{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:45:09Z","timestamp":1762015509588},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.2353\/ajpath.2008.080487","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T01:06:37Z","timestamp":1225415197000},"page":"1647-1656","source":"Crossref","is-referenced-by-count":19,"title":["Fc Gamma Receptor Signaling in Mast Cells Links Microbial Stimulation to Mucosal Immune Inflammation in the Intestine"],"prefix":"10.1016","volume":"173","author":[{"given":"Xiao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai-Sui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Yuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Qing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Guo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Chang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2008.080487_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.clnu.2005.02.009","article-title":"Aetiology of inflammatory bowel disease (IBD): role of intestinal microbiota and gut-associated lymphoid tissue immune response","volume":"24","author":"Thompson-Chagoy\u00e1n","year":"2005","journal-title":"Clin Nutr"},{"key":"10.2353\/ajpath.2008.080487_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ncpgasthep1004","article-title":"Infections and IBD","volume":"5","author":"Irving","year":"2008","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.2353\/ajpath.2008.080487_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1462-5822.2001.00090.x","article-title":"The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota","volume":"3","author":"McCracken","year":"2001","journal-title":"Cell Microbiol"},{"issue":"Suppl 4","key":"10.2353\/ajpath.2008.080487_bib4","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1038\/sj.ejcn.1601662","article-title":"Role of microecology in chronic inflammatory bowel diseases","volume":"56","author":"Guarner","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"10.2353\/ajpath.2008.080487_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1572-0241.2002.05613.x","article-title":"Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease","volume":"97","author":"Neut","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.2353\/ajpath.2008.080487_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s11894-006-0039-z","article-title":"The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease","volume":"8","author":"Ewaschuk","year":"2006","journal-title":"Curr Gastroenterol Rep"},{"issue":"Suppl 3","key":"10.2353\/ajpath.2008.080487_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2036.2006.03053.x","article-title":"Review article: the role of bacteria in onset and perpetuation of inflammatory bowel disease","volume":"24","author":"Seksik","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.2353\/ajpath.2008.080487_bib8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1074-7613(00)00045-5","article-title":"CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal","volume":"13","author":"Schulz","year":"2000","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2008.080487_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.0105-2896.2005.00291.x","article-title":"Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota","volume":"206","author":"Elson","year":"2005","journal-title":"Immunol Rev"},{"key":"10.2353\/ajpath.2008.080487_bib10","first-page":"393","article-title":"New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases","volume":"69","author":"Latinne","year":"2006","journal-title":"Acta Gastroenterol Belg"},{"key":"10.2353\/ajpath.2008.080487_bib11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1172\/JCI30587","article-title":"The fundamental basis of inflammatory bowel disease","volume":"117","author":"Strober","year":"2007","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2008.080487_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.imlet.2005.05.004","article-title":"Salmonella flagellin, a microbial target of the innate and adaptive immune system","volume":"101","author":"Salazar-Gonzalez","year":"2005","journal-title":"Immunol Lett"},{"key":"10.2353\/ajpath.2008.080487_bib13","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI200420295","article-title":"Bacterial flagellin is a dominant antigen in Crohn disease","volume":"113","author":"Lodes","year":"2004","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2008.080487_bib14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1572-0241.2007.01577.x","article-title":"IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin","volume":"103","author":"Adams","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.2353\/ajpath.2008.080487_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3748\/wjg.v10.i3.309","article-title":"Key role of mast cells and their major secretory products in inflammatory bowel disease","volume":"10","author":"He","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.2353\/ajpath.2008.080487_bib16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00535-003-1117-8","article-title":"Clinical features and pattern of indeterminate colitis: Crohn's disease with ulcerative colitis-like clinical presentation","volume":"38","author":"Matsui","year":"2003","journal-title":"J Gastroenterol"},{"key":"10.2353\/ajpath.2008.080487_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jcp.55.1.51","article-title":"Discriminant histological features in the diagnosis of chronic idiopathic inflammatory bowel disease: analysis of a large dataset by a novel data visualisation technique","volume":"55","author":"Cross","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.2353\/ajpath.2008.080487_bib18","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1053\/j.gastro.2007.08.006","article-title":"TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy","volume":"133","author":"Yang","year":"2007","journal-title":"Gastroenterology"},{"key":"10.2353\/ajpath.2008.080487_bib19","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2008.080487_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2353\/ajpath.2007.061274","article-title":"Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea","volume":"171","author":"Feng","year":"2007","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2008.080487_bib21","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.molimm.2007.09.013","article-title":"Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin","volume":"45","author":"Keestra","year":"2008","journal-title":"Mol Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jaci.2004.03.049","article-title":"Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3","volume":"114","author":"Kulka","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib23","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.4049\/jimmunol.174.10.5987","article-title":"TGF-beta 1 inhibits mast cell Fc epsilon RI expression","volume":"174","author":"Gomez","year":"2005","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4049\/jimmunol.177.1.694","article-title":"Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells","volume":"177","author":"Zhao","year":"2006","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib25","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.4049\/jimmunol.179.5.2758","article-title":"CD4+ T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism","volume":"179","author":"Nieuwenhuizen","year":"2007","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/0968051907079101","article-title":"Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia","volume":"13","author":"van der Meer","year":"2007","journal-title":"J Endotoxin Res"},{"key":"10.2353\/ajpath.2008.080487_bib27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s11894-004-0070-x","article-title":"Relevance of serologic studies in inflammatory bowel disease","volume":"6","author":"Vernier","year":"2004","journal-title":"Curr Gastroenterol Rep"},{"key":"10.2353\/ajpath.2008.080487_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1572-0241.2006.00456.x","article-title":"Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression","volume":"101","author":"Dubinsky","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.2353\/ajpath.2008.080487_bib29","doi-asserted-by":"crossref","first-page":"e1413","DOI":"10.1371\/journal.pone.0001413","article-title":"Human IgG\/FcgammaR interactions are modulated by streptococcal IgG glycan hydrolysis","volume":"3","author":"Allhorn","year":"2008","journal-title":"PLoS ONE"},{"key":"10.2353\/ajpath.2008.080487_bib30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4049\/jimmunol.180.1.618","article-title":"Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes","volume":"180","author":"Jakus","year":"2008","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2008.080487_bib31","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/nm1665","article-title":"CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation","volume":"13","author":"Pinheiro da Silva","year":"2007","journal-title":"Nat Med"},{"key":"10.2353\/ajpath.2008.080487_bib32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking","volume":"116","author":"Strait","year":"2006","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2008.080487_bib33","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1128\/IAI.01491-07","article-title":"Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease","volume":"76","author":"Vijay-Kumar","year":"2008","journal-title":"Infect Immun"},{"key":"10.2353\/ajpath.2008.080487_bib34","doi-asserted-by":"crossref","first-page":"13610","DOI":"10.1073\/pnas.0502174102","article-title":"Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation","volume":"102","author":"Rhee","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2008.080487_bib35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2353\/ajpath.2006.050575","article-title":"Chronic psychological stress in rats induces intestinal sensitization to luminal antigens","volume":"168","author":"Yang","year":"2006","journal-title":"Am J Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010615507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010615507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:57:15Z","timestamp":1557881835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010615507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0002944010615507"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2008.080487","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}