{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:22:55Z","timestamp":1792092175690,"version":"4.4.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>We report the clinical features and pathological findings in 9 cases of intrapartum and early neonatal death associated with embolism of brain tissue to the pulmonary and systemic circulation following difficult delivery. All except 1 of the cases in this series were born at, or near to, term, were vertex presentations, and were normally grown. All followed instrumental delivery and in 5, at least one mode of assisted delivery had failed. Whilst some evidence of cranial trauma was present in 7 cases, only 3 had skull fractures and 7 showed intracranial hemorrhage, although this was described as minor in 3. Emboli of brain tissue were identified in the pulmonary circulation in all cases. Fragments of brain were also seen in vessels of other organs, in particular the heart, in 6 cases. Emboli were highlighted by immunostaining for glial fibrillary acid protein. Brain emboli should be sought in all post mortems of unexplained intrapartum or early neonatal death following difficult delivery, even in the absence of overt cranial trauma. Disseminated intravascular coagulation is a frequent association. Extensive sampling for histology, particularly of the lungs and coronary vessels, is essential if this condition is not to be missed.<\/jats:p>","DOI":"10.2350\/09-02-0607-oa.1","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T17:24:23Z","timestamp":1247505863000},"page":"464-468","source":"Crossref","is-referenced-by-count":5,"title":["Embolism of Brain Tissue in Intrapartum and Early Neonatal Deaths: Report of 9 Cases"],"prefix":"10.1177","volume":"12","author":[{"given":"Phillip","family":"Cox","sequence":"first","affiliation":[{"name":"Department of Histopathology, Birmingham Women's Hospital, Metchley Park Road, Birmingham, B15 2TG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Complesso S.Giovanni-Addolorata, Servizio di Anatomia ed Istologia Patologica, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Lazda","sequence":"additional","affiliation":[{"name":"Department of Histopathology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Nash","sequence":"additional","affiliation":[{"name":"Department of Histopathology, St. George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Jeffrey","sequence":"additional","affiliation":[{"name":"Department of Histopathology, St. George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Ostojic","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Birmingham Women's Hospital, Metchley Park Road, Birmingham, B15 2TG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wigglesworth","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Rd, London, W12 0HS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr1-09-02-0607-OA.1","first-page":"244","volume":"24","author":"Abrikossov AJ","year":"1913","journal-title":"Centrabl Allg Pathol Anat"},{"key":"bibr2-09-02-0607-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(91)90270-J"},{"key":"bibr3-09-02-0607-OA.1","first-page":"217","volume":"114","author":"Hauck AJ","year":"1990","journal-title":"Arch Pathol Lab Med"},{"key":"bibr4-09-02-0607-OA.1","unstructured":"Wigglesworth JS. 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