{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:02:45Z","timestamp":1779850965010,"version":"3.53.1"},"reference-count":70,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of remifentanil infusion under inhaled anesthesia on changes in oral tissue blood flow and tissue oxygen tension during noxious stimulation of the oral region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen male Japan White rabbits were used. General anesthesia was maintained with sevoflurane or desflurane. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP), heart rate (HR), mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue oxygen tension (PbO\n                      <jats:sub>2<\/jats:sub>\n                      ), and masseter muscle tissue oxygen tension (PmO\n                      <jats:sub>2<\/jats:sub>\n                      ) were measured before and after electrical stimulation, with and without remifentanil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Remifentanil decreased the rate of change in SBP, DBP, MAP, BBF, and MBF, whereas PbO\n                      <jats:sub>2<\/jats:sub>\n                      and PmO\n                      <jats:sub>2<\/jats:sub>\n                      remained unchanged.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Remifentanil suppressed hemodynamics and oral tissue blood flow changes after electrical stimulation and maintained oral tissue oxygen tension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2344\/24-0033","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:26:24Z","timestamp":1772810784000},"page":"14-21","source":"Crossref","is-referenced-by-count":0,"title":["Remifentanil Diminishes Stimulation-Induced Oral Tissue Blood Flow Changes"],"prefix":"10.2344","volume":"73","author":[{"given":"Yasuhiro","family":"Jinbo","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyotaro","family":"Koshika","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Akiike","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i1878-7177-73-1-14-b01","series-title":"J Dent Res Rev","first-page":"79","article-title":"Bleeding control measures during oral and maxillofacial surgical procedures: a systematic review","volume":"4","author":"Akolkar AR","year":"2017","unstructured":"Akolkar AR,\nKulkarni DG,\nGangwani KD,\nShetty L,\nChanne SP,\nSarve PH. Bleeding control measures during oral and maxillofacial surgical procedures: a systematic review. J Dent Res Rev. 2017;4:79\u201389."},{"key":"i1878-7177-73-1-14-b02","series-title":"Front Pharmacol","first-page":"58","article-title":"Post-operative bleeding risk in dental surgery for patients on oral anticoagulant therapy: a meta-analysis of observational studies","volume":"8","author":"Shi Q","year":"2017","unstructured":"Shi Q,\nXu J,\nZhang T,\nZhamg B,\nLiu H. Post-operative bleeding risk in dental surgery for patients on oral anticoagulant therapy: a meta-analysis of observational studies. Front Pharmacol. 2017;8:58."},{"key":"i1878-7177-73-1-14-b03","series-title":"Aesthet Surg J","first-page":"587","article-title":"Local infiltration of tranexamic acid with local anesthetic reduces intraoperative facelift bleeding: a preliminary report","volume":"40","author":"Couto RA","year":"2020","unstructured":"Couto RA,\nCharafeddine A,\nSinclair NR,\nNayak LM,\nZins JE. Local infiltration of tranexamic acid with local anesthetic reduces intraoperative facelift bleeding: a preliminary report. Aesthet Surg J. 2020;40:587\u2013593."},{"key":"i1878-7177-73-1-14-b04","series-title":"J Orthop Surg Res","first-page":"1473","article-title":"Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials","volume":"14","author":"Jiang J","year":"2019","unstructured":"Jiang J,\nZhou R,\nLi B,\nXue F. Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials. J Orthop Surg Res. 2019;14:1473\u20131476."