{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:39:14Z","timestamp":1790919554457,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 AI058107"],"award-info":[{"award-number":["1R01 AI058107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U19 AI062629"],"award-info":[{"award-number":["1U19 AI062629"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR020143"],"award-info":[{"award-number":["RR020143"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.2353\/ajpath.2006.051330","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T17:19:07Z","timestamp":1156180747000},"page":"433-444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Sepsis and Pathophysiology of Anthrax in a Nonhuman Primate Model"],"prefix":"10.1016","volume":"169","author":[{"given":"Deborah J.","family":"Stearns-Kurosawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florea","family":"Lupu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Fletcher B.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kinasewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2006.051330_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid0706.010604","article-title":"Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States","volume":"7","author":"Jernigan","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"10.2353\/ajpath.2006.051330_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/jama.287.7.869","article-title":"Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant","volume":"287","author":"Freedman","year":"2002","journal-title":"JAMA"},{"key":"10.2353\/ajpath.2006.051330_bib3","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1001\/jama.286.20.2554","article-title":"Death due to bioterrorism-related inhalational anthrax: report of 2 patients","volume":"286","author":"Borio","year":"2001","journal-title":"JAMA"},{"key":"10.2353\/ajpath.2006.051330_bib4","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jama.287.7.863","article-title":"Fatal inhalational anthrax in a 94-year-old Connecticut woman","volume":"287","author":"Barakat","year":"2002","journal-title":"JAMA"},{"key":"10.2353\/ajpath.2006.051330_bib5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jama.287.7.858","article-title":"Fatal inhalational anthrax with unknown source of exposure in a 61-year-old woman in New York City","volume":"287","author":"Mina","year":"2002","journal-title":"JAMA"},{"key":"10.2353\/ajpath.2006.051330_bib6","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa012948","article-title":"Index case of fatal inhalational anthrax due to bioterrorism in the United States","volume":"345","author":"Bush","year":"2001","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2006.051330_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature01586","article-title":"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria","volume":"423","author":"Read","year":"2003","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nature02763","article-title":"Crystal structure of a complex between anthrax toxin and its host cell receptor","volume":"430","author":"Santelli","year":"2004","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","article-title":"Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib10","doi-asserted-by":"crossref","first-page":"23349","DOI":"10.1074\/jbc.M401292200","article-title":"Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen","volume":"279","author":"Wigelsworth","year":"2004","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2006.051330_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1128\/iai.49.2.291-297.1985","article-title":"Demonstration of a capsule plasmid in Bacillus anthracis","volume":"49","author":"Green","year":"1985","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.051330_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/iai.39.1.371-376.1983","article-title":"Evidence for plasmid-mediated toxin production in Bacillus anthracis","volume":"39","author":"Mikesell","year":"1983","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.051330_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.emboj.7600495","article-title":"Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax","volume":"24","author":"Drysdale","year":"2005","journal-title":"EMBO J"},{"key":"10.2353\/ajpath.2006.051330_bib15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1365-2958.1995.tb02340.x","article-title":"The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence","volume":"16","author":"Dai","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.2353\/ajpath.2006.051330_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"Collier","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.2353\/ajpath.2006.051330_bib17","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.2353\/ajpath.2006.051330_bib18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0002-9440(10)63697-8","article-title":"Pathology and pathogenesis of bioterrorism-related inhalational anthrax","volume":"163","author":"Guarner","year":"2003","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.051330_bib19","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1073\/pnas.90.6.2291","article-title":"Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979","volume":"90","author":"Abramova","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2006.051330_bib20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.7973702","article-title":"The Sverdlovsk anthrax outbreak of 1979","volume":"266","author":"Meselson","year":"1994","journal-title":"Science"},{"key":"10.2353\/ajpath.2006.051330_bib21","first-page":"416","article-title":"Pathology of experimental respiratory anthrax in Macaca mulatta","volume":"44","author":"Gleiser","year":"1963","journal-title":"Br J Exp Pathol"},{"key":"10.2353\/ajpath.2006.051330_bib22","first-page":"1055","article-title":"Experimental inhalation anthrax in the chimpanzee","volume":"35","author":"Albrink","year":"1959","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.051330_bib23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/infdis\/115.5.481","article-title":"Role of the lymphatics in the pathogenesis of anthrax","volume":"115","author":"Lincoln","year":"1965","journal-title":"J Infect Dis"},{"key":"10.2353\/ajpath.2006.051330_bib24","first-page":"691","article-title":"Pathology of experimental inhalation anthrax in the rhesus monkey","volume":"73","author":"Fritz","year":"1995","journal-title":"Lab