{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:47Z","timestamp":1787025167796,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>Nuclear immunoreactivity for \u03b2-catenin is a useful adjunct for diagnosis of adult desmoid-type fibromatoses, many of which exhibit mutations within the APC\/\u03b2-catenin (Wnt) pathway. Pediatric fibromatoses represent a heterogeneous group of lesions that are diagnostically challenging, especially on biopsy. We studied \u03b2-catenin expression in a variety of pediatric fibroblastic and myofibroblastic lesions. Immunohistochemical nuclear expression of \u03b2-catenin was assessed in 100 tumors. High-level expression of \u03b2-catenin was found in 42% of usual-type or deep fibromatoses (21 of 50). Such expression was not seen in any of the other lesions, including fibrous hamartoma of infancy (0 of 18), juvenile hyaline fibromatosis (0 of 7), infantile digital fibromatosis (0 of 6), myofibromatosis (0 of 5), lipofibromatosis (0 of 4), calcifying aponeurotic fibroma (0 of 3), palmar-plantar fibromatosis (0 of 2), fibromatosis colli (0 of 1), or torticollis (0 of 1). High-level \u03b2-catenin staining is seen in deep \u201cadult-type\u201d fibromatoses occurring in children, although to a lesser frequency than in adult fibromatoses. This indicates that a subset of deep fibromatoses in childhood shares similar mechanisms of tumorigenesis with those in adults. \u03b2-catenin is not expressed in other common pediatric fibroblastic and myofibroblastic lesions, and the Wnt pathway does not appear to play a role in their pathogenesis.<\/jats:p>","DOI":"10.2350\/08-07-0506.1","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T09:30:51Z","timestamp":1224581451000},"page":"292-296","source":"Crossref","is-referenced-by-count":43,"title":["Beta-Catenin Expression in Pediatric Fibroblastic and Myofibroblastic Lesions: A Study of 100 Cases"],"prefix":"10.1177","volume":"12","author":[{"given":"Khin","family":"Thway","sequence":"first","affiliation":[{"name":"Department of Histopathology, Royal Marsden Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Histopathology, Great Ormond Street Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Department of Histopathology, University College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Sebire","sequence":"additional","affiliation":[{"name":"Department of Paediatric Histopathology, Great Ormond Street Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"bibr1-08-07-0506.1","first-page":"1193","volume":"59","author":"Eccles DM","year":"1996","journal-title":"Am J Hum Genet"},{"key":"bibr2-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1921"},{"key":"bibr3-08-07-0506.1","first-page":"329","volume":"151","author":"Alman BA","year":"1997","journal-title":"Am J Pathol"},{"key":"bibr4-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203041"},{"key":"bibr5-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880374"},{"key":"bibr6-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200210000-00006"},{"key":"bibr7-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819109064791"},{"key":"bibr8-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800272"},{"key":"bibr9-08-07-0506.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02794.x"},{"key":"bibr10-08-07-0506.1","first-page":"257","volume-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Weiss SW","year":"2008","edition":"5"},{"key":"bibr11-08-07-0506.1","first-page":"83","volume-title":"World Health Organisation Classification of Tumours. 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