{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:30:08Z","timestamp":1779895808034,"version":"3.53.1"},"reference-count":16,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Pfeiffer syndrome (PS) is a rare inherited disorder that affects the craniofacial and extremity bones but can also include anomalies of the upper and lower airways. Among the 3 subtypes, PS types 2 and 3 are the most severe. We describe the anesthetic management of a 10-year-old boy with PS type 2 scheduled for dental treatment under general anesthesia. Because of his history of Chiari malformation, avoiding neck hyperextension was recommended to prevent worsening of his neurologic function. Preoperative computed tomography revealed significant nasal stenosis but no tracheal anomalies. Considering the difficulty of nasotracheal intubation, we planned for an oral intubation. General anesthesia was induced using sevoflurane, nitrous oxide, and oxygen along with an oropharyngeal airway. After lidocaine was topically applied to the oropharynx, fiber-optic orotracheal intubation was performed under spontaneous ventilation to minimize head and neck movement. Anesthesia was maintained using desflurane and remifentanil, and no postoperative complications were observed. General anesthesia for patients with PS requires careful planning, which should include preoperative assessment of the airway to determine the feasibility of nasotracheal intubation and identify airway irregularities.<\/jats:p>","DOI":"10.2344\/523400","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T11:06:32Z","timestamp":1725879992000},"page":"140-144","source":"Crossref","is-referenced-by-count":1,"title":["Anesthetic Management of a Pediatric Patient With Pfeiffer Syndrome"],"prefix":"10.2344","volume":"71","author":[{"given":"Emiko","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Owada","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Wajima","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Iwahori","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gentaro","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asako","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Shionoya","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, The Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i1878-7177-71-3-140-b01","series-title":"Z Kinderheilkd","first-page":"301","article-title":"Dominant hereditary acrocephalosyndactylia","volume":"90","author":"Pfeiffer RA.","year":"1964","unstructured":"Pfeiffer RA. Dominant hereditary acrocephalosyndactylia. Z Kinderheilkd. 1964;90:301\u2013320."},{"key":"i1878-7177-71-3-140-b02","series-title":"Hum Mol Genet","first-page":"323","article-title":"Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome","volume":"4","author":"Schell U,","year":"1995","unstructured":"Schell U,Hehr A,Feldman GJ, et al. Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome. Hum Mol Genet. 1995;4:323\u2013328."},{"key":"i1878-7177-71-3-140-b03","series-title":"Orphanet J Rare Dis","first-page":"19","article-title":"Pfeiffer syndrome","volume":"1","author":"Vogels A,","year":"2006","unstructured":"Vogels A,Fryns JP. Pfeiffer syndrome. Orphanet J Rare Dis. 2006;1:19."},{"key":"i1878-7177-71-3-140-b04","series-title":"Plast Reconstr Surg","first-page":"1560","article-title":"Pfeiffer syndrome: a treatment evaluation","volume":"123","author":"Fearon JA,","year":"2009","unstructured":"Fearon JA,Rhodes J. 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Childs Nerv Syst. 2005;21:889\u2013901."},{"key":"i1878-7177-71-3-140-b13","series-title":"Clin Case Rep","first-page":"e05194","article-title":"Anesthetic management in a patient with Arnold-Chiari malformation type 1,5: a case report","volume":"10","author":"Coviello A,","year":"2022","unstructured":"Coviello A,Golino L,Posillipo C,Marra A,Togn\u00f9 A,Servillo G. Anesthetic management in a patient with Arnold-Chiari malformation type 1,5: a case report. Clin Case Rep. 2022;10:e05194."},{"key":"i1878-7177-71-3-140-b14","series-title":"Paediatr Anaesth","first-page":"1316","article-title":"Perioperative airway complications in infants and children with Crouzon and Pfeiffer syndromes: a single-center experience","volume":"31","author":"Venkat Raman V,","year":"2021","unstructured":"Venkat Raman V,de Beer D. Perioperative airway complications in infants and children with Crouzon and Pfeiffer syndromes: a single-center experience. Paediatr Anaesth. 2021;31:1316\u20131324."},{"key":"i1878-7177-71-3-140-b15","series-title":"Laryngoscope","first-page":"1213","article-title":"Congenital tracheal cartilaginous sleeve","volume":"105","author":"Lin SY,","year":"1995","unstructured":"Lin SY,Chen JC,Hotaling AJ,Holinger LD. Congenital tracheal cartilaginous sleeve. Laryngoscope. 1995;105:1213\u20131219."},{"key":"i1878-7177-71-3-140-b16","series-title":"J Pediatr Surg","first-page":"1438","article-title":"Tracheal cartilaginous sleeve in patients with craniosynostosis syndromes: a meta-analysis","volume":"45","author":"Lertsburapa K,","year":"2010","unstructured":"Lertsburapa K,Schroeder JW Jr,Sullivan C. Tracheal cartilaginous sleeve in patients with craniosynostosis syndromes: a meta-analysis. J Pediatr Surg. 2010;45:1438\u20131444."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/3\/article-p140.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/3\/article-p140.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/3\/article-p140.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:30:21Z","timestamp":1730939421000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/3\/article-p140.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":16,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2344\/523400","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}