{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:56:58Z","timestamp":1783587418509,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>The objective of this study was to analyze the histopathological patterns of inflammation, distribution, severity, and degree of gastric mucosa of Helicobacter pylori (Hp)\u2013infected children in Northern Mexico, as well as the correlation between colonization density and inflammation intensity. We carried out a cross-sectional study of gastric biopsies performed on children ranging from 2 to 17 years of age who underwent upper gastrointestinal endoscopy for diverse gastroduodenal disorders. This study includes only children who were found to be Hp carriers, with positive results for tests of Hp antigens in feces and in gastric biopsy studies. We studied 107 patients (age 8.2 \u00b1 3.7 years). In 47.7% of patients, the density of Hp colonization was low; only 21.5% had a marked density. Mononuclear leukocyte infiltration showed a similar distribution. Thirty-seven percent of patients had follicular gastritis. An acute inflammatory response was absent in 65% and mild in 20.6% of patients. When inflammation was present, it was primarily located in the antrum (79%). There were no cases of intestinal metaplasia or atrophy. A link was found between Hp density and age, infiltration by mononuclear cells, the presence of follicular gastritis, and the level of neutrophil infiltration ( P = 0.001). Despite the high rates of Hp infection in the region, the histopathological findings in these children were mild and were limited primarily to the antral mucosa. These data indicate the need to study the behavior of this disease in children in diverse study populations to provide localized prevention and treatment strategies.<\/jats:p>","DOI":"10.2350\/09-12-0754-oa.1","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T14:50:11Z","timestamp":1280155811000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic Gastritis Associated with\n                    <i>Helicobacter pylori<\/i>\n                    in Mexican Children: Histopathological Patterns"],"prefix":"10.1177","volume":"14","author":[{"given":"Yolanda","family":"Jaramillo-Rodriguez","sequence":"first","affiliation":[{"name":"Department of General Pathology, General Hospital No. 16, Mexican Institute of Social Security (IMSS), Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Nares-Cisneros","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition, Medical High Specialty Unit (UMAE) No. 71, IMSS, Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica Araceli","family":"Mart\u00ednez-Ordaz","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Research Unit, Medical High Specialty Unit (UMAE) No. 71, IMSS, Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Manuel","family":"Velasco-Rodriguez","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Research Unit, Medical High Specialty Unit (UMAE) No. 71, IMSS, Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carlos L\u00f3pez","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Biomedic Research Center, School of Medicine, Universidad Autonoma de Coahuila, Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Enrique","family":"Manr\u00edquez-Covarrubias","sequence":"additional","affiliation":[{"name":"Department of General Pathology, General Hospital No. 16, Mexican Institute of Social Security (IMSS), Torreon, Coahuila, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"bibr1-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05273-3"},{"key":"bibr2-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(00)00099-0"},{"key":"bibr3-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1086\/515663"},{"key":"bibr4-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.43"},{"key":"bibr5-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00493.x"},{"key":"bibr6-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00603.x"},{"key":"bibr7-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0553-y"},{"key":"bibr8-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00632.x"},{"key":"bibr9-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00514.x"},{"key":"bibr10-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.10.012"},{"key":"bibr11-09-12-0754-OA.1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi207"},{"key":"bibr12-09-12-0754-OA.1","first-page":"576","volume":"26","author":"El-Mouzan 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