{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:41:49Z","timestamp":1791322909988,"version":"4.3.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.2353\/ajpath.2007.060583","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T20:31:52Z","timestamp":1172262712000},"page":"1003-1017","source":"Crossref","is-referenced-by-count":61,"title":["Clostridium sordellii Lethal Toxin Kills Mice by Inducing a Major Increase in Lung Vascular Permeability"],"prefix":"10.1016","volume":"170","author":[{"given":"Blandine","family":"Geny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huot","family":"Khun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fitting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Zarantonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Mazuet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Cayet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Szatanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Prevost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Cavaillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Huerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel R.","family":"Popoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2007.060583_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0163-4453(96)93100-X","article-title":"Clostridium sordellii bacteraemia","volume":"33","author":"Cunniffe","year":"1996","journal-title":"J Infect"},{"key":"10.2353\/ajpath.2007.060583_bib2","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1086\/383471","article-title":"Outbreak of necrotizing fascillitis due to Clostridium sordellii among black-tar heroin users","volume":"38","author":"Kimura","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.2353\/ajpath.2007.060583_bib3","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1056\/NEJMoa051620","article-title":"Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion","volume":"353","author":"Fischer","year":"2005","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2007.060583_bib4","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1345\/aph.1G189","article-title":"Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii","volume":"39","author":"Miech","year":"2005","journal-title":"Ann Pharmacother"},{"key":"10.2353\/ajpath.2007.060583_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/jcp.50.3.259","article-title":"A fatal postpartum Clostridium sordellii associated toxic shock syndrome","volume":"50","author":"Bitti","year":"1997","journal-title":"J Clin Pathol"},{"key":"10.2353\/ajpath.2007.060583_bib6","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1034\/j.1600-0412.2000.0790121134.x","article-title":"Postpartum Clostridium sordellii infection associated with fatal toxic shock syndrome","volume":"79","author":"R\u00f8rbye","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.2353\/ajpath.2007.060583_bib7","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1086\/344464","article-title":"Toxic shock syndrome due to Clostridium sordellii: a dramatic postpartum and postabortion disease","volume":"35","author":"Sinave","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.2353\/ajpath.2007.060583_bib8","first-page":"724","article-title":"Clostridium sordellii toxic shock syndrome after medical abortion with mifepristone and intravaginal miprostol\u2014United States and Canada 2001\u20132005","volume":"54","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.2353\/ajpath.2007.060583_bib9","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/jcp.53.9.709","article-title":"The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature","volume":"53","author":"Abdulla","year":"2000","journal-title":"J Clin Pathol"},{"key":"10.2353\/ajpath.2007.060583_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1086\/313686","article-title":"Polymicrobial septic arthritis due to Clostridium species: case report and review","volume":"30","author":"Gredlein","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.2353\/ajpath.2007.060583_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/vr.111.1.22-a","article-title":"Clostridium sordellii in lambs","volume":"111","author":"Richards","year":"1982","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/vr.112.1.5","article-title":"Bacteria in enteric lesions of cattle","volume":"112","author":"Al-Mashat","year":"1983","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1136\/vr.114.13.324","article-title":"Bacteriological examination in enterotoxaemia of sheep and lamb","volume":"114","author":"Popoff","year":"1984","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/vr.142.16.417","article-title":"Sudden death in sheep associated with Clostridium sordellii","volume":"142","author":"Lewis","year":"1998","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/vr.112.1.19","article-title":"Clostridium sordellii in enteritis in an adult sheep","volume":"112","author":"Al-Mashat","year":"1983","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib16","first-page":"340","article-title":"Sudden death in periparturient sheep associated with Clostridium sordellii","volume":"153","author":"Clark","year":"2003","journal-title":"Vet Rec"},{"key":"10.2353\/ajpath.2007.060583_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1099\/00222615-2-1-37","article-title":"The