{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:20:30Z","timestamp":1770697230059,"version":"3.49.0"},"reference-count":29,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"To compare the success of perceived pulpal anesthesia between groups using nitrous oxide\/oxygen (N2<\/jats:sub>O\/O2<\/jats:sub>) and oxygen (O2<\/jats:sub>) in children premedicated with ibuprofen with symptomatic irreversible pulpitis permanent teeth. Thirty-three children (mean age 10.4 \u00b1 1.9 years) with 33 symptomatic irreversible pulpitis permanent teeth were included in this preliminary study. All children were premedicated with ibuprofen and randomly assigned to receive either N2<\/jats:sub>O\/O2<\/jats:sub> (17 participants) or O2<\/jats:sub> (16 participants). Four percent articaine with epinephrine 1:100,000 was administered, and vital pulp therapy was performed. Children used the Wong-Baker FACES Pain Rating Scale (WBFPS) to report their pain at baseline as well as during carious dentin removal, pulpal exposure, and pulpal tissue removal steps. The success was determined when the reported WBFPS score was \u22644. The chi-square test was used to compare the success between both groups. The success of pulpal anesthesia was 71% (12\/17) and 19% (3\/16) in the N2<\/jats:sub>O\/O2<\/jats:sub> and O2<\/jats:sub> groups, respectively. The success in the N2<\/jats:sub>O\/O2<\/jats:sub> group was 52% higher than that in the O2<\/jats:sub> group (confidence interval = 22.9% to 80.7%; significant difference p<\/jats:italic> = .003). From the result of this preliminary study, N2<\/jats:sub>O\/O2<\/jats:sub> significantly increased the success of perceived pulpal anesthesia in children premedicated with ibuprofen with symptomatic irreversible pulpitis permanent teeth. However, further study with a larger sample is required to confirm this result.<\/jats:p>","DOI":"10.2344\/anpr-65-02-08","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T21:21:11Z","timestamp":1537478471000},"page":"156-161","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Nitrous Oxide on Pulpal Anesthesia: A Preliminary Study"],"prefix":"10.2344","volume":"65","author":[{"given":"Papimon","family":"Chompu-inwai","sequence":"first","affiliation":[{"name":"Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophon","family":"Simprasert","sequence":"additional","affiliation":[{"name":"Former postgraduate student in pediatric dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patchanee","family":"Chuveera","sequence":"additional","affiliation":[{"name":"Department of Family and Community Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areerat","family":"Nirunsittirat","sequence":"additional","affiliation":[{"name":"Department of Family and Community Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanapat","family":"Sastraruji","sequence":"additional","affiliation":[{"name":"Dental Research Center, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanida","family":"Srisuwan","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-65-3-156-b01","series-title":"Int Endod J","first-page":"222","article-title":"Efficacy of single buccal infiltrations for maxillary first molars in patients with irreversible pulpitis: a randomized controlled clinical trial","volume":"47","year":"2014","unstructured":"Atasoy Ulusoy OI, Alacam T. Efficacy of single buccal infiltrations for maxillary first molars in patients with irreversible pulpitis: a randomized controlled clinical trial. Int Endod J. 2014;47:222\u2013227."},{"key":"i0003-3006-65-3-156-b02","series-title":"J Endod","first-page":"487","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"Nusstein \n J,","year":"1998","unstructured":"Nusstein \n J, \n \n \n Reader \n A, \n \n \n Nist \n R, \n \n \n Beck \n M, \n \n \n Meyers \n WJ. \n \n \n Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis. J Endod. 