Invest"},{"key":"10.2353\/ajpath.2006.051330_bib25","first-page":"R699","article-title":"Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats","volume":"286","author":"Cui","year":"2004","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2006.051330_bib26","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.0502159102","article-title":"Anthrax lethal factor inhibition","volume":"102","author":"Shoop","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2006.051330_bib27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","article-title":"Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice","volume":"112","author":"Moayeri","year":"2003","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2006.051330_bib28","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/00003246-200107001-00026","article-title":"Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants","volume":"29","author":"Taylor","year":"2001","journal-title":"Crit Care Med"},{"key":"10.2353\/ajpath.2006.051330_bib29","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00003246-200009001-00004","volume":"28","author":"Taylor","year":"2000","journal-title":"Crit Care Med"},{"key":"10.2353\/ajpath.2006.051330_bib30","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1172\/JCI112902","article-title":"Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon","volume":"79","author":"Taylor","year":"1987","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2006.051330_bib31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","article-title":"Efficacy and safety of recombinant human activated protein C for severe sepsis","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2006.051330_bib32","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/IAI.72.8.4801-4809.2004","article-title":"Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility","volume":"72","author":"Lyons","year":"2004","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.051330_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0076-6879(88)65019-1","article-title":"Production and purification of anthrax toxin","volume":"165","author":"Leppla","year":"1988","journal-title":"Methods Enzymol"},{"key":"10.2353\/ajpath.2006.051330_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/01.shk.0000068326.68761.34","article-title":"Reduced neutrophil CD10 expression in non-human primates and humans after in vivo challenge with E. coli or lipopolysaccharide","volume":"20","author":"Kaneko","year":"2003","journal-title":"Shock"},{"key":"10.2353\/ajpath.2006.051330_bib35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0002-9440(10)65380-1","article-title":"Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1","volume":"154","author":"Taylor","year":"1999","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.051330_bib36","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1182\/blood.V91.5.1609","article-title":"Active site inhibited factor VIIa (DEGR VIIa) attenuates the coagulant and interleukin-6 and -8, but not tumor necrosis factor, responses of the baboon to LD100 Escherichia coli","volume":"91","author":"Taylor","year":"1998","journal-title":"Blood"},{"key":"10.2353\/ajpath.2006.051330_bib37","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1182\/blood.V95.5.1680.005k33_1680_1686","article-title":"The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis","volume":"95","author":"Taylor","year":"2000","journal-title":"Blood"},{"key":"10.2353\/ajpath.2006.051330_bib38","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1055\/s-0037-1615118","article-title":"Attenuation of tissue thrombosis and hemorrhage by ala-TFPI does not account for its protection against E. coli\u2014a comparative study of treated and untreated non-surviving baboons challenged with LD100 E. coli","volume":"79","author":"Randolph","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.2353\/ajpath.2006.051330_bib39","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1161\/01.ATV.14.9.1438","article-title":"Expression of LDL receptor-related protein\/alpha 2-macroglobulin receptor in human normal and atherosclerotic arteries","volume":"14","author":"Lupu","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.2353\/ajpath.2006.051330_bib40","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/bi0119518","article-title":"PA63 channel of anthrax toxin: an extended beta-barrel","volume":"41","author":"Nassi","year":"2002","journal-title":"Biochemistry"},{"key":"10.2353\/ajpath.2006.051330_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/B:THRO.0000014592.27892.11","article-title":"Sepsis and disseminated intravascular coagulation","volume":"16","author":"Levi","year":"2003","journal-title":"J Thromb Thrombolysis"},{"key":"10.2353\/ajpath.2006.051330_bib42","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/00003246-200107001-00018","article-title":"Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation","volume":"29","author":"Esmon","year":"2001","journal-title":"Crit Care Med"},{"key":"10.2353\/ajpath.2006.051330_bib43","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00003246-200009001-00011","article-title":"Protein C levels as a prognostic indicator of outcome in sepsis and related diseases","volume":"28","author":"Fisher","year":"2000","journal-title":"Crit Care Med"},{"key":"10.2353\/ajpath.2006.051330_bib44","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.160.12.5936","article-title":"Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10","volume":"160","author":"Aste-Amezaga","year":"1998","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.051330_bib45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1749-6632.1996.tb52690.x","article-title":"The release of interleukin-12 in Escherichia coli-induced lethal and sublethal primate sepsis","volume":"795","author":"Jansen","year":"1996","journal-title":"Ann NY Acad Sci"},{"key":"10.2353\/ajpath.2006.051330_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1532\/IJH97.03167","article-title":"Tissue factor: a key molecule in hemostatic and nonhemostatic systems","volume":"79","author":"Morrissey","year":"2004","journal-title":"Int J Hematol"},{"key":"10.2353\/ajpath.2006.051330_bib47","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1055\/s-0038-1653884","article-title":"Sites of tissue factor pathway inhibitor (TFPI) and tissue factor expression under physiologic and pathologic conditions. On behalf of