{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:16:39Z","timestamp":1760300199156},"reference-count":33,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>This study aims to compare the effect of topical anesthesia against the use of no topical agent on pain of needle penetration and local anesthesia deposition during buccal infiltration in anterior maxilla. In a randomized controlled trial, 100 adult participants were randomly allocated to the benzocaine group (received 20% benzocaine gel) and no benzocaine group (received no topical agent) prior to buccal infiltration in maxillary anterior teeth. A 27-gauge needle was used to deposit 2% lidocaine with 1:100,000 epinephrine. Pain of needle penetration and local anesthesia deposition was recorded separately using an 11-point Numeric Pain Rating Scale. Results showed that although 20% benzocaine significantly reduced pain on needle penetration during buccal infiltration in maxillary anterior teeth, the difference was small and the clinical significance is not clear. Topical anesthetic did not affect pain of local anesthetic deposition.<\/jats:p>","DOI":"10.2344\/anpr-66-01-01","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T16:51:23Z","timestamp":1552927883000},"page":"24-29","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Topical Benzocaine in Maxilla: A Randomized Controlled Trial"],"prefix":"10.2344","volume":"66","author":[{"given":"Nurain","family":"Rehman","sequence":"first","affiliation":[{"name":"Institute of Dentistry, CMH Lahore Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir Riaz","family":"Qazi","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgeon, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-66-1-24-b01","series-title":"J Am Dent Assoc","first-page":"756","article-title":"Four dimensions of fear of dental injections","volume":"128","author":"Milgrom \n              P,","year":"1997","unstructured":"Milgrom \n              P, \n            \n            \n              Coldwell \n              SE, \n            \n            \n              Getz \n              T, \n            \n            \n              Weinstein \n              P, \n            \n            \n              Ramsay \n              DS. \n            \n          \n          Four dimensions of fear of dental injections. J Am Dent Assoc. 1997;128:756\u2013766."},{"key":"i0003-3006-66-1-24-b02","series-title":"J Am Dent Assoc","first-page":"842","article-title":"Origins and characteristics of fear of dentistry","volume":"86","author":"Kleinknecht \n              RA,","year":"1973","unstructured":"Kleinknecht \n              RA, \n            \n            \n              Klepac \n              RK, \n            \n            \n              Alexander \n              LD. \n            \n          \n          Origins and characteristics of fear of dentistry. J Am Dent Assoc. 1973;86:842\u2013848."},{"key":"i0003-3006-66-1-24-b03","series-title":"J Clin Nursing","first-page":"798","article-title":"Pain: a review of three commonly used pain rating scales","volume":"14","author":"Williamson \n              A,","year":"2005","unstructured":"Williamson \n              A, \n            \n            \n              Hoggart \n              B. \n            \n          \n          Pain: a review of three commonly used pain rating scales. J Clin Nursing. 2005;14:798\u2013804."},{"key":"i0003-3006-66-1-24-b04","series-title":"J Anaesthesiol Clin Pharmacol","first-page":"450","article-title":"Topical anesthesia","volume":"31","author":"Kumar \n              M,","year":"2015","unstructured":"Kumar \n              M, \n            \n            \n              Chawla \n              R, \n            \n            \n              Goyal \n              M. \n            \n          \n          Topical anesthesia. J Anaesthesiol Clin Pharmacol. 2015;31:450\u2013456."},{"key":"i0003-3006-66-1-24-b05","series-title":"Anesth Prog","first-page":"159","article-title":"Effectiveness of 20% benzocaine as a topical anesthetic for intraoral injections","volume":"50","author":"Nusstein \n              JM,","year":"2003","unstructured":"Nusstein \n              JM, \n            \n            \n              Beck \n              M. \n            \n          \n          Effectiveness of 20% benzocaine as a topical anesthetic for intraoral injections. Anesth Prog. 2003;50:159\u2013163."},{"key":"i0003-3006-66-1-24-b06","series-title":"Anesth Prog","first-page":"97","article-title":"Clinical effectiveness of lidocaine and benzocaine for topical anesthesia","volume":"46","author":"Rosa \n              AL,","year":"1999","unstructured":"Rosa \n              AL, \n            \n            \n              Sverzut \n              CE, \n            \n            \n              Xavier \n              SP, \n            \n            \n              Lavrador \n              MA. \n            \n          \n          Clinical effectiveness of lidocaine and benzocaine for topical anesthesia. Anesth Prog. 1999;46:97\u201399."},{"key":"i0003-3006-66-1-24-b07","series-title":"Anesth Prog","first-page":"290","article-title":"An analysis of the effectiveness of two topical anesthetics","volume":"37","author":"Rosivack \n              RG,","year":"1990","unstructured":"Rosivack \n              RG, \n            \n            \n              Koenigsberg \n              SR, \n            \n            \n              Maxwell \n              KC. \n            \n          \n          An analysis of the effectiveness of two topical anesthetics. Anesth Prog. 1990;37:290\u2013292."