{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:36:32Z","timestamp":1785501392459,"version":"3.56.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"\n Despite an intensive pro-inflammatory response, the immune system is unable to clear the organism in Helicobacter pylori gastritis. Regulatory T (Treg) cells, which suppress the immune response of antigen-specific T cells, have recently been demonstrated to play a key role in chronic inflammation by immunologic tolerance. The purpose of our study was to investigate the histopathology, FOXP3+CD4+CD25\n high<\/jats:sup>\n Treg (FOXP3+ Treg) cell expression, and immune responses in children with H. pylori infection. Twenty-four H. pylori\u2013positive and 24 H. pylori\u2013negative children who underwent esophagogastroduodenoscopy for dyspeptic symptoms were included. Histopathologic grading according to the updated Sydney classification and immunohistochemical stains for FOXP3, transforming growth factor\u2013\u03b21 (TGF-\u03b21), and CD4 were performed. Histopathologic bacterial density score, gastritis activity score, and chronic inflammation score were higher in the H. pylori\u2013positive group than in the negative group ( P < 0.01). The number of FOXP3+Treg cells and CD4+T cells and the grade of TGF-\u03b21 expression were significantly increased in the H. pylori\u2013positive group compared to the negative group ( P < 0.01). The number of FOXP3+Treg cells correlated positively with the grade of TGF-\u03b21 expression regardless of H. pylori status ( P < 0.05). The number of FOXP3+Treg cells and the grade of TGF-\u03b21 expression correlated positively with H. pylori density, gastritis activity score, and chronic inflammation score regardless of H. pylori status ( P < 0.01). These findings indicate that FOXP3+Treg cells could play a role in persistent H. pylori infection.\n <\/jats:p>","DOI":"10.2350\/11-06-1046-oa.1","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T16:24:24Z","timestamp":1326990264000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["FOXP3+ Regulatory T Cells in Children with\n Helicobacter Pylori<\/i>\n Infection"],"prefix":"10.1177","volume":"15","author":[{"given":"Ky Young","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ewha Womans University School of Medicine, Seoul 158-710, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Sun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ewha Womans University School of Medicine, Seoul 158-710, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Wan","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ewha Womans University School of Medicine, Seoul 158-710, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"bibr1-11-06-1046-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91782-Y"},{"key":"bibr2-11-06-1046-OA.1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.27.8.1870-1873.1989"},{"key":"bibr3-11-06-1046-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00693.x"},{"key":"bibr4-11-06-1046-OA.1","first-page":"153","volume":"46","author":"Kim N","year":"2005","journal-title":"Korean J 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