{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:52:49Z","timestamp":1777884769411,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Previous studies have shown differences in expression levels of apoptosis regulatory proteins in non-Hodgkin lymphomas (NHLs) and indicated the correlation of procaspase-3 (proC-3) and caspase-3 activation to the response of chemotherapy. We investigated whether proC-3 expression in tumor biopsies of childhood NHLs is related to clinical outcome. Formalin-fixed paraffin-embedded tissues from 58 children with NHL were evaluated for proC-3 expression by immunochemistry analysis. The study included 20 cases of Burkitt lymphoma, 7 cases of diffuse large B-cell lymphoma, 18 cases of anaplastic large cell lymphoma (ALCL), and 13 cases of precursor lymphoblastic lymphoma. The highest expression level of proC-3 was observed in ALCL. In the multivariate analysis the higher clinical stage of disease and higher expression level of proC-3 were independent and appear to be significant prognostic factors of treatment failure. Our results suggest that the high expression level of proC-3 may be a powerful independent predictor of response to chemotherapy and progression-free survival in childhood NHLs.<\/jats:p>","DOI":"10.2350\/10-01-0779-oa.1","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T12:08:40Z","timestamp":1282219720000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunohistochemical Expression of Procaspase-3 and Its Clinical Significance in Childhood Non-Hodgkin Lymphomas"],"prefix":"10.1177","volume":"14","author":[{"given":"Grazyna","family":"Wrobel","sequence":"first","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University, Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Maldyk","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pathology, Medical University, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernarda","family":"Kazanowska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University, Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Rapala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University, Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucyna","family":"Maciejka-Kapuscinska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University, Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rados\u0142aw","family":"Chaber","sequence":"additional","affiliation":[{"name":"Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University, Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"bibr1-10-01-0779-OA.1","doi-asserted-by":"crossref","unstructured":"Reiter A. 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