{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T01:10:08Z","timestamp":1742865008263,"version":"3.40.2"},"reference-count":7,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>We successfully anesthetized a 15-year-old male dental patient with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome using remimazolam and remifentanil. During the rapid sequence induction, we administered intravenous continuous infusions of remimazolam and remfentanil along with boluses of fentanyl and rocuronium to quickly induce general anesthesia without complications. General anesthesia was maintained during the operation with continuous infusions of remimazolam (0.8\u20131.0 mg\/kg\/h) and remifentanil (0.15\u20130.2 \u03bcg\/kg\/min) while using a SedLine monitor to help assess anesthetic depth. Except for immediately after extubation, the patient was stable postoperatively. He progressed satisfactorily and was discharged safely the following day. This experience suggests that the combination of remimazolam and remifentanil is an effective anesthetic for adolescent patients with MELAS syndrome undergoing dental procedures requiring general anesthesia.<\/jats:p>","DOI":"10.2344\/23-0051","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:02:28Z","timestamp":1742860948000},"page":"46-48","source":"Crossref","is-referenced-by-count":0,"title":["Anesthetic Management With Remimazolam for Adolescent Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes (MELAS): A Case Report"],"prefix":"10.2344","volume":"72","author":[{"given":"Mie","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka Dental University, Osaka, Japan"},{"name":"Department of Anesthesiology, Nara Medical University, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nara Medical University, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Momota","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka Dental University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nara Medical University, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i1878-7177-72-1-46-b01","series-title":"Korean J Anesthesiol","first-page":"409","article-title":"Total intravenous anesthesia with propofol and remifentanil in a patient with MELAS syndrome -a case report","volume":"58","author":"Park JS,","year":"2010","unstructured":"Park JS,\nBaek CW,\nKang H,\nCha SM,\nPark JW,\nJung YH,\nWoo YC. Total intravenous anesthesia with propofol and remifentanil in a patient with MELAS syndrome -a case report. Korean J Anesthesiol. 2010;58:409\u2013412."},{"key":"i1878-7177-72-1-46-b02","series-title":"J Jpn Dent Soc Anesthesiol","first-page":"31","article-title":"Day-care anesthesia for dental treatment in a patient with mitochondrial encephalomyopathy combined with hyperCKemia [in Japanese]","volume":"46","author":"Saito A,","year":"2018","unstructured":"Saito A,\nKukidome H,\nKobayashi A,\nInoue H,\nMatsuura N,\nIchinohe T. Day-care anesthesia for dental treatment in a patient with mitochondrial encephalomyopathy combined with hyperCKemia [in Japanese]. J Jpn Dent Soc Anesthesiol. 2018;46:31\u201333."},{"key":"i1878-7177-72-1-46-b03","series-title":"Anaesthesia","first-page":"690","article-title":"Propofol infusion syndrome","volume":"62","author":"Kam PCA,","year":"2007","unstructured":"Kam PCA,\nCardone D. Propofol infusion syndrome. Anaesthesia. 2007;62:690\u2013701."},{"key":"i1878-7177-72-1-46-b04","series-title":"J Jpn Dent Soc Anesthesiol","first-page":"80","article-title":"Intravenous sedation in a patient with Leigh encephalomyelopathy undergoing dental treatment [in Japanese]","volume":"46","author":"Sago T,","year":"2018","unstructured":"Sago T,\nAndo E,\nTsunakake M,\nOno A,\nAkitomi S,\nNagahata S,\nNakashima T,\nShiiba S,\nWatanabe S. Intravenous sedation in a patient with Leigh encephalomyelopathy undergoing dental treatment [in Japanese]. J Jpn Dent Soc Anesthesiol. 2018;46:80\u201382."},{"key":"i1878-7177-72-1-46-b05","series-title":"JA Clin Rep","first-page":"51","article-title":"General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report","volume":"7","author":"Suzuki Y,","year":"2021","unstructured":"Suzuki Y,\nDoi M,\nNakajima Y. General anesthesia with remimazolam in a patient with mitochondrial encephalomyopathy: a case report. JA Clin Rep. 2021;7:51."},{"key":"i1878-7177-72-1-46-b06","series-title":"Eur J Clin Pharmacy","first-page":"271","article-title":"The pharmacokinetics of midazolam in man","volume":"19","author":"Smith MT,","year":"1981","unstructured":"Smith MT,\nEddie MJ,\nBrophy TO. The pharmacokinetics of midazolam in man. Eur J Clin Pharmacy.1981;19:271\u2013278."},{"key":"i1878-7177-72-1-46-b07","series-title":"Clin Pharmacol Ther","first-page":"106","article-title":"Intravenous fentanyl kinetics","volume":"28","author":"McClain DA,","year":"1980","unstructured":"McClain DA,\nHug CC Jr. Intravenous fentanyl kinetics. Clin Pharmacol Ther.1980;28:106\u2013114."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/1\/article-p46.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/1\/article-p46.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/72\/1\/article-p46.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:06:24Z","timestamp":1742861184000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/72\/1\/article-p46.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":7,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2344\/23-0051","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}