{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:02:33Z","timestamp":1779850953486,"version":"3.53.1"},"reference-count":12,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Dravet syndrome (DS) is a rare, severe form of epilepsy characterized by seizures often triggered by fevers and other nonfebrile increases in body temperature. We report the case of a girl aged 3 years 5 months who underwent an intubated general anesthetic for dental treatment using remimazolam (RMZ). After a slow mask induction with sevoflurane, RMZ, remifentanil, and rocuronium were administered to facilitate oral intubation, after which general anesthesia was maintained with air, oxygen, and continuous infusions of RMZ and remifentanil. Intraoperative temperature and other vital signs were stable, and no fever or convulsions were observed during the perioperative period. RMZ is an ultrashort-acting benzodiazepine that may be useful for the anesthetic management of pediatric patients with DS because of its potential to prevent seizures.<\/jats:p>","DOI":"10.2344\/24-0045","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:10:10Z","timestamp":1765365010000},"page":"246-248","source":"Crossref","is-referenced-by-count":0,"title":["Anesthetic Management Using Remimazolam for Dental Treatment in a Pediatric Patient With Dravet Syndrome"],"prefix":"10.2344","volume":"72","author":[{"given":"Musashi","family":"Sawada","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i1878-7177-72-4-246-b01","series-title":"Pediatr Neurol","first-page":"18","article-title":"Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American consensus panel","volume":"68","author":"Wirrell EC,","year":"2017","unstructured":"Wirrell EC,\nLaux L,\nDonner E, et al. Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American consensus panel. Pediatr Neurol. 2017;68:18\u201334."},{"issue":"5","key":"i1878-7177-72-4-246-b02","series-title":"Brain Dev","first-page":"319","article-title":"The effectiveness of intravenous benzodiazepine for status epilepticus in Dravet syndrome","volume":"44","author":"Kikuchi K,","year":"2022","unstructured":"Kikuchi K,\nHamano S,\nMatsuura R, et al. The effectiveness of intravenous benzodiazepine for status epilepticus in Dravet syndrome. Brain Dev. 2022;44(5):319\u2013328."},{"issue":"5","key":"i1878-7177-72-4-246-b03","series-title":"Br J Anaesth","first-page":"914","article-title":"Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children","volume":"131","author":"Gao YQ,","year":"2023","unstructured":"Gao YQ,\nIhmsen H,\nHu ZY, et al. Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. 2023; 131(5):914\u2013920."},{"issue":"6","key":"i1878-7177-72-4-246-b04","series-title":"J Jpn Soc Clin Anesth","first-page":"589","article-title":"Three cases of complications following flumazenil administration\u2014hyperventilation, tonic convulsion and myoclonus epilepsy. Article in Japanese","volume":"13","author":"Yamakage M,","year":"1993","unstructured":"Yamakage M,\nNakano S,\nIwasaki H,\nKohro S,\nNamiki A. Three cases of complications following flumazenil administration\u2014hyperventilation, tonic convulsion and myoclonus epilepsy. Article in Japanese. J Jpn Soc Clin Anesth. 1993;13(6):589\u2013592."},{"key":"i1878-7177-72-4-246-b05","series-title":"Drug Des Devel Ther","first-page":"3413","article-title":"Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study","volume":"16","author":"Yang X,","year":"2022","unstructured":"Yang X,\nLin C,\nChen S, et al. Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study. Drug Des Devel Ther. 2022;16:3413\u20133420."},{"issue":"2","key":"i1878-7177-72-4-246-b06","series-title":"J Anesth","first-page":"265","article-title":"Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery","volume":"36","author":"Hari Y,","year":"2022","unstructured":"Hari Y,\nSatomi S,\nMurakami C, et al. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery. J Anesth. 2022;36(2):265\u2013269."},{"key":"i1878-7177-72-4-246-b01","series-title":"Pediatr Neurol","first-page":"18","article-title":"Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American consensus panel","volume":"68","author":"Wirrell EC,","year":"2017","unstructured":"Wirrell EC,\nLaux L,\nDonner E, et al. Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American consensus panel. Pediatr Neurol. 2017;68:18\u201334."},{"issue":"5","key":"i1878-7177-72-4-246-b02","series-title":"Brain Dev","first-page":"319","article-title":"The effectiveness of intravenous benzodiazepine for status epilepticus in Dravet syndrome","volume":"44","author":"Kikuchi K,","year":"2022","unstructured":"Kikuchi K,\nHamano S,\nMatsuura R, et al. The effectiveness of intravenous benzodiazepine for status epilepticus in Dravet syndrome. Brain Dev. 2022;44(5):319\u2013328."},{"issue":"5","key":"i1878-7177-72-4-246-b03","series-title":"Br J Anaesth","first-page":"914","article-title":"Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children","volume":"131","author":"Gao YQ,","year":"2023","unstructured":"Gao YQ,\nIhmsen H,\nHu ZY, et al. Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. Br J Anaesth. 2023; 131(5):914\u2013920."},{"issue":"6","key":"i1878-7177-72-4-246-b04","series-title":"J Jpn Soc Clin Anesth","first-page":"589","article-title":"Three cases of complications following flumazenil administration\u2014hyperventilation, tonic convulsion and myoclonus epilepsy. Article in Japanese","volume":"13","author":"Yamakage M,","year":"1993","unstructured":"Yamakage M,\nNakano S,\nIwasaki H,\nKohro S,\nNamiki A. Three cases of complications following flumazenil administration\u2014hyperventilation, tonic convulsion and myoclonus epilepsy. Article in Japanese. J Jpn Soc Clin Anesth. 1993;13(6):589\u2013592."},{"key":"i1878-7177-72-4-246-b05","series-title":"Drug Des Devel Ther","first-page":"3413","article-title":"Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study","volume":"16","author":"Yang X,","year":"2022","unstructured":"Yang X,\nLin C,\nChen S, et al. Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study. 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