{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:22:07Z","timestamp":1792146127045,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.2353\/ajpath.2008.071102","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T21:10:19Z","timestamp":1207861819000},"page":"1403-1410","source":"Crossref","is-referenced-by-count":26,"title":["Molecular and Cytogenetic Characterization of Plexiform Leiomyomata Provide Further Evidence for Genetic Heterogeneity Underlying Uterine Fibroids"],"prefix":"10.1016","volume":"172","author":[{"given":"Jennelle C.","family":"Hodge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Quade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Dal Cin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2008.071102_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","article-title":"The frequency of uterine leiomyomas","volume":"94","author":"Cramer","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-2007-1018888","article-title":"Biology of uterine myomas and myometrium in vitro","volume":"10","author":"Rein","year":"1992","journal-title":"Semin Reprod Endocrinol"},{"key":"10.2353\/ajpath.2008.071102_bib3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0029-7844(99)00605-5","article-title":"Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study","volume":"95","author":"Coronado","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.2353\/ajpath.2008.071102_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/01.AOG.0000234651.41000.58","article-title":"Annual costs associated with diagnosis of uterine leiomyomata","volume":"108","author":"Hartmann","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.2353\/ajpath.2008.071102_bib5","first-page":"1","article-title":"Hysterectomy surveillance\u2014United States, 1980\u20131993","volume":"46","author":"Lepine","year":"1997","journal-title":"MMWR CDC Surveill Summ"},{"key":"10.2353\/ajpath.2008.071102_bib6","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.ajog.2006.02.020","article-title":"Health care resource use for uterine fibroid tumors in the United States","volume":"195","author":"Flynn","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.2353\/ajpath.2008.071102_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gcc.2870020103","article-title":"Uterine leiomyoma cytogenetics","volume":"2","author":"Nibert","year":"1990","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib8","first-page":"923","article-title":"Cytogenetic abnormalities in uterine leiomyomata","volume":"77","author":"Rein","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.2353\/ajpath.2008.071102_bib9","first-page":"209","article-title":"Uterine leiomyomas: cytogenetic and histologic profile","volume":"80","author":"Meloni","year":"1992","journal-title":"Obstet Gynecol"},{"key":"10.2353\/ajpath.2008.071102_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/gcc.10240","article-title":"HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies","volume":"38","author":"Gross","year":"2003","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-2264(199609)17:1<1::AID-GCC1>3.0.CO;2-0","article-title":"Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas","volume":"17","author":"Schoenberg Fejzo","year":"1996","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib12","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng0895-436","article-title":"Recurrent rearrangements in the high mobility group protein gene. HMGI-C, in benign mesenchymal tumours","volume":"10","author":"Schoenmakers","year":"1995","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2008.071102_bib13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0168-9525(94)90232-1","article-title":"HMG domain proteins: architectural elements in the assembly of nucleoprotein structures","volume":"10","author":"Grosschedl","year":"1994","journal-title":"Trends Genet"},{"key":"10.2353\/ajpath.2008.071102_bib14","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.8178167","article-title":"Architectural transcription factors","volume":"264","author":"Wolffe","year":"1994","journal-title":"Science"},{"key":"10.2353\/ajpath.2008.071102_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-1119(01)00689-8","article-title":"Molecular biology of HMGA proteins: hubs of nuclear function","volume":"277","author":"Reeves","year":"2001","journal-title":"Gene"},{"key":"10.2353\/ajpath.2008.071102_bib16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1086\/427565","article-title":"Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas","volume":"76","author":"Ligon","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.2353\/ajpath.2008.071102_bib17","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ng2121","article-title":"A common variant of HMGA2 is associated with adult and childhood height in the general population","volume":"39","author":"Weedon","year":"2007","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2008.071102_bib18","series-title":"Diagnostic Gynecologic and Obstetric Pathology","article-title":"Uterine mesenchymal tumors, chapter 20","author":"Nucci","year":"2005"},{"key":"10.2353\/ajpath.2008.071102_bib19","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/1097-0142(197604)37:4<1853::AID-CNCR2820370433>3.0.CO;2-E","article-title":"Mesenchymal tumors of the uterus. VI. Epithelioid smooth muscle tumors including leiomyoblastoma and clear-cell leiomyoma: a clinical and pathologic analysis of 26 cases","volume":"37","author":"Kurman","year":"1976","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1097-0142(197202)29:2<305::AID-CNCR2820290206>3.0.CO;2-V","article-title":"Gastric and extragastric leiomyoblastomas: clinicopathologic study of 44 cases","volume":"29","author":"Lavin","year":"1972","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib21","first-page":"1189","article-title":"Uterine leiomyoblastoma (epithelioid leiomyoma) neoplasm of low-grade