{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:18:50Z","timestamp":1782962330138,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Dev Pathol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Vitamin D is required for calcium absorption and normal bone mineralization; it has a key role in immune regulation against infections and is believed to be involved in immunomodulation in asthma. We did a retrospective analysis of 52 postmortem cases (aged 2 days to 10 years). Seventeen children had vitamin D deficiency (&lt;25 nmol\/L); 24 children had vitamin D insufficiency (25\u201349 nmol\/L); 10 children had suboptimal vitamin D levels (50\u201379 nmol\/L); and only 1 child had adequate levels (\u226580 nmol\/L). Three infants had fractures. Growth plate histology was abnormal in 10 cases with vitamin D deficiency (59%), but radiology was abnormal in only 3 of those cases. Eight infants (33%) with vitamin D insufficiency had abnormal histology, but radiology was normal in all cases. In 3 children hypocalcemia due to vitamin D deficiency was considered accountable for death; they all showed radiological and histological rickets: 2 babies had cardiomyopathy and a 3-year-old had hypocalcemic seizures. Children from all ethnic groups had a high proportion of low vitamin D levels. Vitamin D deficiency (the most common form of pediatric metabolic bone disease) is preventable and treatable. Profound hypocalcemia due to severe vitamin D deficiency can cause unexpected death in babies and young children. Measuring serum vitamin D levels postmortem may provide invaluable information on sudden unexplained death in \u2018at-risk\u2019 children. Vitamin D deficiency may be relevant in childhood asthma and in children with multiple infections and babies with bone fractures. Postmortem vitamin D levels are stable and easy to measure.<\/jats:p>","DOI":"10.2350\/14-05-1491-oa.1","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T16:13:36Z","timestamp":1405354416000},"page":"455-464","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Does Low Vitamin D Have a Role in Pediatric Morbidity and Mortality? An Observational Study of Vitamin D in a Cohort of 52 Postmortem Examinations"],"prefix":"10.1177","volume":"17","author":[{"given":"Irene","family":"Scheimberg","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Barts Health NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"bibr1-14-05-1491-OA.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2007.04.004"},{"key":"bibr2-14-05-1491-OA.1","unstructured":"Kiho L, Scheimberg I. Is it worth measuring vitamin D postmortem? Poster presentation number 35. 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