toxins responsible for the lesions of Clostridium sordellii gas gangrene","volume":"2","author":"Arseculeratne","year":"1969","journal-title":"J Med Microbiol"},{"key":"10.2353\/ajpath.2007.060583_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/IAI.55.1.35-43.1987","article-title":"Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin","volume":"55","author":"Popoff","year":"1987","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2007.060583_bib19","first-page":"127","article-title":"Bacterial toxins: lethal amounts","volume":"8","author":"Gill","year":"1987"},{"key":"10.2353\/ajpath.2007.060583_bib20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0041-0101(91)90224-F","article-title":"A comparative biochemical, pharmacological and immunological study of Clostridium novyi alpha-toxin, C difficile toxin B and C sordellii lethal toxin","volume":"29","author":"Bette","year":"1991","journal-title":"Toxicon"},{"key":"10.2353\/ajpath.2007.060583_bib21","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1073\/pnas.91.11.4960","article-title":"Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes","volume":"91","author":"Thelen","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.060583_bib22","series-title":"In Bacterial Protein Toxins","first-page":"307","article-title":"Molecular mechanism of action of the large clostridial cytotoxins","author":"Just","year":"2000"},{"key":"10.2353\/ajpath.2007.060583_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/bbrc.1996.1470","article-title":"The Ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin","volume":"227","author":"Hofmann","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2007.060583_bib24","doi-asserted-by":"crossref","first-page":"10149","DOI":"10.1074\/jbc.271.17.10149","article-title":"Inactivation of Ras by Clostridium sordellii lethal toxin-catalysed glucosylation","volume":"271","author":"Just","year":"1996","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060583_bib25","doi-asserted-by":"crossref","first-page":"10217","DOI":"10.1074\/jbc.271.17.10217","article-title":"Ras, Rap, and Rac small GTP-binding proteins are targets for the Clostridium sordellii lethal toxin glucosylation","volume":"271","author":"Popoff","year":"1996","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060583_bib26","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1523\/JNEUROSCI.22-18-07968.2002","article-title":"Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites","volume":"22","author":"Humeau","year":"2002","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2007.060583_bib27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0882-4010(87)90073-8","article-title":"Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related","volume":"2","author":"von Eichel-Streiber","year":"1987","journal-title":"Microb Pathog"},{"key":"10.2353\/ajpath.2007.060583_bib28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH619>3.0.CO;2-H","article-title":"Outbred mice with long-term Helicobacter felis infection develop both gastric lymphoid tissue and glandular hyperplastic lesions","volume":"191","author":"Ferrero","year":"2000","journal-title":"J Pathol"},{"key":"10.2353\/ajpath.2007.060583_bib29","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/IAI.72.6.3120-3128.2004","article-title":"Degeneration and regeneration of murine skeletal neuromuscular junctions after intramuscular injection with a sublethal dose of Clostridium sordellii lethal toxin","volume":"72","author":"Barbier","year":"2004","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2007.060583_bib30","series-title":"Pathologic Basis of Disease","first-page":"93","article-title":"Hemodynamic disorders, thrombosis and shock","author":"Robbins","year":"1994"},{"key":"10.2353\/ajpath.2007.060583_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.CIR.95.1.163","article-title":"Elevations of cardiac troponin I associated with myocarditis","volume":"95","author":"Smith","year":"1997","journal-title":"Circulation"},{"key":"10.2353\/ajpath.2007.060583_bib32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1046\/j.1462-5822.2003.00309.x","article-title":"Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of the mitochondrial homeostasis in HL-60 cells","volume":"5","author":"Petit","year":"2003","journal-title":"Cell Microbiol"},{"key":"10.2353\/ajpath.2007.060583_bib33","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0041-0101(01)00156-8","article-title":"Superantigen bacterial toxins: state of the art","volume":"39","author":"M\u00fcller-Alouf","year":"2001","journal-title":"Toxicon"},{"key":"10.2353\/ajpath.2007.060583_bib34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0016-5085(87)91014-6","article-title":"Differential effects of Clostridium difficile toxins A and B on rabbit