{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:15:39Z","timestamp":1728360939233},"reference-count":23,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>We report on a morbidly obese 16-year-old boy (weight, 116 kg; height, 176 cm; body mass index, 35.5 kg\/m<jats:sup>2<\/jats:sup>) with mitochondrial encephalomyopathy and a history of cerebral infarction, epilepsy, and severe mental retardation. The patient was scheduled for elective surgery under general anesthesia for multiple dental caries and entropion of the left eye. Preoperative examination results, including an electrocardiogram, were normal. No obvious cardiac function abnormalities were observed on echocardiography. Midazolam (10 mg) was administered orally as premedication 30 minutes before transfer to the operating room; however, the patient was uncooperative, and his body movements were difficult to control upon entering the operating room. This complicated our attempts to establish a peripheral intravenous line and necessitated volatile inhalational induction, followed by maintenance using total intravenous anesthesia. General anesthesia was used to minimize metabolic system stress. We did not use an infusion solution containing sodium lactate. The operation and subsequent clinical course until discharge were uneventful. Because aerobic metabolism is already compromised in patients with mitochondrial encephalomyopathy, anesthetic management should be designed to avoid placing additional stress on the metabolic system.<\/jats:p>","DOI":"10.2344\/anpr-64-03-06","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T21:45:00Z","timestamp":1512423900000},"page":"235-239","source":"Crossref","is-referenced-by-count":2,"title":["Anesthetic Management in Mitochondrial Encephalomyopathy: A Case Report"],"prefix":"10.2344","volume":"64","author":[{"given":"Toru","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-64-4-235-b01","series-title":"J Child Neurol","first-page":"4","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): current concepts","volume":"9","author":"Hirano \n              M,","year":"1994","unstructured":"Hirano \n              M, \n            \n            \n              Pavlakis \n              SG. \n            \n          \n          Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): current concepts. 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AANA J. 2013;81:237\u2013243."},{"key":"i0003-3006-64-4-235-b03","series-title":"Paediatr Anaesth","first-page":"453","article-title":"Anaesthesia for an adolescent with mitochondrial encephalopathy-lactic acidosis-stroke-like episodes syndrome","volume":"13","author":"Bolton \n              P,","year":"2003","unstructured":"Bolton \n              P, \n            \n            \n              Peutrell \n              J, \n            \n            \n              Zuberi \n              S, \n            \n            \n              Robinson \n              P. \n            \n          \n          Anaesthesia for an adolescent with mitochondrial encephalopathy-lactic acidosis-stroke-like episodes syndrome. 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Ann Fr Anesth Reanim. 2013;32:e149."},{"key":"i0003-3006-64-4-235-b10","series-title":"Paediatr Anaesth","first-page":"22","article-title":"The risk of malignant hyperthermia in children undergoing muscle biopsy for suspected neuromuscular disorder","volume":"17","author":"Flick \n              RP,","year":"2007","unstructured":"Flick \n              RP, \n            \n            \n              Gleich \n              SJ, \n            \n            \n              Herr \n              MM, \n            \n            \n              Wedel \n              DJ. \n            \n          \n          The risk of malignant hyperthermia in children undergoing muscle biopsy for suspected neuromuscular disorder. Paediatr Anaesth. 2007;17:22\u201327."},{"key":"i0003-3006-64-4-235-b11","series-title":"Pharm Res","first-page":"2639","article-title":"Transduction of human recombinant proteins into mitochondria as a protein therapeutic approach for mitochondrial disorders","volume":"28","author":"Papadopoulou \n              LC,","year":"2011","unstructured":"Papadopoulou \n              LC, \n            \n            \n              Tsiftsoglou \n              AS. \n            \n          \n          Transduction of human recombinant proteins into mitochondria as a protein therapeutic approach for mitochondrial disorders. Pharm Res. 2011;28:2639\u20132656."