{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:19:55Z","timestamp":1791404395850,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014182","name":"McCune Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG17586"],"award-info":[{"award-number":["AG17586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG16976"],"award-info":[{"award-number":["AG16976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG05681"],"award-info":[{"award-number":["AG05681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG13854"],"award-info":[{"award-number":["AG13854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG03991"],"award-info":[{"award-number":["AG03991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG10124"],"award-info":[{"award-number":["AG10124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG12300"],"award-info":[{"award-number":["AG12300"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["74580"],"award-info":[{"award-number":["74580"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.2353\/ajpath.2007.070182","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T10:26:38Z","timestamp":1179570398000},"page":"227-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":500,"title":["TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions"],"prefix":"10.1016","volume":"171","author":[{"given":"Nigel J.","family":"Cairns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen H.","family":"Bigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida E.","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Troost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo J.","family":"Hatanpaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Foong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Taylor-Reinwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Paulsmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Strider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gitcho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.-Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.A.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2007.070182_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1749-6632.2000.tb06904.x","article-title":"Classification and description of frontotemporal dementias","volume":"920","author":"Neary","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.2353\/ajpath.2007.070182_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/jnnp.53.1.23","article-title":"Frontal lobe dementia and motor neuron disease","volume":"53","author":"Neary","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.2353\/ajpath.2007.070182_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00401-004-0900-9","article-title":"Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration","volume":"108","author":"Lipton","year":"2004","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.2353\/ajpath.2007.070182_bib4","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/emboj\/20.7.1774","article-title":"Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping","volume":"20","author":"Buratti","year":"2001","journal-title":"EMBO J"},{"key":"10.2353\/ajpath.2007.070182_bib5","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1086\/420978","article-title":"Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance","volume":"74","author":"Buratti","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.2353\/ajpath.2007.070182_bib6","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1093\/nar\/gki897","article-title":"Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene","volume":"33","author":"Mercado","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2007.070182_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2007.070182_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.2353\/ajpath.2007.070182_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00401-006-0189-y","article-title":"Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43","volume":"113","author":"Davidson","year":"2007","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.2353\/ajpath.2007.070182_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/nen.0b013e31803020b9","article-title":"TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP mutations","volume":"66","author":"Neumann","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/01.jnen.0000248554.45456.58","article-title":"TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions","volume":"66","author":"Neumann","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s004010000346","article-title":"Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions","volume":"102","author":"Woulfe","year":"2001","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.2353\/ajpath.2007.070182_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00005072-200606000-00005","article-title":"Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations","volume":"65","author":"Forman","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2353\/ajpath.2006.060438","article-title":"Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies","volume":"169","author":"Sampathu","year":"2006","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2007.070182_bib15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.2353\/ajpath.2007.070182_bib16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.2353\/ajpath.2007.070182_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ana.20963","article-title":"HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin","volume":"60","author":"Mukherjee","year":"2006","journal-title":"Ann Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib18","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awl271","article-title":"The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene","volume":"129","author":"Mackenzie","year":"2006","journal-title":"Brain"},{"key":"10.2353\/ajpath.2007.070182_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WAD.0b013e31803083f2","article-title":"Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation","volume":"21","author":"Behrens","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.2353\/ajpath.2007.070182_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2007.070182_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jsb.2003.11.014","article-title":"Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions","volume":"146","author":"Wang","year":"2004","journal-title":"J Struct Biol"},{"key":"10.2353\/ajpath.2007.070182_bib22","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2007.070182_bib23","first-page":"S43","article-title":"Ubiquitin-positive inclusions in frontotemporal dementia linked to chromosome 3 (FTD-3)","volume":"16","author":"Holm","year":"2006","journal-title":"Brain