{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:15:25Z","timestamp":1773738925689,"version":"3.50.1"},"reference-count":13,"publisher":"American Dental Society of Anesthesiology (ADSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Most invasive dental procedures elicit some degree of bleeding which ultimately leads to clotting and eventual hemostasis. However, patients with inherited coagulation disorders may exhibit prolonged or, in some cases, excessive bleeding requiring multiple perioperative interventions. Von Willebrand disease is the most common inherited coagulopathy and often manifests via easy bruising, epistaxis, or prolonged bleeding. Hemophilia A (factor VII) and B (factor IX) are factor deficiencies that are clinically indistinguishable and managed according to severity and the required dental treatment. Other coagulopathies are rare (ie, inheritance is autosomal recessive) and may only become evident in homozygotes or compound heterozygotes. Current lab values and medical consultation with the patient\u2019s hematologist are imperative prior to rendering invasive dental treatment. There are a myriad of sedation and general anesthesia considerations, including risks for epistaxis with nasal instrumentation and bruising with improper patient positioning. Preoperative treatment with desmopressin or factor replacement may be required and generally should facilitate normal hemostasis. Additional therapies should be considered to help ensure adequate postoperative hemostasis, including pressure dressings, resorbable clotting materials, laser therapy, and oral rinses.<\/jats:p>","DOI":"10.2344\/anpr-71-2_continuing_edu","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T14:45:37Z","timestamp":1723733137000},"page":"87-95","source":"Crossref","is-referenced-by-count":4,"title":["Review of Inherited Coagulation Disorders"],"prefix":"10.2344","volume":"71","author":[{"given":"Tiffany","family":"Hoang","sequence":"first","affiliation":[{"name":"Dental Student, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina A. E.","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Adjunct Assistant Clinical Professor in Anesthesia and Emergency Medicine, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1191","reference":[{"key":"i1878-7177-71-2-87-b01","series-title":"Cecil Essentials of Medicine","first-page":"522","article-title":"Normal hemostasis","author":"Shevell L,","year":"2022","unstructured":"Shevell L,Lee AI. Normal hemostasis. In: Cecil Essentials of Medicine. 10th ed. Elsevier; 2022:522-529."},{"issue":"9","key":"i1878-7177-71-2-87-b02","series-title":"J Can Dent Assoc","first-page":"827","article-title":"Bleeding disorders: characterization, dental considerations and management","volume":"72","author":"Israels S,","year":"2006","unstructured":"Israels S,Schwetz N,Boyar R,McNicol A. Bleeding disorders: characterization, dental considerations and management. J Can Dent Assoc. 2006;72(9):827."},{"issue":"3","key":"i1878-7177-71-2-87-b03","series-title":"Blood Rev","first-page":"153","article-title":"Platelet secretion: from haemostasis to wound healing and beyond","volume":"29","author":"Golebiewska EM,","year":"2015","unstructured":"Golebiewska EM,Poole AW. Platelet secretion: from haemostasis to wound healing and beyond. Blood Rev. 2015;29(3):153-162. doi:10.1016\/j.blre.2014.10.003"},{"key":"i1878-7177-71-2-87-b04","series-title":"Younmans and Winn Neurological Surgery","first-page":"203","article-title":"Coagulation for the neurosurgeon","author":"Nimjee SM,","year":"2023","unstructured":"Nimjee SM,Crofton AR,Oh N,Kirsch W,Haglund MM,Grant GA. Coagulation for the neurosurgeon. In: Younmans and Winn Neurological Surgery. 8th ed. Elsevier; 2023:203-212."