{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:14:05Z","timestamp":1705623245889},"reference-count":22,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This study investigated the involvement of \u03b11- and \u03b22-adrenergic receptors in skeletal muscle blood flow changes during variations in ETCO2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Forty Japanese White rabbits anesthetized with isoflurane were randomly allocated to 1 of 5 groups: phentolamine, metaproterenol, phenylephrine, butoxamine, and atropine. Heart rate (HR), systolic blood pressure (SBP), common carotid artery blood flow (CCBF), masseter muscle tissue blood flow (MBF), and quadriceps muscle tissue blood flow (QBF) were recorded and analyzed at 3 periods: (1) baseline, (2) during hypercapnia (phentolamine and metaproterenol groups) or hypocapnia (phenylephrine, butoxamine, and atropine groups), and (3) during or after receiving vasoactive agents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>MBF and QBF decreased during hypercapnia. The decrease in MBF was smaller than that in QBF. SBP and CCBF increased, while HR decreased. Both MBF and QBF recovered to their baseline levels after phentolamine administration. MBF became greater than its baseline level, while QBF did not fully recover after metaproterenol administration. MBF and QBF increased during hypocapnia. The increase rate in MBF was larger than that in QBF. HR, SBP, and CCBF did not change. Both MBF and QBF decreased to \u223c90% to 95% of their baseline levels after phenylephrine or butoxamine administration. Atropine showed no effects on MBF and QBF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>These results suggest the skeletal muscle blood flow changes observed during hypercapnia and hypocapnia may mainly involve \u03b11-adrenergic but not \u03b22-adrenergic receptor activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2344\/anpr-70-02-02","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T14:56:15Z","timestamp":1687964175000},"page":"58-64","source":"Crossref","is-referenced-by-count":0,"title":["Involvement of \u03b1- and \u03b2-Adrenergic Receptors in Skeletal Muscle Blood Flow Changes During Hyper-\/Hypocapnia in Anesthetized Rabbits"],"prefix":"10.2344","volume":"70","author":[{"given":"Kyotaro","family":"Koshika","sequence":"first","affiliation":[{"name":"*Associate Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"\u2020Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Shionoya","sequence":"additional","affiliation":[{"name":"\u2020Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"\u2020Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Sendai","sequence":"additional","affiliation":[{"name":"\u2020Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Matsuura","sequence":"additional","affiliation":[{"name":"\u2020Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Akiike","sequence":"additional","affiliation":[{"name":"\u2021Senior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"\u00a7Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"2023062814560143800_i1878-7177-70-2-58-b01","doi-asserted-by":"crossref","unstructured":"Ainslie\n              PN,\n        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