Pathol"},{"key":"10.2353\/ajpath.2007.070182_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1212\/01.wnl.0000200048.53766.b4","article-title":"A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia","volume":"66","author":"Morita","year":"2006","journal-title":"Neurology"},{"key":"10.2353\/ajpath.2007.070182_bib25","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/brain\/awl030","article-title":"Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3","volume":"129","author":"Vance","year":"2006","journal-title":"Brain"},{"key":"10.2353\/ajpath.2007.070182_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2377-6-44","article-title":"Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD","volume":"6","author":"Momeni","year":"2006","journal-title":"BMC Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib27","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1001\/archneur.58.11.1803","article-title":"Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease","volume":"58","author":"McKhann","year":"2001","journal-title":"Arch Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib28","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/jnen\/61.11.935","article-title":"Office of Rare Diseases neuropathologic criteria for corticobasal degeneration","volume":"61","author":"Dickson","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Suppl","key":"10.2353\/ajpath.2007.070182_bib29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0022-510X(94)90191-0","volume":"124","author":"Brooks","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.2353\/ajpath.2007.070182_bib30","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1093\/hmg\/ddl241","article-title":"Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration","volume":"15","author":"Gass","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.2353\/ajpath.2007.070182_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/jnen\/61.6.547","article-title":"Argyrophilic grain disease is a sporadic 4-repeat tauopathy","volume":"61","author":"Togo","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib32","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1212\/01.WNL.0000139809.16817.DD","article-title":"Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease","volume":"63","author":"Cairns","year":"2004","journal-title":"Neurology"},{"key":"10.2353\/ajpath.2007.070182_bib33","first-page":"1","article-title":"Hereditary diffuse leucoencephalopathy with spheroids","volume":"314","author":"Axelsson","year":"1984","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"10.2353\/ajpath.2007.070182_bib34","series-title":"Pick's Disease and Pick Complex","first-page":"211","article-title":"The pathology of pick complex","author":"Munoz","year":"1998"},{"key":"10.2353\/ajpath.2007.070182_bib35","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.2353\/ajpath.2007.070182_bib36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.2353\/ajpath.2007.070182_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archneur.56.1.33","article-title":"Diagnostic criteria for Parkinson disease","volume":"56","author":"Gelb","year":"1999","journal-title":"Arch Neurol"},{"key":"10.2353\/ajpath.2007.070182_bib38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3940(98)00504-7","article-title":"Filamentous \u03b1-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies","volume":"251","author":"Spillantini","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.2353\/ajpath.2007.070182_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0022-510X(98)00304-9","article-title":"Consensus statement on the diagnosis of multiple system atrophy","volume":"163","author":"Gilman","year":"1999","journal-title":"J Neurol Sci"},{"key":"10.2353\/ajpath.2007.070182_bib40","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0197-4580(97)00057-2","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease","volume":"18","author":"The National Institute on Aging, Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.2353\/ajpath.2007.070182_bib41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1750-3639.1997.tb00893.x","article-title":"The neuropathology of CAG repeat diseases: review and update of genetic and molecular features","volume":"7","author":"Robitaille","year":"1997","journal-title":"Brain Pathol"},{"key":"10.2353\/ajpath.2007.070182_bib42","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/jnnp.60.1.78","article-title":"Neuropathological diagnosis and CAG repeat expansion in Huntington's disease","volume":"60","author":"Xuereb","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.2353\/ajpath.2007.070182_bib43","first-page":"132","article-title":"Overview of dementia lacking distinctive histology: pathological designation of a progressive dementia","volume":"4","author":"Knopman","year":"1993","journal-title":"Dementia"},{"key":"10.2353\/ajpath.2007.070182_bib44","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1212\/01.WNL.0000129543.46734.C0","article-title":"Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia","volume":"63","author":"Hatanpaa","year":"2004","journal-title":"Neurology"},{"key":"10.2353\/ajpath.2007.070182_bib45","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00401-006-0123-3","article-title":"Dementia lacking distinctive histology (DLDH) revisited","volume":"112","author":"Mackenzie","year":"2006","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.2353\/ajpath.2007.070182_bib46","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1177\/40.11.1431060","article-title":"Complete penetration of antibodies into vibratome sections after glutaraldehyde fixation and ethanol treatment: light and electron microscopy for neuropeptides","volume":"40","author":"Llewellyn-Smith","year":"1992","journal-title":"J Histochem Cytochem"},{"key":"10.2353\/ajpath.2007.070182_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0896-6273(03)00606-8","article-title":"The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg","volume":"40","author":"Ciechanover","year":"2003","journal-title":"Neuron"},{"key":"10.2353\/ajpath.2007.070182_bib48","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jmb.2005.02.038","article-title":"Human, Drosophila, and C. elegans TDP43: nucleic acid binding properties and splicing regulatory function","volume":"348","author":"Ayala","year":"2005","journal-title":"J Mol Biol"},{"key":"10.2353\/ajpath.2007.070182_bib49","doi-asserted-by":"crossref","first-page":"13583","DOI":"10.1073\/pnas.212483099","article-title":"Higher order arrangement of the eukaryotic nuclear bodies","volume":"99","author":"Wang","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2007.070182_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nbd.2004.07.008","article-title":"Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias","volume":"17","author":"Thorpe","year":"2004","journal-title":"Neurobiol Dis"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010619578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010619578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:52:11Z","timestamp":1762080731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010619578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0002944010619578"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2007.070182","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2007.070182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}