{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:10:39Z","timestamp":1780384239450,"version":"3.54.1"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Coronal clefts\u2014a radiolucent band running through at least one vertebral body, visualized in the lateral spinal radiograph and discussed as a physiological variation of the fetal vertebral ossification pattern\u2014are often found in fetal autopsies with trisomies. Published studies are missing concerning the question of whether this finding could serve as a diagnostic radiological or even ultrasonographic sign. We studied the incidence of radiological coronal clefts and their association with chromosomal aberrations in 443 fetuses (mostly medically induced abortions). In 42 of the 443 fetuses (9.5%), coronal clefts were visualized. The majority (71%) were localized in the lumbar spine. No cervical or singular sacral clefts were detected. Twenty-five of the 42 fetuses (60%) displaying coronal clefts had chromosomal aberrations, either as a trisomy (13 or 21) or as monosomy X. Histologically, coronal clefts showed a missing central ossification of the vertebral body. Remnants of the notochord could be excluded. Hence, coronal clefts represent a variant ossification of vertebral bodies in fetal development that is found almost exclusively in fetuses with chromosomal aberrations or severe congenital malformations. This finding could be a helpful supplement to prenatal diagnostics and fetal autopsy. On the other hand, the genetic diagnosis of chromosomal aberration, especially trisomy, does not automatically imply the presence of coronal clefts.<\/jats:p>","DOI":"10.2350\/12-04-1186-oa.1","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T15:12:18Z","timestamp":1351696338000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Coronal Vertebral Clefts: A Radiological Indicator for Chromosomal Aberrations"],"prefix":"10.1177","volume":"16","author":[{"given":"Elke","family":"Doberentz","sequence":"first","affiliation":[{"name":"Department of Pediatric Pathology, University Clinic Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany"},{"name":"Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Section of Pediatric Genetics, Department of Pediatrics, University Hospital Freiburg, Hugstetter Stra\u00dfe 49, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gembruch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine, University Clinic Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg Andreas","family":"Gasser","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research \u2013 Musculoskeletal Division, 4000 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pathology, University Clinic Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2002276"},{"key":"bibr2-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.3109\/17453676908989481"},{"key":"bibr3-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(89)80079-0"},{"key":"bibr4-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.3109\/17453678308996590"},{"key":"bibr5-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050462"},{"key":"bibr6-12-04-1186-OA.1","first-page":"327","volume":"21","author":"Fielden P","year":"1970","journal-title":"Radiology"},{"key":"bibr7-12-04-1186-OA.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02386830"},{"key":"bibr8-12-04-1186-OA.1","volume-title":"Imaging of the Newborn, Infant, and Young Child","author":"Swischuk LE","year":"1997","edition":"4"},{"key":"bibr9-12-04-1186-OA.1","unstructured":"Epstein BS. The spine: A Radiological Text and Atlas. 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