anesthesia","first-page":"213","article-title":"Fentanyl and congeners","author":"Bailey P","year":"1997","unstructured":"Bailey P,\nEgan T. Fentanyl and congeners. In: \nWhite PF, ed. Textbook of Intravenous Anesthesia. Williams & Wilkins; 1997:213\u2212245."},{"key":"i1878-7177-72-2-80-b19","series-title":"J Vet Med Sci","first-page":"354","article-title":"Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits","volume":"80","author":"Hirata A","year":"2018","unstructured":"Hirata A,\nKasahara M,\nMatsuura N,\nIchinohe T. Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits. J Vet Med Sci. 2018;80:354\u2212360."},{"key":"i1878-7177-72-2-80-b20","series-title":"J Oral Maxillofac Surg","first-page":"965","article-title":"Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits","volume":"77","author":"Kobayashi S","year":"2019","unstructured":"Kobayashi S,\nKasahara M,\nAkiike Y,\nMatsuura N,\nIchinohe T. Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits. J Oral Maxillofac Surg. 2019;77:965\u2212970."},{"key":"i1878-7177-72-2-80-b21","series-title":"Anesthesiology","first-page":"1350","article-title":"Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil","volume":"97","author":"Bouillon T","year":"2002","unstructured":"Bouillon T,\nBruhn J,\nRadu-Radulescu L,\nBertaccini E,\nPark S,\nShafer S. Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. Anesthesiology. 2002;97:1350\u22121362."},{"key":"i1878-7177-72-2-80-b22","series-title":"Curr Med Chem","first-page":"249","article-title":"Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery","volume":"7","author":"Trapani G","year":"2000","unstructured":"Trapani G,\nAltomare C,\nLiso G,\nSanna E,\nBiggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7:249\u2212271."},{"key":"i1878-7177-72-2-80-b23","series-title":"Anesthesiology","first-page":"636","article-title":"Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: Part I. Pharmacokinetics and clinical pharmacodynamics","volume":"132","author":"Sch\u00fcttler J","year":"2020","unstructured":"Sch\u00fcttler J,\nEisenried A,\nLerch M,\nFechner J,\nJeleazcov C,\nIhmsen H. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: Part I. Pharmacokinetics and clinical pharmacodynamics. Anesthesiology. 2020;132:636\u2212651."},{"key":"i1878-7177-72-2-80-b01","series-title":"J Orthop Res","first-page":"1473","article-title":"Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials","volume":"14","author":"Jiang J","year":"2019","unstructured":"Jiang J,\nZhou R,\nLi B,\nXue F. Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials. J Orthop Res. 2019;14:1473\u22121476."},{"key":"i1878-7177-72-2-80-b02","series-title":"J R Coll Surg Edinb","first-page":"261","article-title":"Tooth extraction, bleeding and pain control","volume":"4","author":"Al-Bahlani S","year":"2001","unstructured":"Al-Bahlani S,\nSherriff A,\nCrawford PJM. Tooth extraction, bleeding and pain control. J R Coll Surg Edinb. 2001;4:261\u2212264."},{"key":"i1878-7177-72-2-80-b03","series-title":"Int J Oral Maxillofac Surg","first-page":"687","article-title":"Risks and benefits of deliberate hypotension in anaesthesia: a systematic review","volume":"37","author":"Choi WS","year":"2008","unstructured":"Choi WS,\nSamman N. Risks and benefits of deliberate hypotension in anaesthesia: a systematic review. Int J Oral Maxillofac Surg. 2008;37:687\u2212703."},{"key":"i1878-7177-72-2-80-b04","series-title":"Anesthesiology","first-page":"307","article-title":"Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery","volume":"123","author":"Monk TG","year":"2015","unstructured":"Monk TG,\nBronsert MR,\nHenderson WG, et al. Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery. Anesthesiology. 2015;123:307\u2212319."},{"key":"i1878-7177-72-2-80-b05","series-title":"J Vet Med Sci","first-page":"62","article-title":"Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow","volume":"83","author":"Kobayashi A","year":"2021","unstructured":"Kobayashi A,\nKasaghara M,\nAkiike Y,\nKoshika K,\nIchinohe T. Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow. J Vet Med Sci. 2021;83:62\u201368."},{"key":"i1878-7177-72-2-80-b06","series-title":"J Oral Maxillofac Surg","first-page":"2128","article-title":"Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits","volume":"69","author":"Koshika K","year":"2011","unstructured":"Koshika K,\nIchinohe T,\nKaneko Y. Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits. J Oral Maxillofac Surg. 2011;69:2128\u22122134."},{"key":"i1878-7177-72-2-80-b07","series-title":"Anesth Prog","first-page":"3","article-title":"Remifentanil reduces blood loss during orthognathic surgery","volume":"64","author":"Matsuura N","year":"2017","unstructured":"Matsuura N,\nOkamura T,\nIde S,\nIchinohe T. Remifentanil reduces blood loss during orthognathic surgery. Anesth Prog. 2017;64:3\u20137."},{"key":"i1878-7177-72-2-80-b08","series-title":"J Oral Maxillofac Surg","first-page":"1882.e1\u20131882","article-title":"Propofol versus remifentanil: which one is more effective in reducing blood loss during orthognathic surgery? A randomized clinical trial","volume":"76","author":"Eshghpour M","year":"2018","unstructured":"Eshghpour M,\nSamieirad S,\nSharifian Attar A,\nKermani H,\nSeddigh S. Propofol versus remifentanil: which one is more effective in reducing blood loss during orthognathic surgery? A randomized clinical trial. J Oral Maxillofac Surg. 2018;76:1882.e1\u20131882.e7."},{"key":"i1878-7177-72-2-80-b09","series-title":"]. J Jpn Soc Clin Anesth","first-page":"455","article-title":"Remifentanil anesthesia: efficacy and the prevention of adverse effects [in Japanese","volume":"29","author":"Koitabashi T.","year":"2009","unstructured":"Koitabashi T. Remifentanil anesthesia: efficacy and the prevention of adverse effects [in Japanese]. J Jpn Soc Clin Anesth. 2009;29:455\u2212466."},{"key":"i1878-7177-72-2-80-b10","series-title":"Br J Pharmacol","first-page":"52","article-title":"A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems","volume":"155","author":"Upton RN","year":"2008","unstructured":"Upton RN,\nMartinez AM,\nGrant C. A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems. Br J Pharmacol. 2008;155:52\u201361."},{"key":"i1878-7177-72-2-80-b11","series-title":"Br J Anaesth","first-page":"848","article-title":"Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep","volume":"103","author":"Upton RN","year":"2009","unstructured":"Upton RN,\nMartinez AM,\nGrant C. Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep. Br J Anaesth. 2009;103:848\u2212857."},{"key":"i1878-7177-72-2-80-b12","series-title":"Common Problems in Cardiac Anesthesia","first-page":"356","article-title":"Valium-fentanyl interaction","author":"Reves JG","year":"1987","unstructured":"Reves JG,\nCroughwell N. Valium-fentanyl interaction. In: \nReves JG,\nHall K, eds. Common Problems in Cardiac Anesthesia. Year Book Medical Publishers;1987:356\u2212361."},{"key":"i1878-7177-72-2-80-b13","series-title":"J Oral Maxillofac Surg","first-page":"15","article-title":"Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits","volume":"68","author":"Terakawa Y","year":"2010","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits. J Oral Maxillofac Surg. 2010;68:15\u221220."},{"key":"i1878-7177-72-2-80-b14","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"268","article-title":"Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit","volume":"85","author":"Ichinohe T","year":"1998","unstructured":"Ichinohe T,\nHomma Y,\nKaneko Y. Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:268\u2212271."},{"key":"i1878-7177-72-2-80-b15","series-title":"Anesth Pain Med","first-page":"1","article-title":"Remimazolam: pharmacological characteristics and clinical applications in anesthesiology","volume":"17","author":"Kim KM.","year":"2022","unstructured":"Kim KM. Remimazolam: pharmacological characteristics and clinical applications in anesthesiology. Anesth Pain Med. 2022;17:1\u221211."