malignancy. A histopathologic study","volume":"116","author":"Kyriazis","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"10.2353\/ajpath.2008.071102_bib22","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/1097-0142(19881115)62:10<2239::AID-CNCR2820621028>3.0.CO;2-Y","article-title":"Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors","volume":"62","author":"Evans","year":"1988","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00000478-198004010-00006","article-title":"Histogenesis of morphologic variations in tumors of the uterine wall","volume":"4","author":"Mazur","year":"1980","journal-title":"Am J Surg Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/003130299105197","article-title":"Plexiform leiomyoma of the uterus in a patient with breast carcinoma: case report and review of the literature","volume":"31","author":"Nagel","year":"1999","journal-title":"Pathology"},{"key":"10.2353\/ajpath.2008.071102_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00004347-198402000-00002","article-title":"Plexiform tumorlet: a clinical and pathologic study of 15 cases with ultrastructural observations","volume":"3","author":"Kaminski","year":"1984","journal-title":"Int J Gynecol Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib26","first-page":"1255","article-title":"Multiple plexiform tumorlets of the uterus","volume":"117","author":"Seidman","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"10.2353\/ajpath.2008.071102_bib27","first-page":"263","article-title":"Smooth muscle origin of uterine plexiform tumors","volume":"97","author":"Goodhue","year":"1974","journal-title":"Arch Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib28","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/1097-0142(197911)44:5<1707::AID-CNCR2820440526>3.0.CO;2-5","article-title":"Plexiform tumors of the uterus: ultrastructural study","volume":"44","author":"Nunez-Alonso","year":"1979","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib29","first-page":"477","article-title":"The myofibroblastic nature of the uterine plexiform tumor","volume":"102","author":"Fisher","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"10.2353\/ajpath.2008.071102_bib30","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/35057192","article-title":"Integration of cytogenetic landmarks into the draft sequence of the human genome","volume":"409","author":"Cheung","year":"2001","journal-title":"Nature"},{"key":"10.2353\/ajpath.2008.071102_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/nar\/gkg129","article-title":"The UCSC Genome Browser Database","volume":"31","author":"Karolchik","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2008.071102_bib32","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1158\/0008-5472.CAN-04-0050","article-title":"Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF","volume":"64","author":"Moore","year":"2004","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2008.071102_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1593\/neo.05664","article-title":"Defining aggressive prostate cancer using a 12-gene model","volume":"8","author":"Bismar","year":"2006","journal-title":"Neoplasia"},{"key":"10.2353\/ajpath.2008.071102_bib34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gcc.20291","article-title":"Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features","volume":"45","author":"Christacos","year":"2006","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/gcc.20018","article-title":"Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling","volume":"40","author":"Quade","year":"2004","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib36","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1128\/MCB.19.8.5237","article-title":"Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins","volume":"19","author":"Bustin","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2008.071102_bib37","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0002-9440(10)65469-7","article-title":"Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas","volume":"155","author":"Klotzb\u00fccher","year":"1999","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/modpathol.3880529","article-title":"Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case","volume":"15","author":"Quade","year":"2002","journal-title":"Mod Pathol"},{"key":"10.2353\/ajpath.2008.071102_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/gcc.10159","article-title":"Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)","volume":"36","author":"Dal Cin","year":"2003","journal-title":"Genes Chromosom Cancer"},{"key":"10.2353\/ajpath.2008.071102_bib40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/gyno.1996.0319","article-title":"Malignant plexiform tumor of the uterus: an unusual variant of epithelioid leiomyosarcoma","volume":"63","author":"Kuroda","year":"1996","journal-title":"Gynecol Oncol"},{"key":"10.2353\/ajpath.2008.071102_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0165-4608(94)00167-A","article-title":"Cytogenetic findings in uterine epithelioid leiomyomas","volume":"80","author":"Karaiskos","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.2353\/ajpath.2008.071102_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-4608(94)90151-1","article-title":"Translocations in 7q22 define a critical region in uterine leiomyomata","volume":"77","author":"Sargent","year":"1994","journal-title":"Cancer Genet Cytogenet"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010618986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010618986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T05:55:57Z","timestamp":1546149357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010618986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0002944010618986"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2008.071102","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}