the Subcommittee on Tissue factor Pathway Inhibitor (TFPI) of the Scientific and Standardization Committee of the ISTH","volume":"73","author":"Osterud","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.2353\/ajpath.2006.051330_bib48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/01.LAB.0000080599.43791.01","article-title":"Pathology of inhalation anthrax in cynomolgus monkeys (Macaca fascicularis)","volume":"83","author":"Vasconcelos","year":"2003","journal-title":"Lab Invest"},{"key":"10.2353\/ajpath.2006.051330_bib49","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature02722","article-title":"Anthrax kills wild chimpanzees in a tropical rainforest","volume":"430","author":"Leendertz","year":"2004","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib50","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/IAI.72.8.4801-4809.2004","article-title":"Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility","volume":"72","author":"Lyons","year":"2004","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.051330_bib51","first-page":"L887","article-title":"Toll-like receptors: function and roles in lung disease","volume":"286","author":"Basu","year":"2004","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2006.051330_bib52","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature02405","article-title":"The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4","volume":"428","author":"Hsu","year":"2004","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib53","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1084\/jem.20041215","article-title":"Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists","volume":"200","author":"Park","year":"2004","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2006.051330_bib54","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.0105-2896.2004.00214.x","article-title":"IL-12 and IL-23: master regulators of innate and adaptive immunity","volume":"202","author":"Langrish","year":"2004","journal-title":"Immunol Rev"},{"key":"10.2353\/ajpath.2006.051330_bib55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0888-7543(05)80283-6","article-title":"Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5","volume":"14","author":"Sieburth","year":"1992","journal-title":"Genomics"},{"key":"10.2353\/ajpath.2006.051330_bib56","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.160.12.5936","article-title":"Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10","volume":"160","author":"Aste-Amezaga","year":"1998","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.051330_bib57","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1006\/cyto.1997.0215","article-title":"Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease","volume":"9","author":"Hazelzet","year":"1997","journal-title":"Cytokine"},{"key":"10.2353\/ajpath.2006.051330_bib58","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1191\/0961203302lu213oa","article-title":"Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity","volume":"11","author":"Lauwerys","year":"2002","journal-title":"Lupus"},{"key":"10.2353\/ajpath.2006.051330_bib59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4049\/jimmunol.154.1.116","article-title":"Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity","volume":"154","author":"Ling","year":"1995","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.051330_bib60","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2006.051330_bib61","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1521-4141(200202)32:2<541::AID-IMMU541>3.0.CO;2-P","article-title":"Cytokine induction by purified lipoteichoic acids from various bacterial species\u2014role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release","volume":"32","author":"Hermann","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.2353\/ajpath.2006.051330_bib62","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01794","article-title":"Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin","volume":"424","author":"Agrawal","year":"2003","journal-title":"Nature"},{"key":"10.2353\/ajpath.2006.051330_bib63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1128\/iai.61.1.245-252.1993","article-title":"Characterization of macrophage sensitivity and resistance to anthrax lethal toxin","volume":"61","author":"Friedlander","year":"1993","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2006.051330_bib64","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci"},{"key":"10.2353\/ajpath.2006.051330_bib65","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.tibs.2003.10.006","article-title":"NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?","volume":"28","author":"Schopfer","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"10.2353\/ajpath.2006.051330_bib66","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.164.10.5439","article-title":"Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis","volume":"164","author":"Frevert","year":"2000","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2006.051330_bib67","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1462-5822.2005.00539.x","article-title":"Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity","volume":"7","author":"Voth","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.2353\/ajpath.2006.051330_bib68","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9440(10)61218-7","article-title":"Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice","volume":"167","author":"Firoved","year":"2005","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2006.051330_bib69","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1365-2672.1999.00881.x","article-title":"The capsule of bacillus anthracis, a review","volume":"87","author":"Ezzell","year":"1999","journal-title":"J Appl Microbiol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010627277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010627277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:16:32Z","timestamp":1757600192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010627277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0002944010627277"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2006.051330","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sepsis and Pathophysiology of Anthrax in a Nonhuman Primate Model","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2006.051330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}