{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:16:22Z","timestamp":1728360982187},"reference-count":20,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>The objectives of this research were to investigate (a) what was the most effective infusion rate of remifentanil and (b) the degree to which sympathomimetic effects were involved with cardiovascular stimulation by using a power spectral analysis of heart rate variability (HRV). A total of 63 healthy individuals scheduled for sagittal split ramus osteotomy were enrolled and randomly allocated to 1 of 3 groups: remifentanil infusion rate of 0.1, 0.2, or 0.4 \u03bcg\/kg\/min. Anesthesia was maintained with remifentanil and propofol. Before the surgical procedure, 2% lidocaine containing 12.5 \u03bcg\/mL epinephrine was administered in the surgical field for local anesthesia. Systolic blood pressure (SBP), heart rate (HR), low-frequency (LF) and high-frequency (HF) components in HRV power spectral analysis, and the LF\/HF ratio were analyzed. Increases in SBP and HR were observed after local anesthesia in all 3 groups, but no significant differences were observed between the groups. Remifentanil infusion at 0.1 \u03bcg\/kg\/min may be appropriate to minimize cardiovascular stimulation caused by exogenous epinephrine from local anesthesia. Although a rise in the LF\/HF ratio was observed after local anesthesia in all groups, no relationship was observed between the cardiovascular changes and the increase in LF\/HF ratio. This suggests that sympathomimetic effects are involved to a lesser extent with the cardiovascular stimulation caused by exogenous epinephrine.<\/jats:p>","DOI":"10.2344\/anpr-67-03-10","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:11:52Z","timestamp":1617840712000},"page":"10-18","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Remifentanil on Cardiovascular Stimulation Caused by Local Anesthetic With Epinephrine: A Power Spectral Analysis"],"prefix":"10.2344","volume":"68","author":[{"given":"Asako","family":"Eriguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Associate Professor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Koukita","sequence":"additional","affiliation":[{"name":"Visiting Professor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i0003-3006-68-1-10-b01","series-title":"J Dent Anesth Pain Med","first-page":"143","article-title":"Comparative evaluation of the efficacy, safety, and hemostatic effect of 2% lidocaine with various concentrations of epinephrine","volume":"18","author":"Karm","year":"2018","unstructured":"Karm\n              MH,\n            \n            \n              Kim\n              M,\n            \n            \n              Park\n              FD,\n            \n            et al.\n\t\t\t\t\t\n          Comparative evaluation of the efficacy, safety, and hemostatic effect of 2% lidocaine with various concentrations of epinephrine.\n\t\t\t\t\tJ Dent Anesth Pain Med.\n\t\t\t\t\t2018;\n\t\t\t\t\t18:\n\t\t\t\t\t143\u2013\n\t\t\t\t\t146."},{"key":"i0003-3006-68-1-10-b02","series-title":"J Hypertens","first-page":"747","article-title":"Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma","volume":"7","author":"Persson","year":"1989","unstructured":"Persson\n              B,\n            \n            \n              Andersson\n              OK,\n            \n            \n              Hjemdahl\n              P,\n            \n            et al.\n\t\t\t\t\t\n          Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma.\n\t\t\t\t\tJ Hypertens.\n\t\t\t\t\t1989;\n\t\t\t\t\t7:\n\t\t\t\t\t747\u2013\n\t\t\t\t\t756."},{"key":"i0003-3006-68-1-10-b03","series-title":"Eur J Pharmacol","first-page":"75","article-title":"Increased noradrenaline release in rat portal vein during sympathetic nerve stimulation due to activation of presynaptic beta-adrenoceptors by noradrenaline and adrenaline","volume":"1","author":"Dahl\u00f6f","year":"1978","unstructured":"Dahl\u00f6f\n              C,\n            \n            \n              Ljung\n              B,\n            \n            \n              Ablad\n              B.