},{"key":"i1878-7177-73-1-14-b05","series-title":"J R Coll Surg Edinb","first-page":"261","article-title":"Tooth extraction, bleeding and pain control","volume":"4","author":"Al-Bahlani S","year":"2001","unstructured":"Al-Bahlani S,\nSherriff A,\nCrawford PJM. Tooth extraction, bleeding and pain control. J R Coll Surg Edinb. 2001;4:261\u2013264."},{"key":"i1878-7177-73-1-14-b06","series-title":"Int J Oral Maxillofac Surg","first-page":"687","article-title":"Risks and benefits of deliberate hypotension in anaesthesia: a systematic review","volume":"37","author":"Choi WS","year":"2008","unstructured":"Choi WS,\nSamman N. Risks and benefits of deliberate hypotension in anaesthesia: a systematic review. Int J Oral Maxillofac Surg. 2008;37:687\u2013703."},{"key":"i1878-7177-73-1-14-b07","series-title":"J Dent Anesth Pain Med","first-page":"319","article-title":"Efficacy of dental local anesthetics: a review","volume":"18","author":"Badr N","year":"2018","unstructured":"Badr N,\nAps J. Efficacy of dental local anesthetics: a review. J Dent Anesth Pain Med. 2018;18:319\u2013332."},{"key":"i1878-7177-73-1-14-b08","series-title":"Anesthesiology","first-page":"307","article-title":"Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery","volume":"123","author":"Monk TG","year":"2015","unstructured":"Monk TG,\nBronsert MR,\nHenderson WG, et al. Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery. Anesthesiology. 2015;123:307\u2013319."},{"key":"i1878-7177-73-1-14-b09","series-title":"J Oral Maxillofac Surg","first-page":"1245","article-title":"Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits","volume":"67","author":"Kemmochi M","year":"2009","unstructured":"Kemmochi M,\nIchinohe T,\nKaneko Y. Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits. J Oral Maxillofac Surg. 2009;67:1245\u20131250."},{"key":"i1878-7177-73-1-14-b10","series-title":"J Oral Maxillofac Surg","first-page":"2128","article-title":"Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits","volume":"69","author":"Koshika K","year":"2011","unstructured":"Koshika K,\nIchinohe T,\nKaneko Y. Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits. J Oral Maxillofac Surg. 2011;69:2128\u20132134."},{"key":"i1878-7177-73-1-14-b11","series-title":"Bull Tokyo Dent Coll","first-page":"83","article-title":"Relationship between oral tissue blood flow and oxygen tension in rabbit","volume":"50","author":"Terakawa Y","year":"2009","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. Relationship between oral tissue blood flow and oxygen tension in rabbit. Bull Tokyo Dent Coll. 2009;50:83\u201390."},{"key":"i1878-7177-73-1-14-b12","series-title":"Br J Dermatol","first-page":"257","article-title":"Oxygen in acute and chronic wound healing","volume":"163","author":"Schreml S","year":"2010","unstructured":"Schreml S,\nSzeimies RM,\nPrantl L,\nKarrer S,\nLandthaler M,\nBabilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163:257\u2013268."},{"key":"i1878-7177-73-1-14-b13","series-title":"J Oral Maxillofac Surg","first-page":"965","article-title":"Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits","volume":"77","author":"Kobayashi S","year":"2019","unstructured":"Kobayashi S,\nKasahara M,\nAkiike Y,\nMatsuura N,\nIchinohe T. Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits. J Oral Maxillofac Surg. 2019;77:965\u2013970."},{"key":"i1878-7177-73-1-14-b14","series-title":"J Vet Med Sci","first-page":"62","article-title":"Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow","volume":"83","author":"Kobayashi A","year":"2021","unstructured":"Kobayashi A,\nKasahara M,\nKoshika K,\nAkiike Y,\nMatsuura N,\nIchinohe T. Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow. J Vet Med Sci. 2021;83:62\u201368."},{"key":"i1878-7177-73-1-14-b15","series-title":"Mol Pain","first-page":"1","article-title":"Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis","volume":"16","author":"Inada Y","year":"2020","unstructured":"Inada Y,\nFunai Y,\nYamasaki H,\nMori T,\nNishikawa K. Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis. Mol Pain. 2020;16:1\u201314."