1998;24:487\u2013491."},{"key":"i0003-3006-65-3-156-b03","series-title":"J Endod","first-page":"568","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"30","author":"Claffey \n E,","year":"2004","unstructured":"Claffey \n E, \n \n \n Reader \n A, \n \n \n Nusstein \n J, \n \n \n Beck \n M, \n \n \n Weaver \n J. \n \n \n Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis. J Endod. 2004;30:568\u2013571."},{"key":"i0003-3006-65-3-156-b04","series-title":"J Endod","first-page":"165","article-title":"A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis","volume":"35","author":"Tortamano \n IP,","year":"2009","unstructured":"Tortamano \n IP, \n \n \n Siviero \n M, \n \n \n Costa \n CG, \n \n \n Buscariolo \n IA, \n \n \n Armonia \n PL. \n \n \n A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis. J Endod. 2009;35:165\u2013168."},{"key":"i0003-3006-65-3-156-b05","series-title":"Successful Local Anesthesia for Restorative Dentistry and Endodontics. Vol 1","author":"Reader \n A,","year":"2011","unstructured":"Reader \n A, \n \n \n Nusstein \n J, \n \n \n Drum \n M. \n \n \n Successful Local Anesthesia for Restorative Dentistry and Endodontics. Vol 1. Hanover Park, IL: Quintessence;2011."},{"key":"i0003-3006-65-3-156-b06","series-title":"J Endod","first-page":"160","article-title":"Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial","volume":"39","author":"Shahi \n S,","year":"2013","unstructured":"Shahi \n S, \n \n \n Mokhtari \n H, \n \n \n Rahimi \n S, \n \n et al. \n Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial. J Endod. 2013;39:160\u2013162."},{"key":"i0003-3006-65-3-156-b07","series-title":"J Endod","first-page":"593","article-title":"Effect of combination of preoperative ibuprofen\/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"37","author":"Simpson \n M,","year":"2011","unstructured":"Simpson \n M, \n \n \n Drum \n M, \n \n \n Nusstein \n J, \n \n \n Reader \n A, \n \n \n Beck \n M. \n \n \n Effect of combination of preoperative ibuprofen\/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis. J Endod. 2011;37:593\u2013597."},{"key":"i0003-3006-65-3-156-b08","series-title":"J Endod","first-page":"375378","article-title":"Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial","volume":"36","author":"Aggarwal \n V,","year":"2010","unstructured":"Aggarwal \n V, \n \n \n Singla \n M, \n \n \n Kabi \n D. \n \n \n Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial. J Endod. 2010;36:375378."},{"key":"i0003-3006-65-3-156-b09","series-title":"J Endod","first-page":"379","article-title":"Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"36","author":"Oleson \n M,","year":"2010","unstructured":"Oleson \n M, \n \n \n Drum \n M, \n \n \n Reader \n A, \n \n \n Nusstein \n J, \n \n \n Beck \n M. \n \n \n Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod. 2010;36:379\u2013382."},{"key":"i0003-3006-65-3-156-b10","series-title":"Quintessence Int","first-page":"209","article-title":"Preoperative oral nonsteroidal anti-inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta-analysis based on randomized controlled trials","volume":"43","author":"Li \n C,","year":"2012","unstructured":"Li \n C, \n \n \n Yang \n X, \n \n \n Ma \n X, \n \n \n Li \n L, \n \n \n Shi \n Z. \n \n \n Preoperative oral nonsteroidal anti-inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta-analysis based on randomized controlled trials. Quintessence Int. 2012;43:209\u2013219."},{"key":"i0003-3006-65-3-156-b11","series-title":"Dent Clin North Am","first-page":"237","article-title":"Local anesthesia strategies for the patient with a \u201chot\u201d tooth","volume":"54","author":"Nusstein \n JM,","year":"2010","unstructured":"Nusstein \n JM, \n \n \n Reader \n A, \n \n \n Drum \n M. \n \n \n Local anesthesia strategies for the patient with a \u201chot\u201d tooth. Dent Clin North Am. 2010;54:237\u2013247."