{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:37:16Z","timestamp":1791077836164,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.2353\/ajpath.2008.070979","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T21:58:12Z","timestamp":1210283892000},"page":"1704-1716","source":"Crossref","is-referenced-by-count":33,"title":["Deleterious Effects of Plasminogen Activators in Neonatal Cerebral Hypoxia-Ischemia"],"prefix":"10.1016","volume":"172","author":[{"given":"Faisal","family":"Adhami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryn","family":"Schloemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay L.","family":"Degen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yi","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2008.070979_bib1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2008.070979_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"19","author":"Rice","year":"1981","journal-title":"Ann Neurol"},{"key":"10.2353\/ajpath.2008.070979_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0306-4522(90)90002-L","article-title":"Systemic administration of MK-801 protects against N-methyl-D-aspartate- and quisqualate-mediated neurotoxicity in perinatal rats","volume":"36","author":"McDonald","year":"1990","journal-title":"Neuroscience"},{"key":"10.2353\/ajpath.2008.070979_bib4","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1242\/jeb.01064","article-title":"Hypoxia-ischemia in the immature brain","volume":"207","author":"Vannucci","year":"2004","journal-title":"J Exp Biol"},{"key":"10.2353\/ajpath.2008.070979_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pediatrneurol.2005.10.015","article-title":"Translational stroke research in the developing brain","volume":"34","author":"Vexler","year":"2006","journal-title":"Pediatr Neurol"},{"key":"10.2353\/ajpath.2008.070979_bib6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/01.WCB.0000137868.50767.E8","article-title":"The neurotoxicity of tissue plasminogen activator?","volume":"24","author":"Kaur","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.2353\/ajpath.2008.070979_bib7","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.STR.0000177517.01203.eb","article-title":"Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia","volume":"36","author":"Tsuji","year":"2005","journal-title":"Stroke"},{"key":"10.2353\/ajpath.2008.070979_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1172\/JCI116637","article-title":"Extracellular proteolysis in the adult murine brain","volume":"92","author":"Sappino","year":"1993","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2008.070979_bib9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/377340a0","article-title":"Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator","volume":"377","author":"Tsirka","year":"1995","journal-title":"Nature"},{"key":"10.2353\/ajpath.2008.070979_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1523\/JNEUROSCI.17-02-00543.1997","article-title":"An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus","volume":"17","author":"Tsirka","year":"1997","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2008.070979_bib11","doi-asserted-by":"crossref","first-page":"13019","DOI":"10.1073\/pnas.2235594100","article-title":"The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia","volume":"100","author":"Junge","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2008.070979_bib12","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1523\/JNEUROSCI.22-09-03352.2002","article-title":"Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II","volume":"22","author":"Siao","year":"2002","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2008.070979_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/83358","article-title":"The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling","volume":"7","author":"Nicole","year":"2001","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2008.070979_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00004647-199605000-00002","article-title":"Proteolytic cascade enzymes increase in focal cerebral ischemia in rat","volume":"16","author":"Rosenberg","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.2353\/ajpath.2008.070979_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0006-8993(99)01645-5","article-title":"Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice","volume":"837","author":"Ahn","year":"1999","journal-title":"Brain Res"},{"key":"10.2353\/ajpath.2008.070979_bib16","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1161\/01.STR.32.6.1341","article-title":"Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion","volume":"32","author":"Hosomi","year":"2001","journal-title":"Stroke"},{"key":"10.2353\/ajpath.2008.070979_bib17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm0298-228","article-title":"Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice","volume":"4","author":"Wang","year":"1998","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2008.070979_bib18","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/01.CIR.99.18.2440","article-title":"Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice","volume":"99","author":"Nagai","year":"1999","journal-title":"Circulation"},{"key":"10.2353\/ajpath.2008.070979_bib19","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1161\/01.ATV.19.11.2801","article-title":"Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background","volume":"19","author":"Tabrizi","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.2353\/ajpath.2008.070979_bib20","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/00004647-200206000-00002","article-title":"Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice","volume":"22","author":"Nagai","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.2353\/ajpath.2008.070979_bib21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1203\/00006450-199005000-00007","article-title":"Cerebral blood flow and edema in perinatal hypoxic-ischemic brain damage","volume":"27","author":"Mujsce","year":"1990","journal-title":"Pediatr Res"},{"key":"10.2353\/ajpath.2008.070979_bib22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2353\/ajpath.2006.051066","article-title":"Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy","volume":"169","author":"Adhami","year":"2006","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2008.070979_bib23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.nbd.2005.07.015","article-title":"TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF","volume":"21","author":"Yin","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.2353\/ajpath.2008.070979_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/368419a0","article-title":"Physiological consequences of loss of plasminogen activator gene function in mice","volume":"368","author":"Carmeliet","year":"1994","journal-title":"Nature"},{"key":"10.2353\/ajpath.2008.070979_bib25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia","volume":"27","author":"Svedin","year":"2007","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2008.070979_bib26","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/01.WCB.0000134476.93809.75","article-title":"2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo","volume":"24","author":"Liot","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.2353\/ajpath.2008.070979_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(87)80039-X","article-title":"Amiloride selectively inhibits the urokinase-type plasminogen activator","volume":"214","author":"Vassalli","year":"1987","journal-title":"FEBS Lett"},{"key":"10.2353\/ajpath.2008.070979_bib28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1203\/01.pdr.0000214975.85311.9c","article-title":"Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants","volume":"59","author":"El-Khoury","year":"2006","journal-title":"Pediatr Res"},{"key":"10.2353\/ajpath.2008.070979_bib29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.STR.0000115164.80010.8A","article-title":"tPA and proteolysis in the neurovascular unit","volume":"35","author":"Lo","year":"2004","journal-title":"Stroke"},{"key":"10.2353\/ajpath.2008.070979_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1160\/TH04-12-0838","article-title":"Tissue plasminogen activator in central nervous system physiology and pathology","volume":"93","author":"Melchor","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.2353\/ajpath.2008.070979_bib31","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1523\/JNEUROSCI.23-26-08867.2003","article-title":"The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration","volume":"23","author":"Melchor","year":"2003","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2008.070979_bib32","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/nm1122","article-title":"Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C","volume":"10","author":"Liu","year":"2004","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2008.070979_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00019052-200204000-00005","article-title":"Perinatal brain injury in the preterm and term newborn","volume":"15","author":"du Plessis","year":"2002","journal-title":"Curr Opin Neurol"},{"key":"10.2353\/ajpath.2008.070979_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/00004647-200106000-00001","article-title":"Tissue-type plasminogen activator is involved in the process of neuronal death induced by oxygen-glucose deprivation in culture","volume":"21","author":"Nagai","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.2353\/ajpath.2008.070979_bib35","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuroscience.2007.01.029","article-title":"Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugs","volume":"146","author":"Leroux","year":"2007","journal-title":"Neuroscience"},{"key":"10.2353\/ajpath.2008.070979_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1203\/00006450-200201000-00007","article-title":"Hypoxic-ischemic oligodendroglial injury in neonatal rat brain","volume":"51","author":"Liu","year":"2002","journal-title":"Pediatr Res"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010619281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010619281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T02:00:00Z","timestamp":1557540000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010619281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0002944010619281"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2008.070979","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}