ileum","volume":"93","author":"Triadafilopoulos","year":"1987","journal-title":"Gastroenterology"},{"key":"10.2353\/ajpath.2007.060583_bib35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/gut.38.3.337","article-title":"Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment","volume":"38","author":"Mahida","year":"1996","journal-title":"Gut"},{"key":"10.2353\/ajpath.2007.060583_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0016-5085(03)00902-8","article-title":"Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine","volume":"125","author":"Savidge","year":"2003","journal-title":"Gastroenterology"},{"key":"10.2353\/ajpath.2007.060583_bib37","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1073\/pnas.0402693101","article-title":"Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation","volume":"101","author":"Anton","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.060583_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1749-6632.2000.tb05263.x","article-title":"Effects of Clostridium difficile toxins on epithelial cell barrier","volume":"915","author":"Pothoulakis","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.2353\/ajpath.2007.060583_bib39","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI7545","article-title":"p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production and enteritis","volume":"105","author":"Warny","year":"2000","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2007.060583_bib40","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1053\/gast.2002.32386","article-title":"Clostridium difficile toxin A human colonocyte IL-8 release via mitochondrial oxygen radical generation","volume":"122","author":"He","year":"2002","journal-title":"Gastroenterology"},{"key":"10.2353\/ajpath.2007.060583_bib41","doi-asserted-by":"crossref","first-page":"21237","DOI":"10.1074\/jbc.M413842200","article-title":"Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK","volume":"280","author":"Kim","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060583_bib42","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.1073\/pnas.90.21.10198","article-title":"On the role of macrophages in anthrax","volume":"90","author":"Hanna","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.060583_bib43","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2007.060583_bib44","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.4049\/jimmunol.166.10.6301","article-title":"Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats","volume":"166","author":"Pittet","year":"2001","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2007.060583_bib45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1164\/ajrccm.163.2.2004187","article-title":"Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome","volume":"163","author":"Sittipunt","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.2353\/ajpath.2007.060583_bib46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1164\/ajrccm.163.1.2005068","article-title":"Increased levels on nitrate and surfactant protein A nitration in pulmonary edema fluid of patients with acute lung injury","volume":"163","author":"Zhu","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.2353\/ajpath.2007.060583_bib47","first-page":"L259","article-title":"Increased iNOS activity is essential for pulmonary epithelial tight junctions dysfunction in endotoxemic mice","volume":"286","author":"Han","year":"2005","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2007.060583_bib48","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0002-9378(89)90768-0","article-title":"Maternal deaths associated with Clostridium sordellii infection","volume":"161","author":"McGregor","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.2353\/ajpath.2007.060583_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1155\/S1064744996000087","article-title":"Clostridium sordellii toxic shock syndrome: a case report and review of the literature","volume":"4","author":"Sosolik","year":"1996","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.2353\/ajpath.2007.060583_bib50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3480241","article-title":"Rho GTPases and their effector proteins","volume":"348","author":"Bishop","year":"2000","journal-title":"Biochem J"},{"key":"10.2353\/ajpath.2007.060583_bib51","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1091\/mbc.9.9.2639","article-title":"Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function","volume":"9","author":"Vouret-Craviari","year":"1998","journal-title":"Mol Biol Cell"},{"key":"10.2353\/ajpath.2007.060583_bib52","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/(SICI)1097-4652(199807)176:1<150::AID-JCP17>3.0.CO;2-B","article-title":"Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells","volume":"176","author":"W\u00f3jciak-Stothard","year":"1998","journal-title":"J Cell Physiol"},{"key":"10.2353\/ajpath.2007.060583_bib53","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1128\/IAI.67.6.3002-3008.1999","article-title":"Effect of cytotoxic necrotizing factor1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers","volume":"67","author":"Vouret-Craviari","year":"1999","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2007.060583_bib54","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1242\/jcs.114.7.1343","article-title":"Rho and Rac but not Cdc42 regulate endothelial cell permeability","volume":"114","author":"W\u00f3jciak-Stothard","year":"2001","journal-title":"J Cell