{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:53:46Z","timestamp":1777884826532,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>The cone-rod homeobox (CRX) is a gene that belongs to the member of the orthodenticle homeobox (Otx) family, with important function in development and differentiation of retinal and pineal cells. Moreover, CRX appears to be specifically expressed in pineal tumors and retinoblastomas. We performed an immunohistochemical study on 91 pediatric and adult central nervous system tumors, plus 2 normal brain samples. Our results demonstrated that CRX is expressed not only in pineal parenchymal tumors and retinoblastoma, but also in a some medulloblastomas and supratentorial primitive neuroectodermal tumors. None of the glial tumors screened were positive for CRX. In conclusion, CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors.<\/jats:p>","DOI":"10.2350\/13-06-1346-oa.1","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T18:20:03Z","timestamp":1392920403000},"page":"85-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Is CRX Protein a Useful Marker in Differential Diagnosis of Tumors of the Pineal Region?"],"prefix":"10.1177","volume":"17","author":[{"given":"Antonelli","family":"Manila","sequence":"first","affiliation":[{"name":"Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Novello","family":"Mariangela","sequence":"additional","affiliation":[{"name":"Department of Pathology, Policlinico Gemelli Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauriola","family":"Libero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Policlinico Gemelli Largo Agostino Gemelli 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianno","family":"Francesca","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buttarelli Francesca","family":"Romana","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, Sapienza University Viale dell'Universit\u00e0, 30, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giangaspero","family":"Felice","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University Viale Regina Elena 324, 00161 Rome, Italy"},{"name":"IRCCS Neuromed, Via Artinese 18, 86077 Pozzilli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"bibr1-13-06-1346-OA.1","volume-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004\u20132008","author":"CBTRUS","year":"2012"},{"key":"bibr2-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-005-1181-x"},{"key":"bibr3-13-06-1346-OA.1","unstructured":"David N, Louis HO, Wiestler OD, Cavenee WK. Tumours of the Pineal Region. WHO Classification of Tumours of the Central Nervous System. Lyon: IARC Press, 2007;121\u2013126."},{"key":"bibr4-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181f895a4"},{"key":"bibr5-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007932"},{"key":"bibr6-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07405.x"},{"key":"bibr7-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06322.x"},{"key":"bibr8-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012713506549"},{"key":"bibr9-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03773.x"},{"key":"bibr10-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1155"},{"key":"bibr11-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2011.05.006"},{"key":"bibr12-13-06-1346-OA.1","first-page":"196","volume":"4","author":"Kreutz J","year":"2010","journal-title":"JBR-BTR"},{"key":"bibr13-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199509000-00008"},{"key":"bibr14-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227661"},{"key":"bibr15-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003088"},{"key":"bibr16-13-06-1346-OA.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3182649dad"}],"container-title":["Pediatric and Developmental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2350\/13-06-1346-OA.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2350\/13-06-1346-OA.1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2350\/13-06-1346-OA.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:39:47Z","timestamp":1777603187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2350\/13-06-1346-OA.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.2350\/13-06-1346-OA.1"],"URL":"https:\/\/doi.org\/10.2350\/13-06-1346-oa.1","relation":{},"ISSN":["1093-5266","1615-5742"],"issn-type":[{"value":"1093-5266","type":"print"},{"value":"1615-5742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}