},{"key":"i0003-3006-66-1-24-b08","series-title":"Anesthesia Prog","first-page":"46","article-title":"Efficacy of benzocaine 20% topical anesthetic compared to placebo prior to administration of local anesthesia in the oral cavity: a randomized controlled trial","volume":"62","author":"De Freiras \n              GC,","year":"2015","unstructured":"De Freiras \n              GC, \n            \n            \n              Pozzobon \n              RT, \n            \n            \n              Blaya \n              DS, \n            \n            \n              Moreira \n              CH. \n            \n          \n          Efficacy of benzocaine 20% topical anesthetic compared to placebo prior to administration of local anesthesia in the oral cavity: a randomized controlled trial. Anesthesia Prog. 2015;62:46\u201350."},{"key":"i0003-3006-66-1-24-b09","series-title":"J Endod","first-page":"1553","article-title":"Effect of topical anesthesia on pain during infiltration injection and success of anesthesia for maxillary central incisors","volume":"38","author":"Parirokh \n              M,","year":"2012","unstructured":"Parirokh \n              M, \n            \n            \n              Sadeghi \n              AS, \n            \n            \n              Nakhaee \n              N, \n            \n            \n              Pardakhty \n              A, \n            \n            \n              Abbott \n              PV, \n            \n            \n              Yosefi \n              MH. \n            \n          \n          Effect of topical anesthesia on pain during infiltration injection and success of anesthesia for maxillary central incisors. J Endod. 2012;38:1553\u20131556."},{"key":"i0003-3006-66-1-24-b10","series-title":"J Am Dent Assoc","first-page":"213","article-title":"A double-blind crossover comparison of topical anesthetics","volume":"98","author":"Gill \n              CJ,","year":"1979","unstructured":"Gill \n              CJ, \n            \n            \n              Orr \n              DL\n              2nd. \n            \n          \n          A double-blind crossover comparison of topical anesthetics. J Am Dent Assoc. 1979;98:213\u2013214."},{"key":"i0003-3006-66-1-24-b11","series-title":"Anesth Prog","first-page":"14","article-title":"Efficacy of mandibular topical anesthesia varies with the site of administration","volume":"43","author":"Nakanishi \n              O,","year":"1996","unstructured":"Nakanishi \n              O, \n            \n            \n              Haas \n              D, \n            \n            \n              Ishikawa \n              T, \n            \n            \n              Kameyama \n              S, \n            \n            \n              Nishi \n              M. \n            \n          \n          Efficacy of mandibular topical anesthesia varies with the site of administration. Anesth Prog. 1996;43:14\u201319."},{"key":"i0003-3006-66-1-24-b12","series-title":"Dent Clin North Am","first-page":"759","article-title":"Effective topical anesthetic agents and techniques","volume":"46","author":"Meechan \n              JG.","year":"2002","unstructured":"Meechan \n              JG. \n            \n          \n          Effective topical anesthetic agents and techniques. 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Anesth Prog. 2009;56:36\u201341."},{"key":"i0003-3006-66-1-24-b14","series-title":"J Manip Physiol Ther","first-page":"1","article-title":"Responsiveness of Pain Scales: a comparison of three pain intensity measures in chiropractic patients","volume":"21","author":"Bolton \n              JE,","year":"1998","unstructured":"Bolton \n              JE, \n            \n            \n              Wilkinson \n              RC. \n            \n          \n          Responsiveness of Pain Scales: a comparison of three pain intensity measures in chiropractic patients. J Manip Physiol Ther. 1998;21:1\u20137."},{"key":"i0003-3006-66-1-24-b15","series-title":"Handbook of Local Anaesthesia. 5th ed","author":"Malamed \n              SF.","year":"2004","unstructured":"Malamed \n              SF. \n            \n          \n          Handbook of Local Anaesthesia. 5th ed. 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Anesth Prog. 1994;41:40\u201347."},{"key":"i0003-3006-66-1-24-b17","series-title":"Pain Pract","first-page":"4","article-title":"Placebo theory and its implications for research and clinical practice: a review of the recent literature","volume":"7","author":"Koshi \n              EB,","year":"2007","unstructured":"Koshi \n              EB, \n            \n            \n              Short \n              CA. \n            \n          \n          Placebo theory and its implications for research and clinical practice: a review of the recent literature. Pain Pract. 2007;7:4\u201320."},{"key":"i0003-3006-66-1-24-b18","series-title":"Gend Med","first-page":"137","article-title":"Sex differences in pain perception","volume":"2","author":"Wiesenfeld \n              HZ.","year":"2005","unstructured":"Wiesenfeld \n              HZ. \n            \n          \n          Sex differences in pain perception. 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Eur J Pain. 2004;8:427\u2013433."},{"key":"i0003-3006-66-1-24-b22","series-title":"Community Dent Oral Epidemiol","first-page":"264","article-title":"Dental fear and pain: effect on patient's perception of the dentist","volume":"18","author":"Kunzelmann \n              KH,","year":"1990","unstructured":"Kunzelmann \n              KH, \n            \n            \n              D\u00fcnninger \n              P. \n            \n          \n          Dental fear and pain: effect on patient's perception of the dentist. Community Dent Oral Epidemiol. 