{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:57:52Z","timestamp":1791338272404,"version":"4.3.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.2353\/ajpath.2007.060975","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T19:34:05Z","timestamp":1176492845000},"page":"2112-2121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Down-Regulation of WAVE3, a Metastasis Promoter Gene, Inhibits Invasion and Metastasis of Breast Cancer Cells"],"prefix":"10.1016","volume":"170","author":[{"given":"Khalid","family":"Sossey-Alaoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfiya","family":"Safina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiurong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Bakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Cowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2007.060975_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.2353\/ajpath.2007.060975_bib2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrc1075","article-title":"Tumour-cell invasion and migration: diversity and escape mechanisms","volume":"3","author":"Friedl","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.2353\/ajpath.2007.060975_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1385\/IJGC:31:1-3:5","article-title":"Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation?","volume":"31","author":"Billadeau","year":"2002","journal-title":"Int J Gastrointest Cancer"},{"key":"10.2353\/ajpath.2007.060975_bib4","first-page":"6906","article-title":"Cortactin potentiates bone metastasis of breast cancer cells","volume":"61","author":"Li","year":"2001","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2007.060975_bib5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/375338a0","article-title":"A role for Rac in Tiam1-induced membrane ruffling and invasion","volume":"375","author":"Michiels","year":"1995","journal-title":"Nature"},{"key":"10.2353\/ajpath.2007.060975_bib6","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1073\/pnas.1232344100","article-title":"A role for LIM kinase in cancer invasion","volume":"100","author":"Yoshioka","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.060975_bib7","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1067\/mva.2002.123094","article-title":"Rho and basic fibroblast growth factor involvement in centrosome redistribution and actin microfilament remodeling during early endothelial wound repair","volume":"35","author":"Lee","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.2353\/ajpath.2007.060975_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0074-7696(03)29006-9","article-title":"Regulation of cortical actin networks in cell migration","volume":"229","author":"Suetsugu","year":"2003","journal-title":"Int Rev Cytol"},{"key":"10.2353\/ajpath.2007.060975_bib9","doi-asserted-by":"crossref","first-page":"21748","DOI":"10.1074\/jbc.M500503200","article-title":"WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase","volume":"280","author":"Sossey-Alaoui","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060975_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.yexcr.2005.04.011","article-title":"WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression","volume":"308","author":"Sossey-Alaoui","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.2353\/ajpath.2007.060975_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments","volume":"112","author":"Pollard","year":"2003","journal-title":"Cell"},{"key":"10.2353\/ajpath.2007.060975_bib12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","article-title":"WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement","volume":"114","author":"Takenawa","year":"2001","journal-title":"J Cell Sci"},{"key":"10.2353\/ajpath.2007.060975_bib13","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1038\/sj.onc.1205734","article-title":"WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma","volume":"21","author":"Sossey-Alaoui","year":"2002","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2007.060975_bib14","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/sj.onc.1210046","article-title":"ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells","volume":"26","author":"Safina","year":"2007","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2007.060975_bib15","first-page":"801","article-title":"Tissue culture studies on pleural effusions from breast carcinoma patients","volume":"34","author":"Cailleau","year":"1974","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2007.060975_bib16","doi-asserted-by":"crossref","first-page":"R819","DOI":"10.1186\/bcr1292","article-title":"Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment","volume":"7","author":"Richert","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.2353\/ajpath.2007.060975_bib17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/sj.onc.1208177","article-title":"Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells","volume":"24","author":"Kurisu","year":"2005","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2007.060975_bib18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck","volume":"418","author":"Eden","year":"2002","journal-title":"Nature"},{"key":"10.2353\/ajpath.2007.060975_bib19","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1073\/pnas.0400628101","article-title":"Purification and architecture of the ubiquitous Wave complex","volume":"101","author":"Gautreau","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.060975_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncb1105","article-title":"Abi1 is essential for the formation and activation of a WAVE2 signalling complex","volume":"6","author":"Innocenti","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.2353\/ajpath.2007.060975_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1534-5807(03)00297-1","article-title":"Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration","volume":"5","author":"Suetsugu","year":"2003","journal-title":"Dev Cell"},{"key":"10.2353\/ajpath.2007.060975_bib22","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1093\/emboj\/cdg350","article-title":"WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility","volume":"22","author":"Yan","year":"2003","journal-title":"EMBO J"},{"key":"10.2353\/ajpath.2007.060975_bib23","doi-asserted-by":"crossref","first-page":"27605","DOI":"10.1074\/jbc.274.39.27605","article-title":"Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling","volume":"274","author":"Miki","year":"1999","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060975_bib24","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0092-8674(05)80018-2","article-title":"The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK\/SAPK signaling pathway","volume":"81","author":"Coso","year":"1995","journal-title":"Cell"},{"key":"10.2353\/ajpath.2007.060975_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0092-8674(05)80019-4","article-title":"Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs","volume":"81","author":"Minden","year":"1995","journal-title":"Cell"},{"key":"10.2353\/ajpath.2007.060975_bib26","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1242\/jcs.115.15.3193","article-title":"p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration","volume":"115","author":"Bakin","year":"2002","journal-title":"J Cell Sci"},{"key":"10.2353\/ajpath.2007.060975_bib27","doi-asserted-by":"crossref","first-page":"23934","DOI":"10.1074\/jbc.270.41.23934","article-title":"Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1","volume":"270","author":"Zhang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2007.060975_bib28","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.biocel.2004.01.024","article-title":"The actin cytoskeleton in normal and pathological cell motility","volume":"36","author":"Lambrechts","year":"2004","journal-title":"Int J Biochem Cell Biol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010614186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010614186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T01:04:06Z","timestamp":1723251846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010614186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0002944010614186"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2007.060975","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-Regulation of WAVE3, a Metastasis Promoter Gene, Inhibits Invasion and Metastasis of Breast Cancer Cells","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2007.060975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}