{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:52:05Z","timestamp":1777884725637,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Exencephaly\/anencephaly is a rare neural tube defect occurring early in embryogenesis. We report a 14-week-old fetus with exencephaly in whom central nervous system tissue was developed and preserved. There were 2 symmetrical structures grossly resembling cerebral hemispheres, which on histologic and ultrastructural study, consisted of a combination of ependymoblastomatous rosettes and canals and primitive neural tissue. The brainstem and spinal cord were partially normally formed, although descending tracts were not apparent. No cerebellar tissue was found. The eyes were formed. This appears to represent a rare example of exencephaly not covered by skin, which did not undergo necrosis and early transformation into a residual area cerebrovasculosa, characteristic of anencephaly. It may be appropriate to regard this as a unique neural tube closure defect that might be termed \u201cependymoblastomatous exencephaly.\u201d<\/jats:p>","DOI":"10.2350\/07-06-0295.1","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T15:52:55Z","timestamp":1226073175000},"page":"397-401","source":"Crossref","is-referenced-by-count":2,"title":["Ependymoblastomatous Exencephaly: A Unique Fetal Malformation"],"prefix":"10.1177","volume":"11","author":[{"given":"Michel","family":"Mittelbronn","sequence":"first","affiliation":[{"name":"Institute of Brain Research, University of Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartwig","family":"Wolburg","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidemarie","family":"Kendziorra","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Stopper","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Boeblingen General Hospital, Boeblingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, University of Sao Luis, Sao Luis, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy B.","family":"Rorke-Adams","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"bibr1-07-06-0295.1","first-page":"2","volume-title":"Pathology and Genetics: Developmental Neuropathology","author":"Copp AJ","year":"2004"},{"key":"bibr2-07-06-0295.1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1469-8749.1970.tb03003.x","volume":"22","author":"Emery JL","year":"1970","journal-title":"Dev Med Child Neurol"},{"key":"bibr3-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-99963-5_4"},{"key":"bibr4-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198411000-00006"},{"key":"bibr5-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1077"},{"key":"bibr6-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690470"},{"key":"bibr7-07-06-0295.1","first-page":"863","volume":"72","author":"Lin JK","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"bibr8-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120306"},{"key":"bibr9-07-06-0295.1","first-page":"154","author":"Saint-Hilaire Geoffrey E","year":"1826","journal-title":"Arch G\u00e9n\u00e9r. de M\u00e9decine"},{"key":"bibr10-07-06-0295.1","first-page":"357","author":"Saint-Hilaire Geoffrey E","year":"1826","journal-title":"Ann Sc Naturelles"},{"key":"bibr11-07-06-0295.1","first-page":"75","volume-title":"Inborn Errors of Development","author":"Rubenstein JLR","year":"2004"},{"key":"bibr12-07-06-0295.1","first-page":"3","volume-title":"Pediatric Retina","author":"Barishak YR","year":"2005"},{"key":"bibr13-07-06-0295.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00009-6"},{"key":"bibr14-07-06-0295.1","unstructured":"Lemire RJ, Loeser JD, Leech RW, Alvord ECJr. Normal and abnormal development of the human nervous system. Hagerstown, MD: Harper & Row, 1975;84."}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2350\/07-06-0295.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2350\/07-06-0295.1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2350\/07-06-0295.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:35:51Z","timestamp":1777602951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2350\/07-06-0295.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.2350\/07-06-0295.1"],"URL":"https:\/\/doi.org\/10.2350\/07-06-0295.1","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}