1990;18:264\u2013266."},{"key":"i0003-3006-66-1-24-b23","series-title":"Acta Stomatol Croat","first-page":"258","article-title":"The level of anxiety and pain perception of endodontic patients","volume":"48","author":"Ivana \n              P,","year":"2014","unstructured":"Ivana \n              P, \n            \n            \n              Martina \n              KR, \n            \n            \n              Marina \n              P, \n            \n            \n              Silvana \n              JK. \n            \n          \n          The level of anxiety and pain perception of endodontic patients. Acta Stomatol Croat. 2014;48:258\u2013267."},{"key":"i0003-3006-66-1-24-b24","series-title":"Pediatr Dent","first-page":"265","article-title":"A survey of local and topical anesthesia use by pediatric dentists in the United States","volume":"23","author":"Kohli \n              K,","year":"2001","unstructured":"Kohli \n              K, \n            \n            \n              Ngan \n              P, \n            \n            \n              Crout \n              R, \n            \n            \n              Linscott \n              CC. \n            \n          \n          A survey of local and topical anesthesia use by pediatric dentists in the United States. 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Anesth Prog. 1997;44:87\u201389."},{"key":"i0003-3006-66-1-24-b26","series-title":"Int J Dent Clin","first-page":"11","article-title":"Topical anaesthetic: how effective are they","volume":"3","author":"Dhawan \n              P,","year":"2011","unstructured":"Dhawan \n              P, \n            \n            \n              Dhawan \n              G. \n            \n          \n          Topical anaesthetic: how effective are they. Int J Dent Clin. 2011;3:11\u201313."},{"key":"i0003-3006-66-1-24-b27","series-title":"JAMDSR","first-page":"9","article-title":"Diminution of pain from needle insertion in palatal mucosa by two topical anaesthetics: a comparative study between lidocaine\/prilocaine (EMLA) and benzocaine","volume":"3","author":"Saurabh \n              S,","year":"2015","unstructured":"Saurabh \n              S, \n            \n            \n              Basavapatanna \n              SJ, \n            \n            \n              Khushboo \n              G. \n            \n          \n          Diminution of pain from needle insertion in palatal mucosa by two topical anaesthetics: a comparative study between lidocaine\/prilocaine (EMLA) and benzocaine. JAMDSR. 2015;3:9\u201315."},{"key":"i0003-3006-66-1-24-b28","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"157","article-title":"Comparison of topical anesthesia of 20% benzocaine and 60% lidocaine gel","volume":"94","author":"Fukayama \n              H,","year":"2002","unstructured":"Fukayama \n              H, \n            \n            \n              Suzuki \n              N, \n            \n            \n              Umino \n              M. \n            \n          \n          Comparison of topical anesthesia of 20% benzocaine and 60% lidocaine gel. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:157\u2013161."},{"key":"i0003-3006-66-1-24-b29","series-title":"J Contemp Dent Pract","first-page":"592","article-title":"Effect of topical anesthesia with lidocaine-prilocaine (EMLA) cream and local pressure on pain during infiltration injection for maxillary canines: a randomized double-blind clinical trial","volume":"17","author":"Milani \n              AS,","year":"2016","unstructured":"Milani \n              AS, \n            \n            \n              Zand \n              V, \n            \n            \n              Abdollahi \n              AA, \n            \n            \n              Froughreyhani \n              M, \n            \n            \n              Zakeri-Milani \n              P, \n            \n            \n              Jafarabadi \n              MA. \n            \n          \n          Effect of topical anesthesia with lidocaine-prilocaine (EMLA) cream and local pressure on pain during infiltration injection for maxillary canines: a randomized double-blind clinical trial. J Contemp Dent Pract. 2016;17:592\u2013596."},{"key":"i0003-3006-66-1-24-b30","series-title":"Indian J Dent Res","first-page":"155","article-title":"Evaluation of three topical anaesthetic agents against pain: a clinical study","volume":"17","author":"Nayak \n              R,","year":"2006","unstructured":"Nayak \n              R, \n            \n            \n              Sudha \n              P. \n            \n          \n          Evaluation of three topical anaesthetic agents against pain: a clinical study. 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J Am Dent Assoc. 2001;132:1714\u20131719."},{"key":"i0003-3006-66-1-24-b32","series-title":"Quintessence Int","first-page":"311","article-title":"Psychophysical measurement on pain perception after administration of a topical anesthetic","volume":"22","author":"Kincheloe \n              JE,","year":"1991","unstructured":"Kincheloe \n              JE, \n            \n            \n              Mealiea \n              WL\n              Jr, \n            \n            \n              Mattison \n              GD, \n            \n            \n              Seib \n              K. \n            \n          \n          Psychophysical measurement on pain perception after administration of a topical anesthetic. 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