{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:44:50Z","timestamp":1772894690032,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.2353\/ajpath.2006.050555","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T15:40:51Z","timestamp":1174059651000},"page":"1531-1541","source":"Crossref","is-referenced-by-count":29,"title":["p21Cip1 Is Required for the Development of Monocytes and Their Response to Serum Transfer-induced Arthritis"],"prefix":"10.1016","volume":"168","author":[{"given":"John C.","family":"Scatizzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Hutcheson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Bickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Klosowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"G. Kenneth","family":"Haines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harris","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2006.050555_bib1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.2353\/ajpath.2006.050555_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/bies.950190408","article-title":"Cyclins, cyclin-dependent kinases and differentiation","volume":"19","author":"Gao","year":"1997","journal-title":"BioEssays"},{"key":"10.2353\/ajpath.2006.050555_bib3","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.1074\/jbc.275.14.10477","article-title":"Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1\/waf1\/sdi1) in DNA replication and transcription","volume":"275","author":"Kitaura","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2006.050555_bib4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/381804a0","article-title":"A non-enzymatic p21 protein inhibitor of stress-activated protein kinases","volume":"381","author":"Shim","year":"1996","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.050555_bib5","doi-asserted-by":"crossref","first-page":"18794","DOI":"10.1074\/jbc.M001601200","article-title":"Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1\/CIP1\/SDI1","volume":"275","author":"Coqueret","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2006.050555_bib6","first-page":"6234","article-title":"Tumor susceptibility of p21(Waf1\/Cip1)-deficient mice","volume":"61","author":"Martin-Caballero","year":"2001","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2006.050555_bib7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.20031685","article-title":"Deficiency of the cyclin kinase inhibitor p21(WAF-1\/CIP-1) promotes apoptosis of activated\/memory T cells and inhibits spontaneous systemic autoimmunity","volume":"199","author":"Lawson","year":"2004","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2006.050555_bib8","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.4049\/jimmunol.167.7.4067","article-title":"Role of cyclin kinase inhibitor p21 in systemic autoimmunity","volume":"167","author":"Santiago-Raber","year":"2001","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/72272","article-title":"The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development","volume":"6","author":"Balomenos","year":"2000","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2006.050555_bib10","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1161\/01.CIR.0000148681.01282.89","article-title":"Absence of p21Waf1\/Cip1\/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis","volume":"110","author":"Merched","year":"2004","journal-title":"Circulation"},{"key":"10.2353\/ajpath.2006.050555_bib11","series-title":"Current Molecular Medicine: Principles of Molecular Rheumatology","first-page":"325","article-title":"Rheumatoid arthritis","author":"Pope","year":"2000"},{"key":"10.2353\/ajpath.2006.050555_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0171-2985(96)80026-X","article-title":"The role of macrophages in chronic arthritis","volume":"195","author":"van den Berg","year":"1996","journal-title":"Immunobiology"},{"key":"10.2353\/ajpath.2006.050555_bib13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2006.050555_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1189\/jlb.68.1.144","article-title":"The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF","volume":"68","author":"Campbell","year":"2000","journal-title":"J Leukoc Biol"},{"key":"10.2353\/ajpath.2006.050555_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/1529-0131(200101)44:1<111::AID-ANR15>3.0.CO;2-1","article-title":"Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor","volume":"44","author":"Yang","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2006.050555_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib17","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1002\/art.10578","article-title":"Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial","volume":"46","author":"Nuki","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2006.050555_bib18","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/art.10308","article-title":"Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes","volume":"46","author":"Genovese","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2006.050555_bib19","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4049\/jimmunol.170.2.838","article-title":"IL-6 and MMP-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts","volume":"170","author":"Perlman","year":"2003","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib20","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.4049\/jimmunol.165.12.7246","article-title":"Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice","volume":"165","author":"Nasu","year":"2000","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/intimm\/13.6.723","article-title":"Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip1) gene into the joints","volume":"13","author":"Nonomura","year":"2001","journal-title":"Int Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(00)81989-3","article-title":"Organ-specific disease provoked by systemic autoimmunity","volume":"87","author":"Kouskoff","year":"1996","journal-title":"Cell"},{"key":"10.2353\/ajpath.2006.050555_bib23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(00)80045-X","article-title":"From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins","volume":"10","author":"Korganow","year":"1999","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2006.050555_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmed.2003.11.004","article-title":"The K\/BxN mouse: a model of human inflammatory arthritis","volume":"10","author":"Ditzel","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.2353\/ajpath.2006.050555_bib25","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/1529-0131(200112)44:12<2899::AID-ART478>3.0.CO;2-X","article-title":"Differential expression pattern of the anti-apoptotic proteins, Bcl-2 and Flip in experimental arthritis","volume":"44","author":"Perlman","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2006.050555_bib26","doi-asserted-by":"crossref","first-page":"7584","DOI":"10.4049\/jimmunol.173.12.7584","article-title":"Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo","volume":"173","author":"Brown","year":"2004","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib27","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","article-title":"TRANCE\/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis","volume":"159","author":"Pettit","year":"2001","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.050555_bib28","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.4049\/jimmunol.169.11.6604","article-title":"The role of Fc\u03b3R signaling in the K\/BxN serum transfer model of