{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:01:49Z","timestamp":1790283709530,"version":"4.1.0"},"reference-count":14,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    We compared the incidence of postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery under total intravenous anesthesia using propofol with and without ondansetron. Data on PONV within 24 hours after surgery, fentanyl and ondansetron dosing, demographic parameters, smoking history, and prior PONV were retrospectively extracted from the medical records of 291 patients. After propensity score matching, 78 patients were included in the ondansetron and control groups. The incidence of PONV was significantly lower in the ondansetron group (21%) than in the control group (36%;\n                    <jats:italic>P =<\/jats:italic>\n                    .033), whereas the incidence of postoperative headache was comparable. Ondansetron effectively reduced PONV without increasing headaches.\n                  <\/jats:p>","DOI":"10.2344\/24-0055","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:26:29Z","timestamp":1772810789000},"page":"48-50","source":"Crossref","is-referenced-by-count":2,"title":["Ondansetron Prevents Nausea and Vomiting After Orthognathic Surgery"],"prefix":"10.2344","volume":"73","author":[{"given":"Emi","family":"Fujioka","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hanamoto","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"},{"name":"Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Kozu","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Nagira","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"issue":"9","key":"i1878-7177-73-1-48-b01","series-title":"J Oral Maxillofac Surg","first-page":"1385","article-title":"Postoperative nausea and vomiting (PONV) after orthognathic surgery: a retrospective study and literature review","volume":"64","author":"Silva AC","year":"2006","unstructured":"Silva AC,\nO\u2019Ryan F,\nPoor DB. Postoperative nausea and vomiting (PONV) after orthognathic surgery: a retrospective study and literature review. J Oral Maxillofac Surg. 2006;64(9):1385\u20131397."},{"issue":"2","key":"i1878-7177-73-1-48-b02","series-title":"J Craniofac Surg","first-page":"584","article-title":"A comprehensive single-center analysis of postoperative nausea and vomiting following orthognathic surgery","volume":"33","author":"Pourtaheri N","year":"2022","unstructured":"Pourtaheri N,\nPeck CJ,\nManiskas S, et al. A comprehensive single-center analysis of postoperative nausea and vomiting following orthognathic surgery. J Craniofac Surg. 2022;33(2):584\u2013587."},{"issue":"1","key":"i1878-7177-73-1-48-b03","series-title":"BMC Anesthesiol","first-page":"162","article-title":"Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis","volume":"18","author":"Schraag S","year":"2018","unstructured":"Schraag S,\nPradelli L,\nAlsaleh AJO, et al. Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2018;18(1):162."},{"issue":"6","key":"i1878-7177-73-1-48-b04","series-title":"J Clin Anesth","first-page":"461","article-title":"Betamethasone in prevention of postoperative nausea and vomiting following breast surgery","volume":"26","author":"Olanders KJ","year":"2014","unstructured":"Olanders KJ,\nLundgren GA,\nJohansson AM. Betamethasone in prevention of postoperative nausea and vomiting following breast surgery. J Clin Anesth. 2014;26(6):461\u2013465."},{"issue":"10","key":"i1878-7177-73-1-48-b05","series-title":"Cochrane Database Syst Rev","first-page":"CD012859","article-title":"Drugs for preventing postoperative nausea and vomiting in adult after general anaesthesia: a network meta-analysis","volume":"10","author":"Weibel S","year":"2020","unstructured":"Weibel S,\nR\u00fccker G,\nEberhart LH, et al. Drugs for preventing postoperative nausea and vomiting in adult after general anaesthesia: a network meta-analysis. Cochrane Database Syst Rev. 2020;10(10):CD012859."},{"issue":"1","key":"i1878-7177-73-1-48-b06","series-title":"Stat Sci","first-page":"1","article-title":"Matching methods for causal inference: a review and a look forward","volume":"25","author":"Stuart EA.","year":"2010","unstructured":"Stuart EA. Matching methods for causal inference: a review and a look forward. Stat Sci. 2010;25(1):1\u201321."},{"issue":"1","key":"i1878-7177-73-1-48-b07","series-title":"Anesthesiology","first-page":"162","article-title":"Postoperative nausea and vomiting: its etiology, treatment, and prevention","volume":"77","author":"Watcha MF","year":"1992","unstructured":"Watcha MF,\nWhite PF. Postoperative nausea and vomiting: its etiology, treatment, and prevention. Anesthesiology. 1992; 77(1):162\u2013184."},{"issue":"9","key":"i1878-7177-73-1-48-b01","series-title":"J Oral Maxillofac Surg","first-page":"1385","article-title":"Postoperative nausea and vomiting (PONV) after orthognathic surgery: a retrospective study and literature review","volume":"64","author":"Silva AC","year":"2006","unstructured":"Silva AC,\nO\u2019Ryan F,\nPoor DB. Postoperative nausea and vomiting (PONV) after orthognathic surgery: a retrospective study and literature review. J Oral Maxillofac Surg. 2006;64(9):1385\u20131397."},{"issue":"2","key":"i1878-7177-73-1-48-b02","series-title":"J Craniofac Surg","first-page":"584","article-title":"A comprehensive single-center analysis of postoperative nausea and vomiting following orthognathic surgery","volume":"33","author":"Pourtaheri N","year":"2022","unstructured":"Pourtaheri N,\nPeck CJ,\nManiskas S, et al. A comprehensive single-center analysis of postoperative nausea and vomiting following orthognathic surgery. J Craniofac Surg. 2022;33(2):584\u2013587."},{"issue":"1","key":"i1878-7177-73-1-48-b03","series-title":"BMC Anesthesiol","first-page":"162","article-title":"Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis","volume":"18","author":"Schraag S","year":"2018","unstructured":"Schraag S,\nPradelli L,\nAlsaleh AJO, et al. Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2018;18(1):162."},{"issue":"6","key":"i1878-7177-73-1-48-b04","series-title":"J Clin Anesth","first-page":"461","article-title":"Betamethasone in prevention of postoperative nausea and vomiting following breast surgery","volume":"26","author":"Olanders KJ","year":"2014","unstructured":"Olanders KJ,\nLundgren GA,\nJohansson AM. Betamethasone in prevention of postoperative nausea and vomiting following breast surgery. J Clin Anesth. 2014;26(6):461\u2013465."},{"issue":"10","key":"i1878-7177-73-1-48-b05","series-title":"Cochrane Database Syst Rev","first-page":"CD012859","article-title":"Drugs for preventing postoperative nausea and vomiting in adult after general anaesthesia: a network meta-analysis","volume":"10","author":"Weibel S","year":"2020","unstructured":"Weibel S,\nR\u00fccker G,\nEberhart LH, et al. Drugs for preventing postoperative nausea and vomiting in adult after general anaesthesia: a network meta-analysis. Cochrane Database Syst Rev. 2020;10(10):CD012859."},{"issue":"1","key":"i1878-7177-73-1-48-b06","series-title":"Stat Sci","first-page":"1","article-title":"Matching methods for causal inference: a review and a look forward","volume":"25","author":"Stuart EA.","year":"2010","unstructured":"Stuart EA. Matching methods for causal inference: a review and a look forward. Stat Sci. 2010;25(1):1\u201321."},{"issue":"1","key":"i1878-7177-73-1-48-b07","series-title":"Anesthesiology","first-page":"162","article-title":"Postoperative nausea and vomiting: its etiology, treatment, and prevention","volume":"77","author":"Watcha MF","year":"1992","unstructured":"Watcha MF,\nWhite PF. Postoperative nausea and vomiting: its etiology, treatment, and prevention. 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