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We report 2 cases of SS-HSCR with skip areas in the distal rectum, 1 of which led to a false-negative diagnosis by suction rectal biopsy. These 2 cases of SS-HSCR, along with others in the literature, highlight the point that ganglionic skip segments can confuse clinicians and lead to inadequate bowel resection, diagnostic delay, or a false-negative diagnosis. The pathogenesis of SS-HSCR is discussed in light of recent discoveries regarding transmesenteric migration of vagal neural crest cells and the role of sacral neural crest cells in hindgut neurodevelopment.<\/jats:p>","DOI":"10.2350\/15-08-1686-oa.1","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T10:57:58Z","timestamp":1442314678000},"page":"123-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Distal Rectal Skip-Segment Hirschsprung Disease and the Potential for False-Negative Diagnosis"],"prefix":"10.1177","volume":"19","author":[{"given":"Alexander","family":"Coe","sequence":"first","affiliation":[{"name":"University of Nevada School of Medicine, Reno, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Avansino","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington and 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