{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:16:18Z","timestamp":1790615778661,"version":"4.1.0"},"reference-count":19,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p>There are numerous causes of cardiac arrest in the perioperative period, including hypoxia, hypovolemia, and vagal response to medications or procedures during routine anesthetics. Initiation of adequate cardiopulmonary resuscitation, administration of epinephrine, and application of a defibrillator, with shocking when applicable, are all essential steps in achieving return of spontaneous circulation. Knowledge and utilization of monitoring equipment can alert the provider to problems leading to cardiac arrest as well as ensure proper resuscitative efforts during the event. Polypharmacy is quite common with many of today's special needs patients. It is important to understand the medications they are taking as well as the potential interactions that may occur with drugs given during sedation and general anesthesia. The following is a case report of cardiac arrest including asystole and pulseless electrical activity in a 27-year-old man with autism and behavioral problems who presented for restorative dentistry under general anesthesia in the ambulatory surgery setting.<\/jats:p>","DOI":"10.2344\/anpr-67-03-08","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T20:13:52Z","timestamp":1617826432000},"page":"38-44","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac Arrest Upon Induction of General Anesthesia"],"prefix":"10.2344","volume":"68","author":[{"given":"Regina A. E.","family":"Dowdy","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery and Dental Anesthesiology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadee. T.","family":"Mansour","sequence":"additional","affiliation":[{"name":"College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Cottle","sequence":"additional","affiliation":[{"name":"College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Mabe","sequence":"additional","affiliation":[{"name":"College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry B.","family":"Weprin","sequence":"additional","affiliation":[{"name":"College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh E.","family":"Yarborough","sequence":"additional","affiliation":[{"name":"College of Dentistry, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Ness","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery and Dental Anesthesiology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery and Dental Anesthesiology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryant W.","family":"Cornelius","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery and Dental Anesthesiology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2021041916280839600_i0003-3006-68-1-38-b01","doi-asserted-by":"crossref","unstructured":"Moitra\n              VK,\n            \n            \n              Einav\n              S,\n            \n            \n              Thies\n              K,\n            \n            et al.\n\t\t\t\t\t\n          Cardiac arrest in the operating room: resuscitation and management for the anesthesiologist: part 1.\n\t\t\t\t\tAnesth Anal.\n\t\t\t\t\t2018;\n\t\t\t\t\t126:\n\t\t\t\t\t876\u2013\n\t\t\t\t\t888.","DOI":"10.1213\/ANE.0000000000002596"},{"key":"2021041916280839600_i0003-3006-68-1-38-b02","unstructured":"Albert\n              CM,\n            \n            \n              Stevenson\n              WG.\n            \n          \n          Cardiovascular collapse, cardiac arrest, and sudden cardiac death.\n\t\t\t\t\tIn:JamesonJ,FauciAS,DL,KasperHauserSL,LongoDL,LoscalzoJ,eds.Harrison's Principles of Internal Medicine. 20th ed.\n\t\t\t\t\tNew York, NY:\n\t\t\t\t\tMcGraw-Hill.\n\t\t\t\t\tAvailable at: http:\/\/accessmedicine.mhmedical.com.proxy.lib.ohio-state.edu\/content.aspx?bookid=2129&sectionid=192032247."},{"key":"2021041916280839600_i0003-3006-68-1-38-b03","unstructured":"Sinz\n              E,\n            \n            \n              Navarro\n              K,\n            \n            \n              Soderberg\n              ES,\n            \n            \n              Callaway\n              CW.