{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:11:56Z","timestamp":1778919116449,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>The cause and pathogenesis of gastroschisis are uncertain. We report the autopsy and placental pathology of a stillbirth at 20 gestational weeks, in which gastroschisis was accompanied by destructive lesions in the cerebral cortex and brainstem, as well as cardiac calcification, consistent with ischemic injury during the 2nd trimester. An important potential underlying mechanism explaining the fetal abnormalities is the presence of infarcts in the placenta, indicative at this gestational age of maternal vascular underperfusion. The association of gastroschisis with ischemic lesions in the brain, heart, and placenta in this case supports the concept that gastroschisis, at least in some instances, may result from vascular event(s) causing disruption of the fetal abdominal wall and resulting in the extrusion of the abdominal organs, as well as hypoxic\u2013ischemic brain and cardiac injury.<\/jats:p>","DOI":"10.2350\/13-03-1316-cr.1","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T09:36:13Z","timestamp":1375176973000},"page":"391-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Gastroschisis, Destructive Brain Lesions, and Placental Infarction in the Second Trimester Suggest a Vascular Pathogenesis"],"prefix":"10.1177","volume":"16","author":[{"given":"Rebecca D.","family":"Folkerth","sequence":"first","affiliation":[{"name":"Department of Pathology (Neuropathology), Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA"},{"name":"Department of Pathology, Children's Hospital Boston, and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Habbe","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the Black Hills, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theonia K.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Pathology (Neuropathology), Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA"},{"name":"Department of Pathology, Children's Hospital Boston, and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children's Hospital Boston, and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Gromer","sequence":"additional","affiliation":[{"name":"Center for Health Outcomes and Prevention Research, Sanford Research, Sioux Falls, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Sens","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"bibr1-13-03-1316-CR.1","unstructured":"Brunicardi F, Andersen D, Billiar T, Dunn D, Hunter J, and Pollock, eds. 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