{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:23:03Z","timestamp":1773663783619,"version":"3.50.1"},"reference-count":19,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Recent reports have stated that dexmedetomidine (DEX), an \u03b1<jats:sub>2<\/jats:sub>-adrenoreceptor agonist, enhances the local anesthetic effects of ropivacaine and prolongs its effective duration. However, little is known about the effect of a combination of DEX and lidocaine on anesthetic duration. Therefore, we investigated whether DEX can prolong the local anesthetic effect of lidocaine, using the thermal paw withdrawal test in Wistar rats in order to measure local anesthetic duration. We subcutaneously injected 50 \u03bcL of either normal saline, 2% lidocaine, a combination of 0.5 \u03bcg\/kg DEX and 2% lidocaine, or a combination of 2% lidocaine with 1:80,000 epinephrine into the plantar surface of the left hind paw of the rats. The plantar region was stimulated using heat. We measured the perceived acute pain according to paw movement in response to stimulation. We found DEX significantly prolonged the paw withdrawal latency of lidocaine. Moreover, we found that DEX can prolong the local anesthetic duration of lidocaine as much as 1:80,000 epinephrine, up to 35 minutes after injection. In conclusion, this study concluded that a combination of DEX and lidocaine may be useful as a local anesthetic, similar to a combination of epinephrine and lidocaine, for short procedures.<\/jats:p>","DOI":"10.2344\/anpr-65-01-08","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T21:45:00Z","timestamp":1512423900000},"page":"230-234","source":"Crossref","is-referenced-by-count":3,"title":["Dexmedetomidine Increases the Latency of Thermal Antinociception in Rats"],"prefix":"10.2344","volume":"64","author":[{"given":"Yukako","family":"Tsutsui","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, The Nippon Dental University School of Life Dentistry at Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-64-4-230-b01","series-title":"Anesthesiology","first-page":"502","article-title":"Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat","volume":"109","author":"Brummett \n              CM,","year":"2008","unstructured":"Brummett \n              CM, \n            \n            \n              Norat \n              MA, \n            \n            \n              Palmisano \n              JM, \n            \n            \n              Lydic \n              R. \n            \n          \n          Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. 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Pain. 1988;32:77\u201388."},{"key":"i0003-3006-64-4-230-b10","series-title":"J Pharmacol Sci","first-page":"9","article-title":"Contribution of TRPV1 receptor-expressing fibers to spinal ventral root after-discharges and mechanical hyperalgesia in a spared nerve injury (SNI) rat model","volume":"121","author":"Yamamoto \n              S,","year":"2013","unstructured":"Yamamoto \n              S, \n            \n            \n              Ohsawa \n              M, \n            \n            \n              Ono \n              H. \n            \n          \n          Contribution of TRPV1 receptor-expressing fibers to spinal ventral root after-discharges and mechanical hyperalgesia in a spared nerve injury (SNI) rat model. 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Curr Opin Crit Care. 2001;7:221\u2013226."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/64\/4\/article-p230.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/64\/4\/230\/2103118\/anpr-65-01-08.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/64\/4\/article-p230.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/64\/4\/article-p230.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:36:28Z","timestamp":1728304588000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/64\/4\/article-p230.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":19,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2344\/anpr-65-01-08","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"value":"0003-3006","type":"print"},{"value":"1878-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}