Sci"},{"key":"10.2353\/ajpath.2007.060583_bib55","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.2001.013117","article-title":"Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice","volume":"539","author":"Adamson","year":"2002","journal-title":"J Physiol"},{"key":"10.2353\/ajpath.2007.060583_bib56","first-page":"H394","article-title":"Requirement of Rac activity for maintenance of capillary barrier properties","volume":"286","author":"Waschke","year":"2004","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2007.060583_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.142.1.101","article-title":"Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases","volume":"142","author":"Jou","year":"1998","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2007.060583_bib58","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0955-0674(99)00014-9","article-title":"Regulation of cadherin mediated cell-cell adhesion by Rho family GTPases","volume":"11","author":"Kaibuchi","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"10.2353\/ajpath.2007.060583_bib59","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1462-5822.2006.00687.x","article-title":"Modification of epithelial cell barrier permeability and intercellular junctions by Clostridium sordellii lethal toxin","volume":"8","author":"Boehm","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.2353\/ajpath.2007.060583_bib60","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(00)80226-3","article-title":"Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by ras","volume":"89","author":"Rodriguez-Viciana","year":"1997","journal-title":"Cell"},{"key":"10.2353\/ajpath.2007.060583_bib61","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1093\/emboj\/17.23.6776","article-title":"All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral","volume":"17","author":"Bos","year":"1998","journal-title":"EMBO J"},{"key":"10.2353\/ajpath.2007.060583_bib62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-5793(01)02251-7","article-title":"The Ras GDP\/GTP cycle is regulated by oxidizing agents at the level of Ras regulators and effectors","volume":"492","author":"Accorsi","year":"2001","journal-title":"FEBS Lett"},{"key":"10.2353\/ajpath.2007.060583_bib63","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/sj.onc.1202174","article-title":"Increasing complexity of Ras signaling","volume":"17","author":"Campbell","year":"1998","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2007.060583_bib64","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1128\/MCB.24.15.6690-6700.2004","article-title":"Rap1 regulates the formation of E-cadherin-based cell-cell contacts","volume":"24","author":"Hogan","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2007.060583_bib65","doi-asserted-by":"crossref","first-page":"35127","DOI":"10.1074\/jbc.M404917200","article-title":"Rap1 regulates E-cadherin-mediated cell-cell adhesion","volume":"279","author":"Price","year":"2004","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060583_bib66","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1126\/science.1073163","article-title":"Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition","volume":"297","author":"Park","year":"2002","journal-title":"Science"},{"key":"10.2353\/ajpath.2007.060583_bib67","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","article-title":"Bacillus anthracis lethal toxin induces TNF\u03b1-independent hypoxia-mediated toxicity in mice","volume":"112","author":"Moayeri","year":"2003","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2007.060583_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-5793(99)01502-1","article-title":"Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS\/INF\u03b3-induced release of NO and TNF\u03b1","volume":"462","author":"Pellizzari","year":"1999","journal-title":"FEBS Lett"},{"key":"10.2353\/ajpath.2007.060583_bib69","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1998.9040","article-title":"Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine\/threonine phosphorylation of MAPKs in cultured macro-phages","volume":"248","author":"Vitale","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2007.060583_bib70","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9440(10)61218-7","article-title":"Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice","volume":"167","author":"Firoved","year":"2005","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2007.060583_bib71","first-page":"F433","article-title":"The transport barrier in intraperitoneal therapy","volume":"288","author":"Flessner","year":"2005","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2007.060583_bib72","doi-asserted-by":"crossref","first-page":"44535","DOI":"10.1074\/jbc.M307540200","article-title":"Cellular uptake of Clostridium difficile toxin B","volume":"278","author":"Pfeifer","year":"2003","journal-title":"J Biol Chem"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010609200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010609200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T06:10:28Z","timestamp":1707631828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010609200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0002944010609200"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2007.060583","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}