},{"key":"i0003-3006-65-3-156-b12","series-title":"J Endod","first-page":"1450","article-title":"The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis","volume":"36","author":"Parirokh \n M,","year":"2010","unstructured":"Parirokh \n M, \n \n \n Ashouri \n R, \n \n \n Rekabi \n AR, \n \n et al. \n The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. J Endod. 2010;36:1450\u20131454."},{"key":"i0003-3006-65-3-156-b13","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol","first-page":"399","article-title":"The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth","volume":"102","author":"Modaresi \n J,","year":"2006","unstructured":"Modaresi \n J, \n \n \n Dianat \n O, \n \n \n Mozayeni \n MA. \n \n \n The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2006;102:399\u2013403."},{"key":"i0003-3006-65-3-156-b14","series-title":"J Endod","first-page":"565","article-title":"Effect of nitrous oxide on the efficacy of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"38","author":"Stanley \n W,","year":"2012","unstructured":"Stanley \n W, \n \n \n Drum \n M, \n \n \n Nusstein \n J, \n \n \n Reader \n A, \n \n \n Beck \n M. \n \n \n Effect of nitrous oxide on the efficacy of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis. J Endod. 2012;38:565\u2013569."},{"key":"i0003-3006-65-3-156-b15","series-title":"J Dent Res","first-page":"694","article-title":"Effect of aging on the nerve supply to human teeth","volume":"46","author":"Bernick \n S.","year":"1967","unstructured":"Bernick \n S. \n \n \n Effect of aging on the nerve supply to human teeth. J Dent Res. 1967;46:694\u2013699."},{"key":"i0003-3006-65-3-156-b16","series-title":"J Endod","first-page":"88","article-title":"Effect of aging on the human pulp","volume":"1","author":"Bernick \n S,","year":"1975","unstructured":"Bernick \n S, \n \n \n Nedelman \n C. \n \n \n Effect of aging on the human pulp. J Endod. 1975;1:88\u201394."},{"key":"i0003-3006-65-3-156-b17","series-title":"Pediatr Dent","first-page":"E174","article-title":"Guideline on use of nitrous oxide for pediatric dental patients","volume":"35","year":"2013","unstructured":"American Academy of Pediatric Dentistry. Guideline on use of nitrous oxide for pediatric dental patients. Pediatr Dent. 2013;35:E174\u2013E178."},{"key":"i0003-3006-65-3-156-b18","series-title":"Pediatrics","first-page":"e1168","article-title":"A systematic review of faces scales for the self-report of pain intensity in children","volume":"126","author":"Tomlinson \n D,","year":"2010","unstructured":"Tomlinson \n D, \n \n \n von Baeyer \n CL, \n \n \n Stinson \n JN, \n \n \n Sung \n L. \n \n \n A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics. 2010;126:e1168\u2013e1198."},{"key":"i0003-3006-65-3-156-b19","series-title":"Pain","first-page":"25","article-title":"A comparison of faces scales for the measurement of pediatric pain: children's and parents' ratings","volume":"83","author":"Chambers \n CT,","year":"1999","unstructured":"Chambers \n CT, \n \n \n Giesbrecht \n K, \n \n \n Craig \n KD, \n \n \n Bennett \n SM, \n \n \n Huntsman \n E. \n \n \n A comparison of faces scales for the measurement of pediatric pain: children's and parents' ratings. Pain. 1999;83:25\u201335."},{"key":"i0003-3006-65-3-156-b20","series-title":"Clin J Pain","first-page":"277","article-title":"Faces scales for the measurement of postoperative pain intensity in children following minor surgery","volume":"21","author":"Chambers \n CT,","year":"2005","unstructured":"Chambers \n CT, \n \n \n Hardial \n J, \n \n \n Craig \n KD, \n \n \n Court \n C, \n \n \n Montgomery \n C. \n \n \n Faces scales for the measurement of postoperative pain intensity in children following minor surgery. Clin J Pain. 2005;21:277\u2013285."