{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:03:38Z","timestamp":1792825418556,"version":"4.5.0"},"reference-count":41,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine via primary intraosseous (IO) injection with the QuickSleeper device vs inferior alveolar nerve block (IANB) for mandibular first molars diagnosed with symptomatic irreversible pulpitis (SIP).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Sixty-four patients with a first mandibular molar with SIP were randomly divided into 2 groups: IO (n = 32) and IANB (n = 32). Each received either an IO injection with the 5th generation QuickSleeper device or a conventional IANB with 1.7 mL 4% articaine with 1:100,000 epinephrine. Success was defined as no\/mild pain upon the access cavity preparation and initial filing. Injection pain, anesthetic onset, heart rate (HR) change, HR recovery time, and duration of anesthesia were also recorded and analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The success rates were 40.6% for IANB and 81.2% for IO (<jats:italic>P<\/jats:italic> &lt; .001). IO exhibited a significantly lower injection pain (<jats:italic>P<\/jats:italic> = .027), a shorter onset of action (<jats:italic>P<\/jats:italic> &lt; .001), a greater heart rate increase (<jats:italic>P<\/jats:italic> &lt; .001), a faster heart rate recovery time (<jats:italic>P<\/jats:italic> &lt; .001), and a shorter duration of action (<jats:italic>P<\/jats:italic> &lt; .001) vs IANB.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Primary IO anesthesia using the fifth generation of the QuickSleeper device was more successful than IANB when using 4% articaine with 1:100,000 epinephrine to anesthetize mandibular first molars with SIP. The QuickSleeper device appeared to be a viable alternative to IANB for mandibular anesthesia.<\/jats:p>\n<\/jats:sec>","DOI":"10.2344\/363591","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:07:04Z","timestamp":1725880024000},"page":"123-130","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of QuickSleeper Intraosseous Injection of 4% Articaine in Mandibular First Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial"],"prefix":"10.2344","volume":"71","author":[{"given":"Mohammadreza","family":"Vatankhah","sequence":"first","affiliation":[{"name":"Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Dianat","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Advanced Oral Sciences and Therapeutics, University of Maryland, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid Gharibian","family":"Bejestani","sequence":"additional","affiliation":[{"name":"Dentist, Private Office, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Akbarzadeh","family":"Baghban","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Shojaeian","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"issue":"1","key":"i1878-7177-71-3-123-b01","series-title":"Br Dent J","first-page":"15","article-title":"How to overcome failed local anaesthesia","volume":"186","author":"Meechan JG.","year":"1999","unstructured":"Meechan JG. 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