},{"key":"i1878-7177-73-1-14-b16","series-title":"J Oral Maxillofac Surg","first-page":"15","article-title":"Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits","volume":"68","author":"Terakawa Y","year":"2010","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits. J Oral Maxillofac Surg. 2010;68:15\u201320."},{"key":"i1878-7177-73-1-14-b17","series-title":"Phys Med Biol","first-page":"1413","article-title":"Local hydrogen clearance as a method for the measurement of capillary blood flow","volume":"34","author":"Harrison DK","year":"1989","unstructured":"Harrison DK,\nKessler M. Local hydrogen clearance as a method for the measurement of capillary blood flow. Phys Med Biol.1989;34:1413\u20131428."},{"key":"i1878-7177-73-1-14-b18","series-title":"Int J Radiat Oncol Biol Phys","first-page":"111","volume":"33","author":"Yeh KA","year":"1995","unstructured":"Yeh KA,\nBiade S,\nLanciano RM, et al. Int J Radiat Oncol Biol Phys. 1995;33:111\u2013118."},{"key":"i1878-7177-73-1-14-b19","series-title":"J Japanese Dent Soc Anesthesiol","first-page":"286","article-title":"Inhibitory effects of various antimaximum agents on the hemodynamic responses to noxious stimulations in the oral region (in Japanese)","volume":"27","author":"Ichinohe T.","year":"1999","unstructured":"Ichinohe T. Inhibitory effects of various antimaximum agents on the hemodynamic responses to noxious stimulations in the oral region (in Japanese). J Japanese Dent Soc Anesthesiol. 1999;27:286\u2013292."},{"key":"i1878-7177-73-1-14-b20","series-title":"Can J Anaesth","first-page":"153","article-title":"MAC of sevoflurane in humans and the New Zealand white rabbit","volume":"35","author":"Scheller MS","year":"1988","unstructured":"Scheller MS,\nSaidman LJ,\nPartridge BL. MAC of sevoflurane in humans and the New Zealand white rabbit. 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Kagaku To Seibutsu (Chemistry and Biology). 2019;57:629\u2013647."},{"key":"i1878-7177-73-1-14-b23","series-title":"Physiol Rev","first-page":"916","article-title":"Somatosympathetic reflexes: afferent fibers, central pathways, discharge characteristics","volume":"53","author":"Sato A","year":"1973","unstructured":"Sato A,\nSchmidt RF. Somatosympathetic reflexes: afferent fibers, central pathways, discharge characteristics. Physiol Rev. 1973;53:916\u2013947."},{"key":"i1878-7177-73-1-14-b24","series-title":"Neuroscience","first-page":"133","article-title":"Activation of mu-opioid receptors in rat ventrolateral medulla selectively blocks baroreceptor reflexes while activation of delta opioid receptors blocks somato-sympathetic reflexes","volume":"109","author":"Miyawaki T","year":"2002","unstructured":"Miyawaki T,\nGoodchild AK,\nPilowsky PM. Activation of mu-opioid receptors in rat ventrolateral medulla selectively blocks baroreceptor reflexes while activation of delta opioid receptors blocks somato-sympathetic reflexes. Neuroscience. 2002;109:133\u2013144."},{"key":"i1878-7177-73-1-14-b25","series-title":"Br J Anaesth","first-page":"575","article-title":"High- and low-dose fentanyl anaesthesia: hormonal and metabolic responses during cholecystectomy","volume":"61","author":"Giesecke K","year":"1988","unstructured":"Giesecke K,\nHamberger B,\nJ\u00e4rnberg PO,\nKlingstedt C,\nPersson B. High- and low-dose fentanyl anaesthesia: hormonal and metabolic responses during cholecystectomy. Br J Anaesth. 1988;61:575\u2013582."},{"key":"i1878-7177-73-1-14-b26","series-title":"Anesth Analg","first-page":"453","article-title":"The combined effects of sevoflurane and remifentanil on central respiratory activity and nociceptive cardiovascular responses in anesthetized rabbits","volume":"89","author":"Ma D","year":"1999","unstructured":"Ma D,\nChakrabarti MK,\nWhitwam JG. The combined effects of sevoflurane and remifentanil on central respiratory activity and nociceptive cardiovascular responses in anesthetized rabbits. Anesth Analg.1999;89:453\u2013461."