{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:28:15Z","timestamp":1778966895264,"version":"3.51.4"},"reference-count":21,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Lithium carbonate is a medication used for the management of various mental disorders. The present report describes a case of prolongation of rocuronium bromide in a patient concurrently taking lithium carbonate. A 64-year-old woman was scheduled to undergo cystectomy under general anesthesia. The patient took lithium carbonate (600 mg\/d) for treatment of bipolar affective disorder. General anesthesia was induced with propofol, fentanyl, remifentanil, and sevoflurane. After loss of consciousness, rocuronium bromide (50 mg) was administered, and the trachea was intubated. Approximately 1 hour after the administration of rocuronium, the degree of residual muscle relaxant was evaluated using a nerve stimulation device. No muscle contraction occurred with train-of-four (TOF) stimulation. Following administration of sugammadex (200 mg) the TOF ratio increased to 95%. The ionic size of lithium is similar to that of sodium; therefore, lithium is transported into the cell with sodium. The resting membrane potential decreases, leading to a reduction in the height of the action potential. Thus, the effect of the remaining lithium may have been superimposed on the rocuronium neuromuscular blockade. Evaluation with a nerve stimulation device in patients taking lithium is crucial before extubation because of the risk of rocuronium potentiation.<\/jats:p>","DOI":"10.2344\/anpr-66-04-04","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T20:40:14Z","timestamp":1601412014000},"page":"146-150","source":"Crossref","is-referenced-by-count":7,"title":["Potentiation of Rocuronium Bromide by Lithium Carbonate: A Case Report"],"prefix":"10.2344","volume":"67","author":[{"given":"Naotaka","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Division of Dental Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Dental Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-67-3-146-b01","series-title":"Int J Obstet Anesth","first-page":"164","article-title":"Lithium toxicity and the parturient: case report and literature review","volume":"17","author":"Blake","year":"2008","unstructured":"Blake\n              LD,\n            \n            \n              Lucas\n              DN,\n            \n            \n              Aziz\n              K,\n            \n            \n              Castello-Cortes\n              A,\n            \n            \n              Robinson\n              PN.\n            \n          \n          Lithium toxicity and the parturient: case report and literature review.\n\t\t\t\t\tInt J Obstet Anesth.\n\t\t\t\t\t2008;17:164\u2013169."},{"key":"i0003-3006-67-3-146-b02","series-title":"Anesth Prog","first-page":"138","article-title":"Anesthetic management of lithium-treated patients","volume":"31","author":"Leone","year":"1984","unstructured":"Leone\n              CW.\n            \n          \n          Anesthetic management of lithium-treated patients.\n\t\t\t\t\tAnesth Prog.\n\t\t\t\t\t1984;31:138\u2013140."},{"key":"i0003-3006-67-3-146-b03","series-title":"Anesthesiology","first-page":"439","article-title":"Potentiation of succinylcholine neuromuscular blockade by lithium carbonate","volume":"44","author":"Hill","year":"1976","unstructured":"Hill\n              GE,\n            \n            \n              Wong\n              KC,\n            \n            \n              Hodges\n              MR.\n            \n          \n          Potentiation of succinylcholine neuromuscular blockade by lithium carbonate.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t1976;44:439\u2013442."},{"key":"i0003-3006-67-3-146-b04","series-title":"Eur J Pharmacol","first-page":"79","article-title":"Potentiation of d-tubocurarine (d-Tc) neuromuscular blockade in cats by lithium chloride","volume":"45","author":"Basuray","year":"1977","unstructured":"Basuray\n              BN,\n            \n            \n              Harris\n              CA.\n            \n          \n          Potentiation of d-tubocurarine (d-Tc) neuromuscular blockade in cats by lithium chloride.\n\t\t\t\t\tEur J Pharmacol.\n\t\t\t\t\t1977;45:79\u201382."},{"key":"i0003-3006-67-3-146-b05","series-title":"Can Anaesth Soc J","first-page":"79","article-title":"The use of pancuronium bromide in patients receiving lithium carbonate","volume":"21","author":"Borden","year":"1974","unstructured":"Borden\n              H,\n            \n            \n              Clarke\n              MT,\n            \n            \n              Katz\n              H.\n            \n          \n          The use of pancuronium bromide in patients receiving lithium carbonate.\n\t\t\t\t\tCan Anaesth Soc J.\n\t\t\t\t\t1974;21:79\u201382."},{"key":"i0003-3006-67-3-146-b06","series-title":"Miller's Anesthesia","first-page":"1604","article-title":"Neuromuscular monitoring","author":"Viby-Mogensen","year":"2015","unstructured":"Viby-Mogensen\n              J,\n            \n            \n              Claudius\n              C.\n            \n          \n          Neuromuscular monitoring.\n\t\t\t\t\tIn:MillerRD,ed.Miller's Anesthesia.\n\t\t\t\t\t8th ed. 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failure","volume":"48","author":"Khuenl-Brady","year":"1993","unstructured":"Khuenl-Brady\n              KS,\n            \n            \n              Pomaroli\n              A,\n            \n            \n              P\u00fchringer\n              F,\n            \n            \n              Mitterschiffthaler\n              G,\n            \n            \n              Koller\n              J.\n            \n          \n          The use of rocuronium (ORG 9426) in patients with chronic renal failure.\n\t\t\t\t\tAnaesthesia.\n\t\t\t\t\t1993;48:873\u2013875."},{"key":"i0003-3006-67-3-146-b17","series-title":"Acta Anaesthesiol Scand","first-page":"236","article-title":"The effects of age on maintenance of intense neuromuscular block with rocuronium","volume":"56","author":"Furuya","year":"2012","unstructured":"Furuya\n              T,\n            \n            \n              Suzuki\n              T,\n            \n            \n              Kashiwai\n              A,\n           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         \n          \n          Sugammadex: a review of neuromuscular blockade reversal.\n\t\t\t\t\tDrugs.\n\t\t\t\t\t2016;76:1041\u20131052."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/67\/3\/article-p146.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/67\/3\/146\/2598051\/i0003-3006-67-3-146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/67\/3\/article-p146.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/67\/3\/article-p146.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:42:49Z","timestamp":1728304969000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/67\/3\/article-p146.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":21,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2344\/anpr-66-04-04","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}