},{"issue":"1","key":"i1878-7177-71-2-87-b05","series-title":"Nat Rev Dis Primers","first-page":"45","article-title":"Haemophilia","volume":"7","author":"Berntorp E,","year":"2021","unstructured":"Berntorp E,Fischer K,Hart DP, et al. Haemophilia. Nat Rev Dis Primers. 2021;7(1):45. doi:10.1038\/s41572-021-00278-x"},{"issue":"3","key":"i1878-7177-71-2-87-b06","series-title":"Int Anesthesiol Clin","first-page":"59","article-title":"Von Willebrand disease, hemophilia A and B, and other factor deficiencies","volume":"42","author":"Lee JW.","year":"2004","unstructured":"Lee JW. Von Willebrand disease, hemophilia A and B, and other factor deficiencies. Int Anesthesiol Clin. 2004;42(3):59-76. doi:10.1097\/00004311-200404230-00007"},{"issue":"1","key":"i1878-7177-71-2-87-b07","series-title":"Indian J Pharm Sci","first-page":"7","article-title":"Von Willebrand disease: an overview","volume":"73","author":"Bharati KP,","year":"2011","unstructured":"Bharati KP,Prashanth UR. Von Willebrand disease: an overview. Indian J Pharm Sci. 2011;73(1):7-16. doi:10.4103\/0250-474X.89751"},{"key":"i1878-7177-71-2-87-b08","series-title":"Conn\u2019s Current Therapy 2024","first-page":"458","article-title":"Hemophilia and related conditions","author":"Ozgonenel B,","year":"2024","unstructured":"Ozgonenel B,Kulkarni R,Chitlur M. Hemophilia and related conditions. In: Conn\u2019s Current Therapy 2024. Elsevier; 2024:458-466."},{"issue":"3","key":"i1878-7177-71-2-87-b09","series-title":"Br J Anaesth","first-page":"446","article-title":"Peri-operative management of patients with coagulation disorders","volume":"85","author":"Martlew VJ.","year":"2000","unstructured":"Martlew VJ. Peri-operative management of patients with coagulation disorders. Br J Anaesth. 2000;85(3):446-455. doi:10.1093\/bja\/85.3.446"},{"key":"i1878-7177-71-2-87-b10","series-title":"Smith and Aitkenhead\u2019s Textbook of Anaesthesia","first-page":"250","article-title":"Blood, coagulation, and transfusion","author":"Wake P.","year":"2019","unstructured":"Wake P. Blood, coagulation, and transfusion. In: Smith and Aitkenhead\u2019s Textbook of Anaesthesia. Elsevier; 2019:250-264."},{"key":"i1878-7177-71-2-87-b11","series-title":"Miller\u2019s Anesthesia","first-page":"999","article-title":"Anesthetic implications of concurrent diseases","author":"Kiefer J,","year":"2020","unstructured":"Kiefer J,Mythen M,Roizen MF,Fleisher LA. Anesthetic implications of concurrent diseases. In: Miller\u2019s Anesthesia. 9th ed. Elsevier; 2020:999-1064."},{"key":"i1878-7177-71-2-87-b12","series-title":"Essence of Anesthesia Practice","first-page":"194","author":"Cowell VS. Hemophilia.","year":"2018","unstructured":"Cowell VS. Hemophilia. In: Fleisher LA,Roizen MF,Roizen J, eds. Essence of Anesthesia Practice. Elsevier; 2018:194-195."},{"key":"i1878-7177-71-2-87-b13","series-title":"Miller\u2019s Anesthesia","first-page":"918","article-title":"Preoperative evaluation","author":"Wijeysundera DN,","year":"2020","unstructured":"Wijeysundera DN,Finlayson E. Preoperative evaluation. In: Miller\u2019s Anesthesia. 9th ed. Publisher; 2020:918-998."}],"container-title":["Anesthesia Progress"],"original-title":[],"link":[{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/2\/article-p87.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/2\/article-p87.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/downloadpdf\/journals\/anpr\/71\/2\/article-p87.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:01:50Z","timestamp":1746748910000},"score":1,"resource":{"primary":{"URL":"https:\/\/anesthesiaprogress.kglmeridian.com\/view\/journals\/anpr\/71\/2\/article-p87.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":13,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2344\/anpr-71-2_continuing_edu","relation":{},"ISSN":["1878-7177","0003-3006"],"issn-type":[{"value":"1878-7177","type":"electronic"},{"value":"0003-3006","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}