},{"key":"i1878-7177-73-1-14-b27","series-title":"Minerva Anestesiol","first-page":"7","article-title":"Desflurane versus sevoflurane: a comparison on stress response","volume":"79","author":"Marana E","year":"2013","unstructured":"Marana E,\nRusso A,\nColicci S, et al. Desflurane versus sevoflurane: a comparison on stress response. Minerva Anestesiol. 2013;79:7\u201314."},{"key":"i1878-7177-73-1-14-b28","series-title":"Anesth Prog","first-page":"118","article-title":"Large-dose epinephrine reduces skeletal muscle blood flow under general anesthesia in rabbits","volume":"59","author":"Terakawa Y","year":"2012","unstructured":"Terakawa Y,\nIchinohe T. Large-dose epinephrine reduces skeletal muscle blood flow under general anesthesia in rabbits. Anesth Prog. 2012;59:118\u2013122."},{"key":"i1878-7177-73-1-14-b29","series-title":"Anesth Analg","first-page":"55","article-title":"Desflurane attenuates the somatosympathetic reflex in rats","volume":"83","author":"Ganjoo P","year":"1996","unstructured":"Ganjoo P,\nFarber NE,\nSchwabe D,\nKampine JP,\nSchmeling WT. Desflurane attenuates the somatosympathetic reflex in rats. Anesth Analg. 1996;83:55\u201361."},{"key":"i1878-7177-73-1-14-b30","series-title":"Arch Oral Biol","first-page":"295","article-title":"Trigeminal nerve inputs and central blood pressure change in the cat","volume":"14","author":"Dellow PG","year":"1969","unstructured":"Dellow PG,\nMorgan MJ. Trigeminal nerve inputs and central blood pressure change in the cat. Arch Oral Biol. 1969;14:295\u2013300."},{"key":"i1878-7177-73-1-14-b31","series-title":"J Auton Nerv Syst","first-page":"111","article-title":"Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits","volume":"66","author":"Ichinohe T","year":"1997","unstructured":"Ichinohe T,\nAgata H,\nAida H,\nKaneko Y. Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits. J Auton Nerv Syst. 1997;66:111\u2013118."},{"key":"i1878-7177-73-1-14-b32","series-title":"Brain Res","first-page":"305","article-title":"The trigeminal depressor response: a novel vasodepressor response originating from the trigeminal system","volume":"119","author":"Kumada M","year":"1977","unstructured":"Kumada M,\nDampney RAL,\nReis DJ. The trigeminal depressor response: a novel vasodepressor response originating from the trigeminal system. Brain Res. 1977;119:305\u2013326."},{"key":"i1878-7177-73-1-14-b33","series-title":"Anesth Analg","first-page":"971","article-title":"The effects of halothane on pressor and depressor responses elicited via the somatosympathetic reflex: a potential antinociceptive action","volume":"79","author":"Samso E","year":"1994","unstructured":"Samso E,\nFarber NE,\nKampine JP,\nSchmeling WT. The effects of halothane on pressor and depressor responses elicited via the somatosympathetic reflex: a potential antinociceptive action. Anesth Analg. 1994;79:971\u2013979."},{"key":"i1878-7177-73-1-14-b34","series-title":"Anesthesiology","first-page":"783","article-title":"Minimum alveolar concentrations (MAC) of halothane, enflurane, and isoflurane in ferrets","volume":"68","author":"Murat I","year":"1988","unstructured":"Murat I,\nHousmans PR. Minimum alveolar concentrations (MAC) of halothane, enflurane, and isoflurane in ferrets. Anesthesiology. 1988;68:783\u2013786."},{"key":"i1878-7177-73-1-14-b35","series-title":"Anaesthesist","first-page":"421","article-title":"Perioperative inflammation","volume":"68","author":"Rossaint J","year":"2019","unstructured":"Rossaint J,\nMargraf A,\nZarbock A. Perioperative inflammation. Anaesthesist. 2019;68:421\u2013427."},{"key":"i1878-7177-73-1-14-b01","series-title":"J Dent Res Rev","first-page":"79","article-title":"Bleeding control measures during oral and maxillofacial surgical procedures: a systematic review","volume":"4","author":"Akolkar AR","year":"2017","unstructured":"Akolkar AR,\nKulkarni DG,\nGangwani KD,\nShetty L,\nChanne SP,\nSarve PH. Bleeding control measures during oral and maxillofacial surgical procedures: a systematic review. J Dent Res Rev. 2017;4:79\u201389."