\n            \n          \n          Increased noradrenaline release in rat portal vein during sympathetic nerve stimulation due to activation of presynaptic beta-adrenoceptors by noradrenaline and adrenaline.\n\t\t\t\t\tEur J Pharmacol.\n\t\t\t\t\t1978;\n\t\t\t\t\t1:\n\t\t\t\t\t75\u2013\n\t\t\t\t\t78."},{"key":"i0003-3006-68-1-10-b04","series-title":"J Pak Med Assoc","first-page":"1088","article-title":"Effect on blood pressure and pulse rate after administration of an epinephrine containing dental local anaesthetic in hypertensive patients","volume":"61","author":"Chaudhry","year":"2011","unstructured":"Chaudhry\n              S,\n            \n            \n              Iqbal\n              HA,\n            \n            \n              Izhar\n              F,\n            \n            et al.\n\t\t\t\t\t\n          Effect on blood pressure and pulse rate after administration of an epinephrine containing dental local anaesthetic in hypertensive patients.\n\t\t\t\t\tJ Pak Med Assoc.\n\t\t\t\t\t2011;\n\t\t\t\t\t61:\n\t\t\t\t\t1088\u2013\n\t\t\t\t\t1091."},{"key":"i0003-3006-68-1-10-b05","series-title":"Anaesthesia","first-page":"307","article-title":"A comparison of remifentanil and alfentanil in patients undergoing major abdominal surgery","volume":"52","author":"Sch\u00fcttler","year":"1997","unstructured":"Sch\u00fcttler\n              J,\n            \n            \n              Albrecht\n              S,\n            \n            \n              Breivik\n              H,\n            \n            et al.\n\t\t\t\t\t\n          A comparison of remifentanil and alfentanil in patients undergoing major abdominal surgery.\n\t\t\t\t\tAnaesthesia.\n\t\t\t\t\t1997;\n\t\t\t\t\t52:\n\t\t\t\t\t307\u2013\n\t\t\t\t\t317."},{"key":"i0003-3006-68-1-10-b06","series-title":"Textbook of Intravenous Anesthesia","first-page":"213","article-title":"Fentanyl and its congeners","author":"Bailey","year":"1997","unstructured":"Bailey\n              P,\n            \n            \n              Egan\n              TD.\n            \n          \n          Fentanyl and its congeners.\n\t\t\t\t\tIn:BaileyP,EganTD,eds.Textbook of Intravenous Anesthesia.\n\t\t\t\t\tBaltimore, MD:\n\t\t\t\t\tWilliams & Wilkins;1997:\n\t\t\t\t\t213\u2013\n\t\t\t\t\t246."},{"key":"i0003-3006-68-1-10-b07","series-title":"Anesth Analg","first-page":"279","article-title":"A multicenter evaluation of total intravenous anesthesia with remifentanil and propofol for elective inpatient surgery","volume":"83","author":"Hogue","year":"1996","unstructured":"Hogue\n              CW\n              Jr,\n            \n            \n              Bowdle\n              TA,\n            \n            \n              O'Leary\n              C,\n            \n            et al.\n\t\t\t\t\t\n          A multicenter evaluation of total intravenous anesthesia with remifentanil and propofol for elective inpatient surgery.\n\t\t\t\t\tAnesth Analg.\n\t\t\t\t\t1996;\n\t\t\t\t\t83:\n\t\t\t\t\t279\u2013\n\t\t\t\t\t285."},{"key":"i0003-3006-68-1-10-b08","series-title":"Anesth Prog","first-page":"150","article-title":"Hemodynamic changes by drug interaction of adrenaline with chlorpromazine","volume":"61","author":"Higuchi","year":"2014","unstructured":"Higuchi\n              H,\n            \n            \n              Yabuki\n              A,\n            \n            \n              Ishii-Maruhama\n              M,\n            \n            et al.\n\t\t\t\t\t\n          Hemodynamic changes by drug interaction of adrenaline with chlorpromazine.\n\t\t\t\t\tAnesth Prog.\n\t\t\t\t\t2014;\n\t\t\t\t\t61:\n\t\t\t\t\t150\u2013\n\t\t\t\t\t154."},{"key":"i0003-3006-68-1-10-b09","series-title":"Can J Anaesth","first-page":"20","article-title":"Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty","volume":"48","author":"Degoute","year":"2001","unstructured":"Degoute\n              CS,\n            \n            \n              Ray\n              MJ,\n            \n            \n              Manchon\n              M,\n            \n            et al.\n\t\t\t\t\t\n          Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty.\n\t\t\t\t\tCan J Anaesth.\n\t\t\t\t\t2001:\n\t\t\t\t\t48:\n\t\t\t\t\t20\u2013\n\t\t\t\t\t27."