{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:49:06Z","timestamp":1792799346160,"version":"4.5.0"},"reference-count":20,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Adverse reactions to local anesthetics are usually a reaction to epinephrine, vasovagal syncope, or overdose toxicity. Allergic reactions to local anesthetics are often attributed to additives such as metabisulfite or methylparaben. True allergic reactions to amide local anesthetics are extremely rare but have been documented. Patients with true allergy to amide local anesthetics present a challenge to the dental practitioner in providing adequate care with appropriate intraoperative pain management. Often, these patients may be treated under general anesthesia. We report a case of a 43-year-old female patient that presented to NYU Lutheran Medical Center Dental Clinic with a documented history of allergy to amide local anesthetics. This case report reviews the use of 1% diphenhydramine with 1:100,000 epinephrine as an alternative local anesthetic and reviews the relevant literature.<\/jats:p>","DOI":"10.2344\/anpr-65-03-06","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T15:56:47Z","timestamp":1530201407000},"page":"119-123","source":"Crossref","is-referenced-by-count":65,"title":["True Allergy to Amide Local Anesthetics: A Review and Case Presentation"],"prefix":"10.2344","volume":"65","author":[{"given":"Babak","family":"Bina","sequence":"first","affiliation":[{"name":"Director General Practice Residency, NYU Lutheran, Brooklyn, New York,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot V.","family":"Hersh","sequence":"additional","affiliation":[{"name":"Professor of Oral Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micael","family":"Hilario","sequence":"additional","affiliation":[{"name":"PGY3 Periodontal Chief Resident, NYU Lutheran, Brooklyn, New York, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenia","family":"Alvarez","sequence":"additional","affiliation":[{"name":"PGY3 Periodontal Chief Resident, NYU Lutheran, Brooklyn, New York, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"PGY2 General Practice Chief Resident, NYU Lutheran, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i0003-3006-65-2-119-b01","series-title":"Br Dent J","first-page":"380","article-title":"Adverse reaction to dental local anaesthetic injection\u2014\u201callergy\u201d is not the cause","volume":"189.7","author":"Rood \n              JP.","year":"2000","unstructured":"Rood \n              JP.\n            \n          \n          Adverse reaction to dental local anaesthetic injection\u2014\u201callergy\u201d is not the cause. Br Dent J. 2000; 189.7: 380\u2013384."},{"key":"i0003-3006-65-2-119-b02","series-title":"Compendium","first-page":"374","article-title":"Local anesthetics: a review of their pharmacology and clinical use","volume":"8","author":"Hersh \n              EV.","year":"1987","unstructured":"Hersh \n              EV.\n            \n            \n              Condouris \n              GA.\n            \n          \n          Local anesthetics: a review of their pharmacology and clinical use. 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J Am Dent Assoc. 1986;113:769\u2013770."},{"key":"i0003-3006-65-2-119-b10","series-title":"J Exp Med","first-page":"415","article-title":"Experiments on histamine as the chemical mediator for cutaneous pain","volume":"70","author":"Rosenthal \n              SR.","year":"1939","unstructured":"Rosenthal \n              SR.\n            \n            \n              Minard \n              D.\n            \n          \n          Experiments on histamine as the chemical mediator for cutaneous pain. 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Ann Emerg Med. 1994;23:1284\u20131289."},{"key":"i0003-3006-65-2-119-b14","series-title":"J Trauma","first-page":"354","article-title":"Lidocaine versus diphenhydramine for anesthesia in the repair of minor lacerations","volume":"34","author":"Ernst \n              AA.","year":"1993","unstructured":"Ernst \n              AA.\n            \n            \n              Anand \n              P.\n            \n            \n              Nick \n              T.\n            \n            \n              Wassmuth \n              S.\n            \n          \n          Lidocaine versus diphenhydramine for anesthesia in the repair of minor lacerations. 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J Oral Surg. 1970;28:335\u2013345"}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/2\/article-p119.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/65\/2\/119\/2101346\/anpr-65-03-06.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/2\/article-p119.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/2\/article-p119.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:41:43Z","timestamp":1728304903000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/2\/article-p119.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2344\/anpr-65-03-06","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"value":"0003-3006","type":"print"},{"value":"1878-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}