},{"key":"i1878-7177-73-1-14-b02","series-title":"Front Pharmacol","first-page":"58","article-title":"Post-operative bleeding risk in dental surgery for patients on oral anticoagulant therapy: a meta-analysis of observational studies","volume":"8","author":"Shi Q","year":"2017","unstructured":"Shi Q,\nXu J,\nZhang T,\nZhamg B,\nLiu H. Post-operative bleeding risk in dental surgery for patients on oral anticoagulant therapy: a meta-analysis of observational studies. Front Pharmacol. 2017;8:58."},{"key":"i1878-7177-73-1-14-b03","series-title":"Aesthet Surg J","first-page":"587","article-title":"Local infiltration of tranexamic acid with local anesthetic reduces intraoperative facelift bleeding: a preliminary report","volume":"40","author":"Couto RA","year":"2020","unstructured":"Couto RA,\nCharafeddine A,\nSinclair NR,\nNayak LM,\nZins JE. Local infiltration of tranexamic acid with local anesthetic reduces intraoperative facelift bleeding: a preliminary report. Aesthet Surg J. 2020;40:587\u2013593."},{"key":"i1878-7177-73-1-14-b04","series-title":"J Orthop Surg Res","first-page":"1473","article-title":"Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials","volume":"14","author":"Jiang J","year":"2019","unstructured":"Jiang J,\nZhou R,\nLi B,\nXue F. Is deliberate hypotension a safe technique for orthopedic surgery? A systematic review and meta-analysis of parallel randomized controlled trials. J Orthop Surg Res. 2019;14:1473\u20131476."},{"key":"i1878-7177-73-1-14-b05","series-title":"J R Coll Surg Edinb","first-page":"261","article-title":"Tooth extraction, bleeding and pain control","volume":"4","author":"Al-Bahlani S","year":"2001","unstructured":"Al-Bahlani S,\nSherriff A,\nCrawford PJM. Tooth extraction, bleeding and pain control. J R Coll Surg Edinb. 2001;4:261\u2013264."},{"key":"i1878-7177-73-1-14-b06","series-title":"Int J Oral Maxillofac Surg","first-page":"687","article-title":"Risks and benefits of deliberate hypotension in anaesthesia: a systematic review","volume":"37","author":"Choi WS","year":"2008","unstructured":"Choi WS,\nSamman N. Risks and benefits of deliberate hypotension in anaesthesia: a systematic review. Int J Oral Maxillofac Surg. 2008;37:687\u2013703."},{"key":"i1878-7177-73-1-14-b07","series-title":"J Dent Anesth Pain Med","first-page":"319","article-title":"Efficacy of dental local anesthetics: a review","volume":"18","author":"Badr N","year":"2018","unstructured":"Badr N,\nAps J. Efficacy of dental local anesthetics: a review. J Dent Anesth Pain Med. 2018;18:319\u2013332."},{"key":"i1878-7177-73-1-14-b08","series-title":"Anesthesiology","first-page":"307","article-title":"Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery","volume":"123","author":"Monk TG","year":"2015","unstructured":"Monk TG,\nBronsert MR,\nHenderson WG, et al. Association between intraoperative hypotension and hypertension and 30-day postoperative mortality in noncardiac surgery. Anesthesiology. 2015;123:307\u2013319."},{"key":"i1878-7177-73-1-14-b09","series-title":"J Oral Maxillofac Surg","first-page":"1245","article-title":"Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits","volume":"67","author":"Kemmochi M","year":"2009","unstructured":"Kemmochi M,\nIchinohe T,\nKaneko Y. Remifentanil decreases mandibular bone marrow blood flow during propofol or sevoflurane anesthesia in rabbits. J Oral Maxillofac Surg. 2009;67:1245\u20131250."},{"key":"i1878-7177-73-1-14-b10","series-title":"J Oral Maxillofac Surg","first-page":"2128","article-title":"Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits","volume":"69","author":"Koshika K","year":"2011","unstructured":"Koshika K,\nIchinohe T,\nKaneko Y. Dose-dependent remifentanil decreases oral tissue blood flow during sevoflurane and propofol anesthesia in rabbits. J Oral Maxillofac Surg. 2011;69:2128\u20132134."