\n            \n          \n          \n            Advanced Cardiovascular Life Support\n          .\n\t\t\t\t\tDallas, TX:\n\t\t\t\t\tAmerican Heart Association;2011."},{"key":"2021041916280839600_i0003-3006-68-1-38-b04","doi-asserted-by":"crossref","unstructured":"Eisenberg\n              MS,\n            \n            \n              Mengert\n              TJ.\n            \n          \n          Cardiac resuscitation.\n\t\t\t\t\tN Engl J Medi.\n\t\t\t\t\t2001;\n\t\t\t\t\t344:\n\t\t\t\t\t1304\u2013\n\t\t\t\t\t1313.","DOI":"10.1056\/NEJM200104263441707"},{"key":"2021041916280839600_i0003-3006-68-1-38-b05","doi-asserted-by":"crossref","unstructured":"Giovannitti\n              JA,\n            \n            \n              Thoms\n              SM,\n            \n            \n              Crawford\n              JJ.\n            \n          \n          Alpha-2 adrenergic receptor agonists: a review of current clinical applications.\n\t\t\t\t\tAnesth Prog.\n\t\t\t\t\t2015;\n\t\t\t\t\t62:\n\t\t\t\t\t31\u2013\n\t\t\t\t\t39.","DOI":"10.2344\/0003-3006-62.1.31"},{"key":"2021041916280839600_i0003-3006-68-1-38-b06","unstructured":"Westfall\n              TC,\n            \n            \n              Macarthur\n              H,\n            \n            \n              Westfall\n              DP.\n            \n          \n          Neurotransmission: the autonomic and somatic motor nervous systems.\n\t\t\t\t\tIn:BruntonLL,Hilal-DandanR,KnollmannBC,eds.Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13th ed.\n\t\t\t\t\tNew York, NY:\n\t\t\t\t\tMcGraw-Hill.\n\t\t\t\t\tAvailable at: http:\/\/accessmedicine.mhmedical.com.proxy.lib.ohio-state.edu\/content.aspx?bookid=2189&sectionid=172473947."},{"key":"2021041916280839600_i0003-3006-68-1-38-b07","doi-asserted-by":"crossref","unstructured":"Hersh\n              EV,\n            \n            \n              Giannakopoulos\n              H.\n            \n          \n          Beta-adrenergic blocking agents and dental vasoconstrictors.\n\t\t\t\t\tDent Clin North Am.\n\t\t\t\t\t2010;\n\t\t\t\t\t54:\n\t\t\t\t\t687\u2013\n\t\t\t\t\t696.","DOI":"10.1016\/j.cden.2010.06.009"},{"key":"2021041916280839600_i0003-3006-68-1-38-b08","doi-asserted-by":"crossref","unstructured":"Merck\n              S.\n            \n          \n          Adverse effects of epinephrine when given to patients taking propranolol (Inderal).\n\t\t\t\t\tJ Emerg Nurs.\n\t\t\t\t\t1995;\n\t\t\t\t\t21:\n\t\t\t\t\t27\u2013\n\t\t\t\t\t32.","DOI":"10.1016\/S0099-1767(95)80008-5"},{"key":"2021041916280839600_i0003-3006-68-1-38-b09","unstructured":"Hersh\n              EV,\n            \n            \n              Moore\n              PA.\n            \n          \n          Three serious drug interactions that every dentist should know about.\n\t\t\t\t\tCompend Contin Educ Dent.\n\t\t\t\t\t2015;\n\t\t\t\t\t36:\n\t\t\t\t\t408\u2013\n\t\t\t\t\t414."},{"key":"2021041916280839600_i0003-3006-68-1-38-b10","unstructured":"Westfall\n              TC,\n            \n            \n              Macarthur\n              H,\n            \n            \n              Westfall\n              DP.\n            \n          \n          Adrenergic agonists and antagonists.\n\t\t\t\t\tIn:BruntonLL,Hilal-DandanR,KnollmannBC,eds.Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 13th ed.\n\t\t\t\t\tNew York, NY:\n\t\t\t\t\tMcGraw-Hill.\n\t\t\t\t\tAvailable at: http:\/\/accessmedicine.mhmedical.com.proxy.lib.ohio-state.edu\/content.aspx?bookid=2189&sectionid=167890123."},{"key":"2021041916280839600_i0003-3006-68-1-38-b11","unstructured":"Intuniv (Guanfacine) Extended-Release Tablets\n          .\n\t\t\t\t\tWayne, PA:\n\t\t\t\t\tShire Pharmaceuticals;\n\t\t\t\t\t2011."},{"key":"2021041916280839600_i0003-3006-68-1-38-b12","doi-asserted-by":"crossref","unstructured":"Walton\n              J,\n            \n            \n              Byrum\n              M,\n            \n            \n              Shumaker\n              A,\n            \n            \n              Coury\n              DL.\n            \n          \n          Prolonged bradycardia and hypotension following guanfacine extended release overdose.\n\t\t\t\t\tJ Child Adolesc Psychopharmacol.