},{"key":"i0003-3006-64-4-235-b12","series-title":"Paediatr Anaesth","first-page":"1","article-title":"Muscular dystrophy versus mitochondrial myopathy: the dilemma of the undiagnosed hypotonic child","volume":"17","author":"Allison \n              KR.","year":"2007","unstructured":"Allison \n              KR. \n            \n          \n          Muscular dystrophy versus mitochondrial myopathy: the dilemma of the undiagnosed hypotonic child. Paediatr Anaesth. 2007;17:1\u20136."},{"key":"i0003-3006-64-4-235-b13","series-title":"B C Med J","first-page":"183","article-title":"Mitochondrial disease clinical manifestations: an overview","volume":"53","author":"Mattman \n              A,","year":"2011","unstructured":"Mattman \n              A, \n            \n            \n              Sirrs \n              S, \n            \n            \n              Mezei \n              MM, \n            \n            \n              Salvarinova-Zivkovic \n              R, \n            \n            \n              Alfadhel \n              M, \n            \n            \n              Lillquist \n              Y. \n            \n          \n          Mitochondrial disease clinical manifestations: an overview. B C Med J. 2011;53:183\u2013187."},{"key":"i0003-3006-64-4-235-b14","series-title":"Intensive Care Med","first-page":"1417","article-title":"The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome","volume":"29","author":"Vasile \n              B,","year":"2003","unstructured":"Vasile \n              B, \n            \n            \n              Rasulo \n              F, \n            \n            \n              Candiani \n              A, \n            \n            \n              Latronico \n              N. \n            \n          \n          The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med. 2003;29:1417\u20131425."},{"key":"i0003-3006-64-4-235-b15","series-title":"Lancet","first-page":"606","article-title":"Impaired fatty acid oxidation in propofol infusion syndrome","volume":"357","author":"Wolf \n              A,","year":"2001","unstructured":"Wolf \n              A, \n            \n            \n              Weir \n              P, \n            \n            \n              Segar \n              P, \n            \n            \n              Stone \n              J, \n            \n            \n              Shield \n              J. \n            \n          \n          Impaired fatty acid oxidation in propofol infusion syndrome. 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J Anesth. 2007;21:72\u201375."},{"key":"i0003-3006-64-4-235-b17","series-title":"Anesth Analg","first-page":"95","article-title":"Modified rapid sequence induction and intubation: a survey of United States current practice","volume":"115","author":"Ehrenfeld \n              JM,","year":"2012","unstructured":"Ehrenfeld \n              JM, \n            \n            \n              Cassedy \n              EA, \n            \n            \n              Forbes \n              VE, \n            \n            \n              Mercaldo \n              ND, \n            \n            \n              Sandberg \n              WS. \n            \n          \n          Modified rapid sequence induction and intubation: a survey of United States current practice. Anesth Analg. 2012;115:95\u2013101."},{"key":"i0003-3006-64-4-235-b18","series-title":"Anaesthesia","first-page":"60","article-title":"The effect of neuromuscular blockade on the efficiency of mask ventilation of the lungs","volume":"58","author":"Goodwin \n              MW,","year":"2003","unstructured":"Goodwin \n              MW, \n            \n            \n              Pandit \n              JJ, \n            \n            \n              Hames \n              K, \n            \n            \n              Popat \n              M, \n            \n            \n              Yentis \n              SM. \n            \n          \n          The effect of neuromuscular blockade on the efficiency of mask ventilation of the lungs. Anaesthesia. 2003;58:60\u201363."},{"key":"i0003-3006-64-4-235-b19","series-title":"Should anaesthetists have to demonstrate that face mask ventilation is possible before giving a neuromuscular blocker? 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Anaesthesia. 2011;66:163\u2013167."},{"key":"i0003-3006-64-4-235-b21","series-title":"Anesthesiology","first-page":"487","article-title":"Effects of muscle relaxants on mask ventilation in anesthetized persons with normal upper airway anatomy","volume":"117","author":"Ikeda \n              A,","year":"2012","unstructured":"Ikeda \n              A, \n            \n            \n              Isono \n              S, \n            \n            \n              Sato \n              Y, \n            \n            et al. \n          Effects of muscle relaxants on mask ventilation in anesthetized persons with normal upper airway anatomy. 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