{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:46:57Z","timestamp":1791323217095,"version":"4.3.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.2353\/ajpath.2006.050375","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T19:40:05Z","timestamp":1174074005000},"page":"805-811","source":"Crossref","is-referenced-by-count":56,"title":["Nerve Damage in Mycobacterium ulcerans-Infected Mice"],"prefix":"10.1016","volume":"168","author":[{"given":"Masamichi","family":"Goto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Nakanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thida","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norishige","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2006.050375_bib1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(99)01156-3","article-title":"Mycobacterium ulcerans infection","volume":"354","author":"van der Werf","year":"1999","journal-title":"Lancet"},{"key":"10.2353\/ajpath.2006.050375_bib2","first-page":"163","article-title":"Buruli ulcer disease: Mycobacterium ulcerans infection","volume":"78","year":"2003","journal-title":"Wkly Epidemiol Rec"},{"key":"10.2353\/ajpath.2006.050375_bib3","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1126\/science.283.5403.854","article-title":"Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence","volume":"283","author":"George","year":"1999","journal-title":"Science"},{"key":"10.2353\/ajpath.2006.050375_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/path.1700600111","article-title":"A new mycobacterial infection in man","volume":"60","author":"MacCallum","year":"1948","journal-title":"J Pathol Bacteriol"},{"key":"10.2353\/ajpath.2006.050375_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0092-8674(00)00142-2","article-title":"Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae","volume":"103","author":"Ng","year":"2000","journal-title":"Cell"},{"key":"10.2353\/ajpath.2006.050375_bib6","first-page":"201","article-title":"Phenolic glycolipid-1 (PGL-1) in Buruli ulcer lesions: first demonstration by immuno-histochemistry","volume":"70","author":"Mwanatambwe","year":"2002","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"10.2353\/ajpath.2006.050375_bib7","first-page":"477","article-title":"Epitope mapping of twelve monoclonal antibodies against the phenolic glycolipid-I of M. leprae","volume":"65","author":"Fujiwara","year":"1997","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"10.2353\/ajpath.2006.050375_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/JCM.37.1.206-208.1999","article-title":"Comparison of two PCRs for detection of Mycobacterium ulcerans","volume":"37","author":"Guimaraes-Peres","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.2353\/ajpath.2006.050375_bib9","first-page":"121","article-title":"Mycobacterium leprae typing by genomic diversity and global distribution of genotypes","volume":"68","author":"Matsuoka","year":"2000","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"10.2353\/ajpath.2006.050375_bib10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/brain\/93.4.831","article-title":"Isoniazid neuropathy in man: quantitative electron microscope study","volume":"93","author":"Ochoa","year":"1970","journal-title":"Brain"},{"key":"10.2353\/ajpath.2006.050375_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/thx.45.5.419","article-title":"Exacerbation of isoniazid induced peripheral neuropathy by pyridoxine","volume":"45","author":"Nisar","year":"1990","journal-title":"Thorax"},{"key":"10.2353\/ajpath.2006.050375_bib12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/pgmj.48.565.667","article-title":"Peripheral neuropathy with ethambutol","volume":"48","author":"Tugwell","year":"1972","journal-title":"Postgrad Med J"},{"key":"10.2353\/ajpath.2006.050375_bib13","first-page":"347","article-title":"Peripheral neuropathy associated with treatment for multidrug-resistant tuberculosis","volume":"7","author":"Shin","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.2353\/ajpath.2006.050375_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/jnnp.73.6.769","article-title":"Peripheral nerve granuloma in a patient with tuberculosis","volume":"73","author":"Orrell","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.2353\/ajpath.2006.050375_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/00313029600169733","article-title":"Pseudoepitheliomatous hyperplasia in Mycobacterium ulcerans infection","volume":"28","author":"Hayman","year":"1996","journal-title":"Pathology"},{"key":"10.2353\/ajpath.2006.050375_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5025\/hansen.69.93","article-title":"Clinico-histopathological findings of Buruli ulcer","volume":"69","author":"Mwanatambwe","year":"2000","journal-title":"Nihon Hansenbyo Gakkai Zasshi"},{"key":"10.2353\/ajpath.2006.050375_bib17","first-page":"121","article-title":"Bacteriologie et pathologie humaine et experimentale des ulceres a Mycobacterium ulcerans. [Bacteriology and human and experimental pathology of ulcers caused by Mycobacterium ulcerans]","volume":"45","author":"Pattyn","year":"1965","journal-title":"Ann Soc Belg Med Trop"},{"key":"10.2353\/ajpath.2006.050375_bib18","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/IAI.9.6.1114-1122.1974","article-title":"Cytotoxic activity of Mycobacterium ulcerans","volume":"9","author":"Read","year":"1974","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.050375_bib19","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1128\/AAC.45.11.3109-3112.2001","article-title":"Activities of new macrolides and fluoroquinolones against Mycobacterium ulcerans infection in mice","volume":"45","author":"Bentoucha","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.2353\/ajpath.2006.050375_bib20","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1128\/AAC.46.10.3193-3196.2002","article-title":"Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice","volume":"46","author":"Dega","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.2353\/ajpath.2006.050375_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0924-8579(00)00306-X","article-title":"In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans","volume":"17","author":"Dhople","year":"2001","journal-title":"Int J Antimicrob Agents"},{"key":"10.2353\/ajpath.2006.050375_bib22","first-page":"333","article-title":"Comparison of inhibitory effect of rifalazil and rifampicin against Mycobacterium ulcerans infection induced in mice","volume":"79","author":"Nakanaga","year":"2004","journal-title":"Kekkaku"},{"key":"10.2353\/ajpath.2006.050375_bib23","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMc045252","article-title":"Medical mystery: painless ulcers\u2014the answer","volume":"350","author":"Morris-Jones","year":"2004","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2006.050375_bib24","first-page":"515","article-title":"An ultrastructural study of dermal nerves in early human leprosy","volume":"55","author":"Chandi","year":"1987","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"10.2353\/ajpath.2006.050375_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5025\/hansen.70.141","article-title":"A morphological study of nerve biopsies in leprous neuropathy","volume":"70","author":"Kimura","year":"2001","journal-title":"Nihon Hansenbyo Gakkai Zasshi"},{"key":"10.2353\/ajpath.2006.050375_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1128\/IAI.68.2.877-883.2000","article-title":"A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells","volume":"68","author":"George","year":"2000","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.050375_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1128\/IAI.72.1.123-132.2004","article-title":"Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone","volume":"72","author":"Daniel","year":"2004","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.050375_bib28","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4269\/ajtmh.1999.61.694","article-title":"Transmission of Mycobacterium ulcerans to the nine-banded armadillo","volume":"61","author":"Walsh","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.2353\/ajpath.2006.050375_bib29","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1128\/IAI.73.10.6299-6310.2005","article-title":"Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice","volume":"73","author":"Oliveira","year":"2005","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.050375_bib30","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1462-5822.2005.00546.x","article-title":"Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin","volume":"7","author":"Coutanceau","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.2353\/ajpath.2006.050375_bib31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1128\/IAI.71.2.774-783.2003","article-title":"Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence","volume":"71","author":"Mve-Obiang","year":"2003","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.050375_bib32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archderm.1974.01630110073023","article-title":"Toxin of Mycobacterium ulcerans: production and effects in guinea pig skin","volume":"110","author":"Krieg","year":"1974","journal-title":"Arch Dermatol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010621414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010621414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T22:23:06Z","timestamp":1587421386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010621414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0002944010621414"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2006.050375","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}