{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:51:52Z","timestamp":1777884712925,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Recurrent laryngeal papillomatosis (RLP), a chronic disease associated with human papilloma virus (HPV), requires serial surgical procedures for debulking, resulting in debilitating long-term dysphonia, laryngeal scarring, and rarely malignant degeneration. Human papilloma virus 11 tumors have been widely accepted as more aggressive than HPV 6 tumors; however, the clinical course has been difficult to predict at disease onset, and the biologic mediators of proliferation have not been well characterized. A retrospective case review of 43 patients (4 months to 10 years at diagnosis) was performed on children treated for recurrent laryngeal papillomatosis. Patient charts were reviewed for demographic information, age at RLP diagnosis, approximate frequency of surgical intervention, and absolute number of surgical procedures performed. Human papilloma virus subtyping was performed. Expression analysis of the HPV-encoded E6 and E7 oncogenes was performed by reverse-transcriptase polymerase chain reaction. Fourteen patients had subtype 11 (33%) and 29 patients had subtype 6 (67%). As expected, HPV 11 patients showed a more aggressive clinical course than HPV 6 patients. However, 38% of patients with subtype 6 (11 patients) followed a clinical course that mirrored the more severe subtype 11 patients. These patients expressed the disease at a younger age ( P &lt; 0.0002) and showed higher levels of E6 and E7 oncogenes compared to the patients with the more indolent course. Although HPV subtype and early onset of RLP are well characterized prognostic factors, our study documents the significance of E6 and E7 oncogene expression as potential biologic mediators of proliferation and thereby clinical behavior.<\/jats:p>","DOI":"10.2350\/06-09-0160.1","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T09:32:52Z","timestamp":1208770372000},"page":"118-121","source":"Crossref","is-referenced-by-count":15,"title":["E6 and E7 Oncogene Expression by Human Papilloma Virus (HPV) and the Aggressive Behavior of Recurrent Laryngeal Papillomatosis (RLP)"],"prefix":"10.1177","volume":"11","author":[{"given":"Bahig M.","family":"Shehata","sequence":"first","affiliation":[{"name":"Department of Pathology, Children's Healthcare of Atlanta, 1405 Clifton Rd, Atlanta, GA 30322, USA"},{"name":"Department of Pathology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen J.","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Emory University Hospital, 2015 Uppergate Drive, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E.","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery, Emory University Hospital, 2015 Uppergate Drive, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina A.","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Children's Healthcare of Atlanta, 1405 Clifton Road, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"Foulks","sequence":"additional","affiliation":[{"name":"Department of Pathology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Gregoire","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Pathology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, 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