{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:45:28Z","timestamp":1793324728957,"version":"4.5.0"},"reference-count":13,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"We performed general anesthesia on a 3-year-old boy with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with G6PD deficiency exhibit jaundice and anemia due to hemolysis caused by a lack of the G6PD enzyme. To maintain anesthesia, we used propofol and remifentanil, which may prevent hemolytic attacks by exerting an antioxidant effect. In addition, because the patient was in a high-risk group for the development of methemoglobinemia, we used mepivacaine as a local anesthetic. We liaised with the patient's attending physician to make sufficient arrangements, such as securing an emergency transfer on the day of anesthesia. The patient did not develop hemolytic attacks during or after the procedure, and he progressed well without problems.<\/jats:p>","DOI":"10.2344\/anpr-66-01-05","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T17:29:06Z","timestamp":1560274146000},"page":"94-96","source":"Crossref","is-referenced-by-count":11,"title":["General Anesthesia in a Glucose-6-Phosphate Dehydrogenase Deficiency Child: A Case Report"],"prefix":"10.2344","volume":"66","author":[{"given":"Takahiro","family":"Goi","sequence":"first","affiliation":[{"name":"Department of Dental Anesthesia, Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Shionoya","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Nippon Dental University School of Life Dentistry, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminari","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesia, Nippon Dental University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i0003-3006-66-2-94-b01","series-title":"Anaesthesia","first-page":"281","article-title":"Anaesthesia and glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature","volume":"42","author":"Smith \n CL,","year":"1987","unstructured":"Smith \n CL, \n \n \n Snowdon \n SL. \n \n \n Anaesthesia and glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature. 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Blood. 1985;66:294\u2013297."},{"key":"i0003-3006-66-2-94-b04","series-title":"Hong Kong Med J","first-page":"149","article-title":"Acute massive haemolysis in children with glucose-6-phosphate dehydrogenase deficiency","volume":"12","author":"Lau \n HK,","year":"2006","unstructured":"Lau \n HK, \n \n \n Li \n CH, \n \n \n Lee \n AC. \n \n \n Acute massive haemolysis in children with glucose-6-phosphate dehydrogenase deficiency. Hong Kong Med J. 2006;12:149\u2013151."},{"key":"i0003-3006-66-2-94-b05","series-title":"Xenobiotica","first-page":"431","article-title":"Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine","volume":"47","author":"Hartman \n N,","year":"2017","unstructured":"Hartman \n N, \n \n \n Zhou \n H, \n \n \n Mao \n J, \n \n et al. \n Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. 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N Engl J Med. 1991;324:169\u2013174."},{"key":"i0003-3006-66-2-94-b10","series-title":"Intern Med","first-page":"860","article-title":"Methemoglobinemia induced by combined use of sodium nitrate and acetaminophen","volume":"39","author":"Kobayashi \n T.","year":"2000","unstructured":"Kobayashi \n T. \n \n \n Methemoglobinemia induced by combined use of sodium nitrate and acetaminophen. Intern Med. 2000;39:860."},{"key":"i0003-3006-66-2-94-b11","series-title":"J Pediatr","first-page":"1023","article-title":"Potential risks of hemolysis after short-term administration of analgesics in children with glucose-6-phosphate dehydrogenase deficiency","volume":"159","author":"Najafi \n N,","year":"2011","unstructured":"Najafi \n N, \n \n \n Van de Velde \n A, \n \n \n Poelaert \n J. \n \n \n Potential risks of hemolysis after short-term administration of analgesics in children with glucose-6-phosphate dehydrogenase deficiency. 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