{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:09:50Z","timestamp":1788995390155,"version":"build-2803163510"},"reference-count":21,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Pseudocholinesterase deficiency, sometimes called butyrylcholinesterase deficiency, is a rare disorder in which the neuromuscular blocking drugs succinylcholine and mivacurium cannot be metabolized properly in the blood plasma. This disorder can either be acquired as a result of certain comorbidities or it can be inherited genetically. Anesthesia providers must understand the pathophysiology of pseudocholinesterase deficiency and be prepared to safely and effectively manage patients who show signs and symptoms consistent with the disorder after the use of the indicated neuromuscular blocking drugs. This article summarizes the pharmacologic and physiologic data relevant to understanding the basic pathophysiology associated with pseudocholinesterase deficiency and illustrates a case study of a young woman suspected of having the disorder after a prolonged delay in emergence from general anesthesia.<\/jats:p>","DOI":"10.2344\/anpr-67-03-16","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T16:47:14Z","timestamp":1601398034000},"page":"177-184","source":"Crossref","is-referenced-by-count":12,"title":["Pseudocholinesterase Deficiency Considerations: A Case Study"],"prefix":"10.2344","volume":"67","author":[{"given":"Bryant W.","family":"Cornelius","sequence":"first","affiliation":[{"name":"Assistant Professor and Program Director of Oral Maxillofacial and Dental Anesthesiology, The Ohio State University College of Dentistry and Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Oral Surgery Resident, The Division of Oral Maxillofacial Surgery and Dental Anesthesiology, The Ohio State University College of Dentistry and Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1191","reference":[{"key":"i0003-3006-67-3-177-b01","series-title":"Contin Educ Anaesth Crit Care Pain","first-page":"76","article-title":"Pharmacokinetics of drug infusions","volume":"4","author":"Hill","year":"2004","unstructured":"Hill\n              SA.\n            \n          \n          Pharmacokinetics of drug infusions.\n\t\t\t\t\tContin Educ Anaesth Crit Care Pain.\n\t\t\t\t\t2004;4:76\u201380."},{"key":"i0003-3006-67-3-177-b02","series-title":"Presented at: American Society of Dentist Anesthesiologists 2019 Annual Scientific Session; Orlando, Fla; April 25, 2019.","article-title":"Total intravenous anesthesia for longer office-based procedures","author":"Cornelius","unstructured":"Cornelius\n              BW.\n            \n          \n          Total intravenous anesthesia for longer office-based procedures.\n\t\t\t\t\tPresented at: American Society of Dentist Anesthesiologists 2019 Annual Scientific Session; Orlando, Fla; April 25, 2019."},{"key":"i0003-3006-67-3-177-b03","series-title":"Stanford Anesthesia Cognitive Aid Group","article-title":"Delayed emergence algorithm","author":"Howard","unstructured":"Howard\n              SK,\n            \n            \n              Chu\n              LK,\n            \n            \n              Goldhaberr-Fiebert\n              SN,\n            \n            \n              Gaba\n              DM,\n            \n            \n              Harrison\n              TK.\n            \n          \n          Delayed emergence algorithm.\n\t\t\t\t\tIn:Stanford Anesthesia Cognitive Aid Group.\n\t\t\t\t\tEmergency Manual:\n\t\t\t\t\tCognitive Aids for Perioperative Events.\n\t\t\t\t\t2013. 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