},{"key":"i1878-7177-72-2-80-b16","series-title":"Effects of Anesthesia","first-page":"179","article-title":"Cardiovascular effects of intravenous anesthetic drugs","author":"Reves J","year":"1985","unstructured":"Reves J,\nGelman S. Cardiovascular effects of intravenous anesthetic drugs. In: \nCovino BG,\nFozzard HA,\nRehder K,\nStrichartz G, eds. Effects of Anesthesia. American Physiological Society;1985:179\u2212193."},{"key":"i1878-7177-72-2-80-b17","series-title":"J Cardiothorac Vasc Anesth","first-page":"763","article-title":"Effects of remifentanil on the contractility of failing human heart muscle","volume":"19","author":"Ogletree ML","year":"2005","unstructured":"Ogletree ML,\nSprung J,\nMoravec CS. Effects of remifentanil on the contractility of failing human heart muscle. J Cardiothorac Vasc Anesth. 2005;19:763\u2212767."},{"key":"i1878-7177-72-2-80-b18","series-title":"Textbook of Intravenous Anesthesia","first-page":"213","article-title":"Fentanyl and congeners","author":"Bailey P","year":"1997","unstructured":"Bailey P,\nEgan T. Fentanyl and congeners. In: \nWhite PF, ed. Textbook of Intravenous Anesthesia. Williams & Wilkins; 1997:213\u2212245."},{"key":"i1878-7177-72-2-80-b19","series-title":"J Vet Med Sci","first-page":"354","article-title":"Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits","volume":"80","author":"Hirata A","year":"2018","unstructured":"Hirata A,\nKasahara M,\nMatsuura N,\nIchinohe T. Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits. J Vet Med Sci. 2018;80:354\u2212360."},{"key":"i1878-7177-72-2-80-b20","series-title":"J Oral Maxillofac Surg","first-page":"965","article-title":"Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits","volume":"77","author":"Kobayashi S","year":"2019","unstructured":"Kobayashi S,\nKasahara M,\nAkiike Y,\nMatsuura N,\nIchinohe T. Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits. J Oral Maxillofac Surg. 2019;77:965\u2212970."},{"key":"i1878-7177-72-2-80-b21","series-title":"Anesthesiology","first-page":"1350","article-title":"Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil","volume":"97","author":"Bouillon T","year":"2002","unstructured":"Bouillon T,\nBruhn J,\nRadu-Radulescu L,\nBertaccini E,\nPark S,\nShafer S. Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. Anesthesiology. 2002;97:1350\u22121362."},{"key":"i1878-7177-72-2-80-b22","series-title":"Curr Med Chem","first-page":"249","article-title":"Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery","volume":"7","author":"Trapani G","year":"2000","unstructured":"Trapani G,\nAltomare C,\nLiso G,\nSanna E,\nBiggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7:249\u2212271."},{"key":"i1878-7177-72-2-80-b23","series-title":"Anesthesiology","first-page":"636","article-title":"Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: Part I. Pharmacokinetics and clinical pharmacodynamics","volume":"132","author":"Sch\u00fcttler J","year":"2020","unstructured":"Sch\u00fcttler J,\nEisenried A,\nLerch M,\nFechner J,\nJeleazcov C,\nIhmsen H. Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: Part I. Pharmacokinetics and clinical pharmacodynamics. Anesthesiology. 2020;132:636\u2212651."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/2\/article-p80.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/2\/article-p80.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/2\/article-p80.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T02:20:07Z","timestamp":1779848407000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/2\/article-p80.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":46,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2344\/23-0045","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}