{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:18:10Z","timestamp":1778876290211,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Numerous studies have addressed the significance of marginal and membranous umbilical cord (UC) insertion. Recent reports suggest that an eccentrically inserted UC may also be important. This case-control study assessed the potential relevance of peripheral insertion of UC (PIUC), defined as &lt;3 cm from the nearest margin. Singleton placentas (n = 1418) submitted to the pathology department over an 18-month period were analyzed. Each case of PIUC (n = 119) was matched with a control placenta of the same gestational age. Placentas with marginal or membranous UC and multiple gestations were excluded. The overall prevalence of PIUC was 8.4%, but PIUC frequency was significantly increased in premature births at &lt;28 weeks (21.4%, P &lt; 0.001). There was no association with other adverse pregnancy outcomes. PIUC was associated with decreased placental weight Z-score (\u22120.69 \u00b1 0.92 versus \u22120.22 \u00b1 1.3, P = 0.0056), but not fetal weight Z-score, suggesting increased utilization of placental reserve. PIUC was also associated with relatively elongated placentas (length minus width: 2.6 \u00b1 3.2 versus 1.0 \u00b1 3.1, P = 0.006). PIUC tended to be more frequent in young primiparous mothers and was significantly less common in women with a history of prior curettage (66% vs 50%, P = 0.013). These data, together with equivalent rates of prior cesarean section, multiparity, and advanced maternal age, support a primary developmental disorder as opposed to secondary placental migration due to underlying uterine abnormalities (\u201ctrophotropism\u201d). Except for a borderline significant association with findings suggestive of maternal malperfusion ( P = 0.078), PIUC was not associated with other placental lesions.<\/jats:p>","DOI":"10.2350\/13-05-1337-oa.1","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T05:09:47Z","timestamp":1378876187000},"page":"399-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Peripheral Insertion of Umbilical Cord"],"prefix":"10.1177","volume":"16","author":[{"given":"Guangju","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W.","family":"Redline","sequence":"additional","affiliation":[{"name":"Department of Pathology, Department of Reproductive Biology, University Hospitals Case 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