},{"key":"i0003-3006-65-3-156-b21","series-title":"Int J Paediatr Dent","first-page":"47","article-title":"Validation of a Facial Image Scale to assess child dental anxiety","volume":"12","author":"Buchanan \n H,","year":"2002","unstructured":"Buchanan \n H, \n \n \n Niven \n N. \n \n \n Validation of a Facial Image Scale to assess child dental anxiety. Int J Paediatr Dent. 2002;12:47\u201352."},{"key":"i0003-3006-65-3-156-b22","series-title":"Create a blocked randomisation list","article-title":"Sealed Envelope Ltd","year":"2014","unstructured":"Sealed Envelope Ltd. Create a blocked randomisation list. Available at: https:\/\/www.sealedenvelope.com\/simple-randomiser\/v1\/lists. Accessed May 10,2014."},{"issue":"3","key":"i0003-3006-65-3-156-b23","series-title":"Br Dent J","first-page":"E7","article-title":"Highly anxious dental patients report more pain during dental injections","volume":"205","author":"van Wijk \n AJ,","year":"2008","unstructured":"van Wijk \n AJ, \n \n \n Makkes \n PC. \n \n \n Highly anxious dental patients report more pain during dental injections. Br Dent J. 2008;205(3):E7."},{"key":"i0003-3006-65-3-156-b24","series-title":"Handbook of Nitrous Oxide and Oxygen Sedation","author":"Clark \n MS,","year":"2008","unstructured":"Clark \n MS, \n \n \n Brunick \n AL. \n \n \n Handbook of Nitrous Oxide and Oxygen Sedation. St Louis, MO: Mosby, Elsevier;2008."},{"key":"i0003-3006-65-3-156-b25","series-title":"BMJ","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs)","author":"Day \n RO,","year":"2013","unstructured":"Day \n RO, \n \n \n Graham \n GG. \n \n \n Non-steroidal anti-inflammatory drugs (NSAIDs). BMJ. 2013;346:f3195."},{"key":"i0003-3006-65-3-156-b26","series-title":"Anesth Prog","first-page":"9","article-title":"Advances in understanding the actions of nitrous oxide","volume":"54","author":"Emmanouil \n DE,","year":"2007","unstructured":"Emmanouil \n DE, \n \n \n Quock \n RM. \n \n \n Advances in understanding the actions of nitrous oxide. Anesth Prog. 2007;54:9\u201318."},{"key":"i0003-3006-65-3-156-b27","series-title":"Pain Res Manage","first-page":"309","article-title":"Nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: a dose-dependent effect","volume":"20","author":"Ben Boujema \n M,","year":"2015","unstructured":"Ben Boujema \n M, \n \n \n Laboureyras \n E, \n \n \n Pype \n J, \n \n \n Bessiere \n B, \n \n \n Simonnet \n G. \n \n \n Nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: a dose-dependent effect. Pain Res Manage. 2015;20:309\u2013315."},{"key":"i0003-3006-65-3-156-b28","series-title":"Int J Surg","first-page":"672","article-title":"Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"9","author":"Schulz \n KF,","year":"2011","unstructured":"Schulz \n KF, \n \n \n Altman \n DG, \n \n \n Moher \n D, \n \n \n Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg. 2011;9:672\u2013677."},{"key":"i0003-3006-65-3-156-b29","series-title":"ISRN Dent","first-page":"247","article-title":"A comparison of two pain scales in the assessment of dental pain in East delhi children","volume":"2012","author":"Khatri \n A,","year":"2012","unstructured":"Khatri \n A, \n \n \n Kalra \n N. \n \n \n A comparison of two pain scales in the assessment of dental pain in East delhi children. ISRN Dent. 2012;2012:247\u2013351."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/3\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/65\/3\/156\/2103244\/anpr-65-02-08.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/3\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/3\/article-p156.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:41:21Z","timestamp":1728304881000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/3\/article-p156.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2344\/anpr-65-02-08","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"value":"0003-3006","type":"print"},{"value":"1878-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}