arthritis","volume":"169","author":"Corr","year":"2002","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib29","first-page":"1169","article-title":"WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis","volume":"54","author":"el-Deiry","year":"1994","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2006.050555_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00281-003-0131-5","article-title":"The KRN mouse model of inflammatory arthritis","volume":"25","author":"Kyburz","year":"2003","journal-title":"Springer Semin Immunopathol"},{"key":"10.2353\/ajpath.2006.050555_bib31","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/S0002-9440(10)63543-2","article-title":"The inhibitory receptor Fc\u03b3RII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of Fc\u03b3RI\/III but also by efficient clearance and endocytosis of immune complexes","volume":"163","author":"van Lent","year":"2003","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.050555_bib32","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.4049\/jimmunol.172.12.7694","article-title":"Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes","volume":"172","author":"Wipke","year":"2004","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib33","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.4049\/jimmunol.171.9.4913","article-title":"Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis","volume":"171","author":"Nonomura","year":"2003","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib34","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/10480","article-title":"Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis","volume":"5","author":"Taniguchi","year":"1999","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2006.050555_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0022-1759(94)90005-1","article-title":"Markers of mouse macrophage development detected by monoclonal antibodies","volume":"174","author":"Leenen","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.2353\/ajpath.2006.050555_bib36","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1128\/MCB.22.22.8035-8043.2002","article-title":"Inactivation of the F4\/80 glycoprotein in the mouse germ line","volume":"22","author":"Schaller","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2006.050555_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2006.050555_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bcmd.2003.09.003","article-title":"Transplanted ER-MP12hi20\u201358med\/hi myeloid progenitors produce resident macrophages from marrow that are therapeutic for lysosomal storage disease","volume":"32","author":"Soper","year":"2004","journal-title":"Blood Cells Mol Dis"},{"key":"10.2353\/ajpath.2006.050555_bib39","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.4049\/jimmunol.151.11.6389","article-title":"Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen","volume":"151","author":"McCormack","year":"1993","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib40","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.4049\/jimmunol.167.3.1601","article-title":"Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis","volume":"167","author":"Wipke","year":"2001","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib41","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/eji.200526167","article-title":"A crucial role for macrophages in the pathology of K\/BxN serum-induced arthritis","volume":"35","author":"Solomon","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib42","first-page":"1328","article-title":"The major histocompatibility complex class I-like Fc receptor promotes humorally mediated autoimmune disease","volume":"113","author":"Akilesh","year":"2004","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2006.050555_bib43","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.050555_bib44","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1073\/pnas.92.18.8264","article-title":"Decreased atherosclerosis in mice deficient in both macrophage colony- stimulating factor (op) and apolipoprotein E","volume":"92","author":"Smith","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2006.050555_bib45","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1096\/fj.01-0130com","article-title":"The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis","volume":"15","author":"Diez-Juan","year":"2001","journal-title":"FASEB J"},{"key":"10.2353\/ajpath.2006.050555_bib46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.273.5273.359","article-title":"Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation","volume":"273","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.2353\/ajpath.2006.050555_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/embo-reports\/kve008","article-title":"p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal","volume":"2","author":"Zezula","year":"2001","journal-title":"EMBO Rep"},{"key":"10.2353\/ajpath.2006.050555_bib48","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1073\/pnas.92.12.5451","article-title":"Involvement of the cell-cycle inhibitor Cip1\/WAF1 and the E1A-associated p300 chain protein in terminal differentiation","volume":"92","author":"Missero","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2006.050555_bib49","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1128\/MCB.16.4.1335","article-title":"The cyclin-dependent kinase inhibitor p21WAF1 is required for survival of differentiating neuroblastoma cells","volume":"16","author":"Poluha","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2006.050555_bib50","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/sj.leu.2401228","article-title":"p21Cip1\/WAF1 is important for differentiation and survival of U937 cells","volume":"12","author":"Asada","year":"1998","journal-title":"Leukemia"},{"key":"10.2353\/ajpath.2006.050555_bib51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.10.2.142","article-title":"Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937","volume":"10","author":"Liu","year":"1996","journal-title":"Genes & Dev"},{"key":"10.2353\/ajpath.2006.050555_bib52","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1365-2141.2002.03498.x","article-title":"Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (WAF1\/CIP1) and requires iron","volume":"117","author":"Kramer","year":"2002","journal-title":"Br J Haematol"},{"key":"10.2353\/ajpath.2006.050555_bib53","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/eji.200425110","article-title":"Macrophage colony-stimulating factor-, granulocyte-macrophage colony-stimulating factor-, or IL-3-dependent survival of macrophages, but not proliferation, require the expression of p21(Waf1) through the phosphatidylinositol 3-kinase\/Akt pathway","volume":"34","author":"Comalada","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.2353\/ajpath.2006.050555_bib54","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1182\/blood.V98.7.2124","article-title":"Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1)","volume":"98","author":"Xaus","year":"2001","journal-title":"Blood"},{"key":"10.2353\/ajpath.2006.050555_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1074-7613(00)80085-0","article-title":"Interferon gamma induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis","volume":"11","author":"Xaus","year":"1999","journal-title":"Immunity"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010621761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010621761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T22:57:49Z","timestamp":1707692269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010621761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0002944010621761"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2006.050555","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}