},{"key":"i0003-3006-68-1-10-b10","series-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","first-page":"725","article-title":"The cardiovascular effect of local anesthesia with articaine plus 1:200,000 adrenalin versus lidocaine plus 1:100,000 adrenalin in medically compromised cardiac patients: a prospective, randomized, double blinded study","volume":"105","author":"Elad","year":"2008","unstructured":"Elad\n              S,\n            \n            \n              Admon\n              D,\n            \n            \n              Kedmi\n              M,\n            \n            et al.\n\t\t\t\t\t\n          The cardiovascular effect of local anesthesia with articaine plus 1:200,000 adrenalin versus lidocaine plus 1:100,000 adrenalin in medically compromised cardiac patients: a prospective, randomized, double blinded study.\n\t\t\t\t\tOral Surg Oral Med Oral Pathol Oral Radiol Endod.\n\t\t\t\t\t2008;\n\t\t\t\t\t105:\n\t\t\t\t\t725\u2013\n\t\t\t\t\t730."},{"key":"i0003-3006-68-1-10-b11","series-title":"Science","first-page":"220","article-title":"Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control","volume":"213","author":"Akselrod","year":"1981","unstructured":"Akselrod\n              S,\n            \n            \n              Gordon\n              D,\n            \n            \n              Ubel\n              FA,\n            \n            et al.\n\t\t\t\t\t\n          Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control.\n\t\t\t\t\tScience.\n\t\t\t\t\t1981;\n\t\t\t\t\t213:\n\t\t\t\t\t220\u2013\n\t\t\t\t\t222."},{"key":"i0003-3006-68-1-10-b12","series-title":"Am J Physiol","first-page":"H151","article-title":"Assessment of autonomic function in humans by heart rate spectral analysis","volume":"248","author":"Pomeranz","year":"1985","unstructured":"Pomeranz\n              B,\n            \n            \n              Macaulay\n              RJ,\n            \n            \n              Caudill\n              MA,\n            \n            et al.\n\t\t\t\t\t\n          Assessment of autonomic function in humans by heart rate spectral analysis.\n\t\t\t\t\tAm J Physiol.\n\t\t\t\t\t1985;\n\t\t\t\t\t248:\n\t\t\t\t\tH151\u2013\n\t\t\t\t\tH153."},{"key":"i0003-3006-68-1-10-b13","series-title":"J Oral Maxillofac Surg","first-page":"590","article-title":"Midazolam more effectively suppresses sympathetic activations and reduces stress feelings during mental arithmetic task than propofol","volume":"68","author":"Tsugayasu","year":"2010","unstructured":"Tsugayasu\n              R,\n            \n            \n              Handa\n              T,\n            \n            \n              Kaneko\n              Y,\n            \n            et al.\n\t\t\t\t\t\n          Midazolam more effectively suppresses sympathetic activations and reduces stress feelings during mental arithmetic task than propofol.\n\t\t\t\t\tJ Oral Maxillofac Surg.\n\t\t\t\t\t2010;\n\t\t\t\t\t68:\n\t\t\t\t\t590\u2013\n\t\t\t\t\t596."},{"key":"i0003-3006-68-1-10-b14","series-title":"Anesth Analg","first-page":"415","article-title":"A comparison of propofol and dexmedetomidine for intravenous sedation: a randomized, crossover study of the effects on the central and autonomic nervous systems","volume":"110","author":"Okawa","year":"2010","unstructured":"Okawa\n              K,\n            \n            \n              Ichinohe\n              T,\n            \n            \n              Kaneko\n              Y.\n            \n          \n          A comparison of propofol and dexmedetomidine for intravenous sedation: a randomized, crossover study of the effects on the central and autonomic nervous systems.\n\t\t\t\t\tAnesth Analg.\n\t\t\t\t\t2010;\n\t\t\t\t\t110:\n\t\t\t\t\t415\u2013\n\t\t\t\t\t418."},{"key":"i0003-3006-68-1-10-b15","series-title":"Br J Anaesth","first-page":"150","article-title":"Surgical stress index in response to pacemaker stimulation or atropine","volume":"105","author":"H\u00f6cker","year":"2010","unstructured":"H\u00f6cker\n              J,\n            \n            \n              Broch\n              O,\n            \n            \n              Gr\u00e4sner\n              JT,\n            \n            et al.