\n\t\t\t\t\t2014;\n\t\t\t\t\t24:\n\t\t\t\t\t463\u2013\n\t\t\t\t\t465.","DOI":"10.1089\/cap.2014.0022"},{"key":"2021041916280839600_i0003-3006-68-1-38-b13","doi-asserted-by":"crossref","unstructured":"Fein\n              DM,\n            \n            \n              Hafeez\n              ZF,\n            \n            \n              Cavagnaro\n              C.\n            \n          \n          An overdose of extended-release guanfacine.\n\t\t\t\t\tPediatr Emerg Care.\n\t\t\t\t\t2013;\n\t\t\t\t\t29:\n\t\t\t\t\t929\u2013\n\t\t\t\t\t931.","DOI":"10.1097\/PEC.0b013e31829ec525"},{"key":"2021041916280839600_i0003-3006-68-1-38-b14","doi-asserted-by":"crossref","unstructured":"Roerig\n              DL,\n            \n            \n              Kotrly\n              KJ,\n            \n            \n              Ahlf\n              SB,\n            \n            \n              Dawson\n              CA,\n            \n            \n              Kampine\n              JP.\n            \n          \n          Effect of propranolol on the first pass uptake of fentanyl in the human and rat lung.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t1989;\n\t\t\t\t\t71:\n\t\t\t\t\t62\u2013\n\t\t\t\t\t68.","DOI":"10.1097\/00000542-198907000-00012"},{"key":"2021041916280839600_i0003-3006-68-1-38-b15","doi-asserted-by":"crossref","unstructured":"Taeger\n              K,\n            \n            \n              Weninger\n              E,\n            \n            \n              Franke\n              M,\n            \n            \n              Finsterer\n              U.\n            \n          \n          Uptake of fentanyl by the human lung.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t1984;\n\t\t\t\t\t61:\n\t\t\t\t\tA246.","DOI":"10.1097\/00000542-198409001-00246"},{"key":"2021041916280839600_i0003-3006-68-1-38-b16","doi-asserted-by":"crossref","unstructured":"Russ\n              MJ,\n            \n            \n              Bailine\n              SH.\n            \n          \n          Asystole and bradycardia related to anesthetic induction during ECT: a case report.\n\t\t\t\t\tJ ECT.\n\t\t\t\t\t2004;\n\t\t\t\t\t20:\n\t\t\t\t\t195\u2013\n\t\t\t\t\t197.","DOI":"10.1097\/00124509-200409000-00012"},{"key":"2021041916280839600_i0003-3006-68-1-38-b17","doi-asserted-by":"crossref","unstructured":"Inoue\n              K,\n            \n            \n              Reichelt\n              W.\n            \n          \n          Asystole and bradycardia in adult patients after a single dose of suxamethonium.\n\t\t\t\t\tActa Anaesthesiol Scand.\n\t\t\t\t\t1986;\n\t\t\t\t\t30:\n\t\t\t\t\t571\u2013\n\t\t\t\t\t573.","DOI":"10.1111\/j.1399-6576.1986.tb02477.x"},{"key":"2021041916280839600_i0003-3006-68-1-38-b18","doi-asserted-by":"crossref","unstructured":"Egan\n              TD,\n            \n            \n              Brock-Utne\n              JG.\n            \n          \n          Asystole after anesthesia induction with a fentanyl, propofol, and succinylcholine sequence.\n\t\t\t\t\tAnesthes Analg.\n\t\t\t\t\t1991;\n\t\t\t\t\t73:\n\t\t\t\t\t818\u2013\n\t\t\t\t\t820.","DOI":"10.1213\/00000539-199112000-00025"},{"key":"2021041916280839600_i0003-3006-68-1-38-b19","doi-asserted-by":"crossref","unstructured":"McLeskey\n              CH,\n            \n            \n              McLeod\n              DS,\n            \n            \n              Hough\n              TL,\n            \n            \n              Stallworth\n              JM.\n            \n          \n          Prolonged asystole after succinylcholine administration.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t1978;\n\t\t\t\t\t49:\n\t\t\t\t\t208\u2013\n\t\t\t\t\t209.","DOI":"10.1097\/00000542-197809000-00012"}],"container-title":["Anesthesia Progress"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/68\/1\/38\/2812636\/i0003-3006-68-1-38.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/68\/1\/38\/2812636\/i0003-3006-68-1-38.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:51:15Z","timestamp":1705589475000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/68\/1\/article-p38.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,7]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.2344\/anpr-67-03-08","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}