},{"key":"i1878-7177-73-1-14-b11","series-title":"Bull Tokyo Dent Coll","first-page":"83","article-title":"Relationship between oral tissue blood flow and oxygen tension in rabbit","volume":"50","author":"Terakawa Y","year":"2009","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. Relationship between oral tissue blood flow and oxygen tension in rabbit. Bull Tokyo Dent Coll. 2009;50:83\u201390."},{"key":"i1878-7177-73-1-14-b12","series-title":"Br J Dermatol","first-page":"257","article-title":"Oxygen in acute and chronic wound healing","volume":"163","author":"Schreml S","year":"2010","unstructured":"Schreml S,\nSzeimies RM,\nPrantl L,\nKarrer S,\nLandthaler M,\nBabilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163:257\u2013268."},{"key":"i1878-7177-73-1-14-b13","series-title":"J Oral Maxillofac Surg","first-page":"965","article-title":"Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits","volume":"77","author":"Kobayashi S","year":"2019","unstructured":"Kobayashi S,\nKasahara M,\nAkiike Y,\nMatsuura N,\nIchinohe T. Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits. J Oral Maxillofac Surg. 2019;77:965\u2013970."},{"key":"i1878-7177-73-1-14-b14","series-title":"J Vet Med Sci","first-page":"62","article-title":"Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow","volume":"83","author":"Kobayashi A","year":"2021","unstructured":"Kobayashi A,\nKasahara M,\nKoshika K,\nAkiike Y,\nMatsuura N,\nIchinohe T. Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow. J Vet Med Sci. 2021;83:62\u201368."},{"key":"i1878-7177-73-1-14-b15","series-title":"Mol Pain","first-page":"1","article-title":"Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis","volume":"16","author":"Inada Y","year":"2020","unstructured":"Inada Y,\nFunai Y,\nYamasaki H,\nMori T,\nNishikawa K. Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis. Mol Pain. 2020;16:1\u201314."},{"key":"i1878-7177-73-1-14-b16","series-title":"J Oral Maxillofac Surg","first-page":"15","article-title":"Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits","volume":"68","author":"Terakawa Y","year":"2010","unstructured":"Terakawa Y,\nIchinohe T,\nKaneko Y. 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Anesth Analg. 1996;83:55\u201361."},{"key":"i1878-7177-73-1-14-b30","series-title":"Arch Oral Biol","first-page":"295","article-title":"Trigeminal nerve inputs and central blood pressure change in the cat","volume":"14","author":"Dellow PG","year":"1969","unstructured":"Dellow PG,\nMorgan MJ. Trigeminal nerve inputs and central blood pressure change in the cat. Arch Oral Biol. 1969;14:295\u2013300."},{"key":"i1878-7177-73-1-14-b31","series-title":"J Auton Nerv Syst","first-page":"111","article-title":"Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits","volume":"66","author":"Ichinohe T","year":"1997","unstructured":"Ichinohe T,\nAgata H,\nAida H,\nKaneko Y. Cerebral cortex regional blood flow and tissue oxygen tension during the trigeminal depressor response in rabbits. J Auton Nerv Syst. 1997;66:111\u2013118."},{"key":"i1878-7177-73-1-14-b32","series-title":"Brain Res","first-page":"305","article-title":"The trigeminal depressor response: a novel vasodepressor response originating from the trigeminal system","volume":"119","author":"Kumada M","year":"1977","unstructured":"Kumada M,\nDampney RAL,\nReis DJ. The trigeminal depressor response: a novel vasodepressor response originating from the trigeminal system. Brain Res. 1977;119:305\u2013326."},{"key":"i1878-7177-73-1-14-b33","series-title":"Anesth Analg","first-page":"971","article-title":"The effects of halothane on pressor and depressor responses elicited via the somatosympathetic reflex: a potential antinociceptive action","volume":"79","author":"Samso E","year":"1994","unstructured":"Samso E,\nFarber NE,\nKampine JP,\nSchmeling WT. The effects of halothane on pressor and depressor responses elicited via the somatosympathetic reflex: a potential antinociceptive action. 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