\n\t\t\t\t\t\n          Surgical stress index in response to pacemaker stimulation or atropine.\n\t\t\t\t\tBr J Anaesth.\n\t\t\t\t\t2010;\n\t\t\t\t\t105:\n\t\t\t\t\t150\u2013\n\t\t\t\t\t154."},{"key":"i0003-3006-68-1-10-b16","series-title":"Anesthesiology","first-page":"345","article-title":"Cardiovascular effects of carbon dioxide in man","volume":"41","author":"Cullen","year":"1974","unstructured":"Cullen\n              DJ,\n            \n            \n              Eger\n              EI.\n            \n          \n          Cardiovascular effects of carbon dioxide in man.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t1974;\n\t\t\t\t\t41:\n\t\t\t\t\t345\u2013\n\t\t\t\t\t349."},{"key":"i0003-3006-68-1-10-b17","series-title":"J Anesth","first-page":"673","article-title":"Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study","volume":"32","author":"Jor","year":"2018","unstructured":"Jor\n              O,\n            \n            \n              Maca\n              J,\n            \n            \n              Koutna\n              J,\n            \n            et al.\n\t\t\t\t\t\n          Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.\n\t\t\t\t\tJ Anesth.\n\t\t\t\t\t2018;\n\t\t\t\t\t32:\n\t\t\t\t\t673\u2013\n\t\t\t\t\t680."},{"key":"i0003-3006-68-1-10-b18","series-title":"Anesthesiology","first-page":"658","article-title":"Intraoperative hypotension and perioperative ischemic stroke after general surgery: a nested case-control study","volume":"116","author":"Bijker","year":"2012","unstructured":"Bijker\n              JB,\n            \n            \n              Persoon\n              S,\n            \n            \n              Peelen\n              LM,\n            \n            et al.\n\t\t\t\t\t\n          Intraoperative hypotension and perioperative ischemic stroke after general surgery: a nested case-control study.\n\t\t\t\t\tAnesthesiology.\n\t\t\t\t\t2012;\n\t\t\t\t\t116:\n\t\t\t\t\t658\u2013\n\t\t\t\t\t664."},{"key":"i0003-3006-68-1-10-b19","series-title":"Anesth Analg","first-page":"97","article-title":"The different effects of intravenous propofol and midazolam sedation on hemodynamic and heart rate variability","volume":"101","author":"Win","year":"2005","unstructured":"Win\n              NN,\n            \n            \n              Fukayama\n              H,\n            \n            \n              Kohase\n              H,\n            \n            et al.\n\t\t\t\t\t\n          The different effects of intravenous propofol and midazolam sedation on hemodynamic and heart rate variability.\n\t\t\t\t\tAnesth Analg.\n\t\t\t\t\t2005;\n\t\t\t\t\t101:\n\t\t\t\t\t97\u2013\n\t\t\t\t\t102."},{"key":"i0003-3006-68-1-10-b20","series-title":"J Oral Maxillofac Surg","first-page":"1714.e1","article-title":"Effects of volatile anesthetics on oral tissue blood flow in rabbits: a comparison among isoflurane, sevoflurane, and desflurane","volume":"73","author":"Okamoto","year":"2015","unstructured":"Okamoto\n              S,\n            \n            \n              Matsuura\n              N,\n            \n            \n              Ichinohe\n              T:\n            \n          \n          Effects of volatile anesthetics on oral tissue blood flow in rabbits: a comparison among isoflurane, sevoflurane, and desflurane.\n\t\t\t\t\tJ Oral Maxillofac Surg.\n\t\t\t\t\t2015;\n\t\t\t\t\t73:\n\t\t\t\t\t1714.e1\u2013\n\t\t\t\t\te8."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/68\/1\/article-p10.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/anesthesia-progress\/article-pdf\/68\/1\/10\/2812608\/i0003-3006-68-1-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/68\/1\/article-p10.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/68\/1\/article-p10.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:44:24Z","timestamp":1728305064000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/68\/1\/article-p10.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2344\/anpr-67-03-10","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"type":"electronic","value":"1878-7177"},{"type":"print","value":"0003-3006"}],"subject":[],"published":{"date-parts":[[2021]]}}}