{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:43:40Z","timestamp":1780397020506,"version":"3.54.1"},"reference-count":20,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Intravenous sedation (IVS) is commonly used to complete dental treatment for uncooperative pediatric patients. Propofol (PRO) is widely used for IVS because of its short context sensitive half-time and amnestic effect. However, administering PRO to patients who have a history of egg anaphylaxis is still somewhat controversial. The evidence that supports the potential risks for allergic reactions following PRO use in patients with egg allergies is limited with some anesthesiologists recommending against its use in these patients. Alternative drug regimens for procedural sedation in this population are therefore desirable. Dexmedetomidine (DEX), a selective \u03b1-2 agonist, has antianxiety and sedative properties and has been widely used not only for procedural sedation with mild inhibitory effects on respiration but also during minor surgeries for its analgesic effect. In this paper, we describe the successful administration of a combination of DEX and low-dose midazolam (MDZ) for sedation in an uncooperative pediatric patient. Both DEX and MDZ have been reported as safe and useful sedatives for dental treatment, and their combination may provide a helpful option for IVS of pediatric patients for whom PRO is not preferred.<\/jats:p>","DOI":"10.2344\/anpr-65-03-14","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T15:56:47Z","timestamp":1530201407000},"page":"124-126","source":"Crossref","is-referenced-by-count":12,"title":["Sedation With a Combination of Dexmedetomidine and Midazolam for Pediatric Dental Surgery"],"prefix":"10.2344","volume":"65","author":[{"given":"Teppei","family":"Sago","sequence":"first","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Shiiba","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eika","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"Tsunakake","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Akitomi","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Chogyoji","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Science of Physical Functions, Division of Dental Anesthesiology, Kyushu Dental University, Kokurakita, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i0003-3006-65-2-124-b01","series-title":"Am J Emerg Med","first-page":"692","article-title":"Propofol versus midazolam for procedural sedation in the emergency department: a study on efficacy and safety","volume":"35","author":"Lameijer \n              H.","year":"2017","unstructured":"Lameijer \n              H.\n            \n            \n              Sikkema \n              YT.\n            \n            \n              Pol \n              A.\n            \n            et al. \n          Propofol versus midazolam for procedural sedation in the emergency department: a study on efficacy and safety. 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Asian Cardiovasc Thorac Ann. 2015;23:802\u2013808."},{"key":"i0003-3006-65-2-124-b10","series-title":"Anesth Prog","first-page":"3","article-title":"Dexmedetomidine sedation with and without midazolam for third molar surgery","volume":"61","author":"Smiley \n              MK.","year":"2014","unstructured":"Smiley \n              MK.\n            \n            \n              Prior \n              SR.\n            \n          \n          Dexmedetomidine sedation with and without midazolam for third molar surgery. 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A systematic review of efficacy and safety","volume":"12","author":"Barends \n              CR.","year":"2017","unstructured":"Barends \n              CR.\n            \n            \n              Absalom \n              A.\n            \n            \n              van Minnen \n              B.\n            \n            \n              Vissink \n              A.\n            \n            \n              Visser \n              A.\n            \n          \n          Dexmedetomidine versus midazolam in procedural sedation. A systematic review of efficacy and safety. 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J Pak Med Assoc. 2017;67:693\u2013697."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/2\/article-p124.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/65\/2\/124\/2101390\/anpr-65-03-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/2\/article-p124.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/65\/2\/article-p124.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:41:47Z","timestamp":1728304907000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/65\/2\/article-p124.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2344\/anpr-65-03-14","relation":{},"ISSN":["0003-3006","1878-7177"],"issn-type":[{"value":"0003-3006","type":"print"},{"value":"1878-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}