{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:16:00Z","timestamp":1728360960896},"reference-count":21,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Hypertensive patients receiving nonselective \u03b2-adrenergic antagonists are vulnerable to hypertension and bradycardia when injected with dental local anesthetic formulations containing epinephrine. Dexmedetomidine (DEX), an \u03b1<jats:sub>2<\/jats:sub>-adrenergic agonist, has been reported to prolong and enhance the local anesthetic effects of lidocaine. The cardiovascular effects of the DEX-lidocaine combination have not yet been investigated in the presence of nonselective \u03b2-adrenergic antagonists. Therefore, we assessed the cardiovascular effects of the DEX-lidocaine combination in spontaneously hypertensive rats (SHR) treated with a nonselective \u03b2-adrenergic antagonist (propranolol). We injected propranolol-treated rats with various concentrations of DEX alone, 100 \u03bcg\/kg epinephrine alone, or 5 \u03bcg\/kg DEX combined with 2% lidocaine and measured their blood pressure (BP) and heart rates (HR) to assess the cardiovascular effects. The BP of propranolol-treated SHR was significantly increased by treatment with 100 \u03bcg\/kg epinephrine alone. The BP and HR of propranolol-treated SHR were not significantly changed by treatment with low concentrations of DEX, but they were significantly decreased by treatment with a high concentration of DEX (50 \u03bcg\/kg). Moreover, there was no significant difference in the BP and HR of propranolol-treated SHR after the injection of a combination of 5 \u03bcg\/kg DEX and 2% lidocaine. Thus, the DEX-lidocaine combination may be an acceptable addition to dental local anesthetic solutions from a cardiovascular standpoint for hypertensive patients receiving nonselective \u03b2-adrenergic antagonists.<\/jats:p>","DOI":"10.2344\/anpr-64-04-09","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T21:45:00Z","timestamp":1512423900000},"page":"221-225","source":"Crossref","is-referenced-by-count":1,"title":["A Combination of Dexmedetomidine and Lidocaine Is a Cardiovascularly Safe Dental Local Anesthetic for Hypertensive Rats Treated With a Nonselective \u03b2-Adrenergic Antagonist"],"prefix":"10.2344","volume":"64","author":[{"given":"Yukako","family":"Tsutsui","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-64-4-221-b01","series-title":"Anesthesiology","first-page":"1035","article-title":"Cardiovascular effect of low-dose epinephrine infusions in relation to the extent of preoperative beta-adrenoceptor blockade","volume":"74","author":"Tarnow \n              J,","year":"1991","unstructured":"Tarnow \n              J, \n            \n            \n              M\u00fcller \n              RK. \n            \n          \n          Cardiovascular effect of low-dose epinephrine infusions in relation to the extent of preoperative beta-adrenoceptor blockade. 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