{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:13:52Z","timestamp":1770819232714,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.2353\/ajpath.2009.080392","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T02:36:44Z","timestamp":1232073404000},"page":"475-485","source":"Crossref","is-referenced-by-count":33,"title":["Pemphigus Vulgaris IgG Cause Loss of Desmoglein-Mediated Adhesion and Keratinocyte Dissociation Independent of Epidermal Growth Factor Receptor"],"prefix":"10.1016","volume":"174","author":[{"given":"Wolfgang-Moritz","family":"Heupel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Engerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Waschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2009.080392_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00418-008-0420-0","article-title":"The desmosome and pemphigus","volume":"130","author":"Waschke","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib2","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMra061111","article-title":"Pemphigus bullous impetigo, and the staphylococcal scalded-skin syndrome","volume":"355","author":"Stanley","year":"2006","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2009.080392_bib3","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198205203062001","article-title":"Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease","volume":"306","author":"Anhalt","year":"1982","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2009.080392_bib4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"10.2353\/ajpath.2009.080392_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1172\/JCI111426","article-title":"Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies","volume":"74","author":"Stanley","year":"1984","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2009.080392_bib6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI115968","article-title":"Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic","volume":"90","author":"Amagai","year":"1992","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2009.080392_bib7","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI10305","article-title":"Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions","volume":"106","author":"Nguyen","year":"2000","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2009.080392_bib8","doi-asserted-by":"crossref","first-page":"29466","DOI":"10.1074\/jbc.M003174200","article-title":"Pemphigus Vulgaris Antibody Identifies Pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine","volume":"275","author":"Nguyen","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib9","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0002-9440(10)64651-2","article-title":"Novel human {alpha}9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity","volume":"157","author":"Nguyen","year":"2000","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2009.080392_bib10","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/sj.jid.5701260","article-title":"E-cadherin is an additional immunological target for pemphigus autoantibodies","volume":"128","author":"Evangelista","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080392_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1523-1747.2003.12014.x","article-title":"Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8","volume":"120","author":"Puviani","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080392_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1600-0625.2006.00499_1.x","article-title":"Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just \u2018witnesses of disease\u2019?","volume":"15","author":"Amagai","year":"2006","journal-title":"Exp Dermatol"},{"key":"10.2353\/ajpath.2009.080392_bib13","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1172\/JCI23475","article-title":"Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction","volume":"115","author":"Waschke","year":"2005","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2009.080392_bib14","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.181.3.1825","article-title":"Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction","volume":"181","author":"Heupel","year":"2008","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2009.080392_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.jid.5701248","article-title":"Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation?","volume":"128","author":"Muller","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080392_bib16","doi-asserted-by":"crossref","first-page":"23778","DOI":"10.1074\/jbc.M501365200","article-title":"Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization","volume":"280","author":"Berkowitz","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib17","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.1073\/pnas.0602973103","article-title":"p38MAPK inhibition prevents disease in pemphigus vulgaris mice","volume":"103","author":"Berkowitz","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080392_bib18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1083\/jcb.200605125","article-title":"Inhibition of Rho A activity causes pemphigus skin blistering","volume":"175","author":"Waschke","year":"2006","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.153.4.823","article-title":"A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris","volume":"153","author":"Caldelari","year":"2001","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib20","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1038\/sj.emboj.7601224","article-title":"Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin","volume":"25","author":"Williamson","year":"2006","journal-title":"EMBO J"},{"key":"10.2353\/ajpath.2009.080392_bib21","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1074\/jbc.M702186200","article-title":"Evidence of key role of CDK-2 overexpression in pemphigus vulgaris","volume":"283","author":"Lanza","year":"2008","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"10.2353\/ajpath.2009.080392_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib24","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1074\/jbc.M109136200","article-title":"c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis","volume":"277","author":"Simeonova","year":"2002","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib25","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1083\/jcb.146.4.697","article-title":"Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways","volume":"146","author":"Carpenter","year":"2002","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib26","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.127.5.1375","article-title":"Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor","volume":"127","author":"Hoschuetzky","year":"1994","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib27","doi-asserted-by":"crossref","first-page":"24871","DOI":"10.1074\/jbc.M102731200","article-title":"Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation","volume":"276","author":"Gaudry","year":"2001","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib28","doi-asserted-by":"crossref","first-page":"40355","DOI":"10.1074\/jbc.M506692200","article-title":"Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor","volume":"280","author":"Yin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/08916930600971836","article-title":"Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis\u2013possible involvement of the EGF receptor","volume":"39","author":"Frusic-Zlotkin","year":"2006","journal-title":"Autoimmunity"},{"key":"10.2353\/ajpath.2009.080392_bib30","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.1074\/jbc.M611365200","article-title":"Desmoglein VS. non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens","volume":"282","author":"Chernyavsky","year":"2007","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib31","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib32","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080392_bib33","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1074\/jbc.274.12.8335","article-title":"c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function","volume":"274","author":"Biscardi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib34","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2353\/ajpath.2007.070028","article-title":"Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3","volume":"171","author":"Spindler","year":"2007","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2009.080392_bib35","doi-asserted-by":"crossref","first-page":"37191","DOI":"10.1074\/jbc.M405123200","article-title":"Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells","volume":"279","author":"Lorch","year":"2004","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib36","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1074\/jbc.M608826200","article-title":"Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors","volume":"282","author":"Santiago-Josefat","year":"2007","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib37","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1128\/MCB.02380-05","article-title":"Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis","volume":"26","author":"Bech-Serra","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2009.080392_bib38","doi-asserted-by":"crossref","first-page":"41227","DOI":"10.1074\/jbc.M006578200","article-title":"Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation","volume":"275","author":"Pece","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080392_bib39","doi-asserted-by":"crossref","first-page":"19347","DOI":"10.1074\/jbc.274.27.19347","article-title":"Activation of the protein kinase Akt\/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex","volume":"274","author":"Pece","year":"1999","journal-title":"J Biol Chem"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010613065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010613065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T13:55:56Z","timestamp":1545486956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010613065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0002944010613065"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2009.080392","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}