{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:52:50Z","timestamp":1777884770920,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Juvenile polyposis of infancy is a rare genetic disorder, involving multiple hamartomatous polyps of the gastrointestinal tract, which usually has a very aggressive clinical course and is often fatal. It is characterized by early onset (during the 1st months of life) and by diffuse juvenile polyposis with anemia, recurrent gastrointestinal bleeding, diarrhea, rectal prolapse, intussusception, protein-losing enteropathy, starvation, and malnutrition. There is a hypothesis that mutation of the tumor-suppressor genes BMPR1A and PTEN, located on the long arm of chromosome 10, is associated with the development of this disease. Medical treatment for this disorder is challenging and should be conservative whenever possible. We present the case of a 3-year-old girl with juvenile polyposis of infancy who eventually died from mesenteric artery thrombosis during surgical colectomy. Karyotype of the patient showed a paracentric inversion in 10q and a deletion in 10p. We will briefly comment on some genetic considerations of this disease.<\/jats:p>","DOI":"10.2350\/10-01-0791-cr.1","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T16:13:36Z","timestamp":1269447216000},"page":"486-491","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Juvenile Polyposis of Infancy Associated with Paracentric Inversion and Deletion of Chromosome 10 in a Hispanic Patient: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"given":"Roberto","family":"Vargas-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Pathology Department, \u201cHospital Puebla\u201d Privada de las Ramblas No 4, Desarrollo territorial Atlixcayotl, CP 72197 Puebla Pue., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"de la Torre-Mondrag\u00f3n","sequence":"additional","affiliation":[{"name":"Surgery Department, Hosp\u00ectal para el Ni\u00f1o Poblano, Blvd. Del Nino Poblano 5307 Col. Concepcion la Cruz, CP. 72190, Puebla Pue., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Aparicio-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Genetic Department, Hospital para el Ni\u00f1o Poblano, Blvd. Del Nino Poblano 5307 Col. Concepcion la Cruz, CP. 72190, Puebla Pue., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Froylan","family":"Paniagua-Morgan","sequence":"additional","affiliation":[{"name":"Surgery Department, Hosp\u00ectal para el Ni\u00f1o Poblano, Blvd. Del Nino Poblano 5307 Col. Concepcion la Cruz, CP. 72190, Puebla Pue., Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Oncohematology Department, Hospital para el Ni\u00f1o Poblano, Blvd. Del Nino Poblano 5307 Col. 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