{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:56Z","timestamp":1787025176000,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014080","name":"Graduate School, University of Oregon","doi-asserted-by":"publisher","award":["GK 1033"],"award-info":[{"award-number":["GK 1033"]}],"id":[{"id":"10.13039\/100014080","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.2353\/ajpath.2009.080832","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T21:55:51Z","timestamp":1249595751000},"page":"1019-1029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts"],"prefix":"10.1016","volume":"175","author":[{"given":"Marc","family":"Majora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Wittkampf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Grether-Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Wilichowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Bernerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2009.080832_bib1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.0022-3042.2002.00744.x","article-title":"Generation of reactive oxygen species by the mitochondrial electron transport chain","volume":"80","author":"Liu","year":"2002","journal-title":"J Neurochem"},{"key":"10.2353\/ajpath.2009.080832_bib2","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive","volume":"85","author":"Richter","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib3","doi-asserted-by":"crossref","first-page":"7915","DOI":"10.1073\/pnas.90.17.7915","article-title":"Oxidants, antioxidants, and the degenerative diseases of aging","volume":"90","author":"Ames","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib4","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.71.7.2777","article-title":"The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria","volume":"71","author":"Clayton","year":"1974","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1023\/B:NERE.0000014829.42364.dd","article-title":"Mitochondrial disease: mutations and mechanisms","volume":"29","author":"McKenzie","year":"2004","journal-title":"Neurochem Res"},{"key":"10.2353\/ajpath.2009.080832_bib6","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1056\/NEJMra022567","article-title":"Mitochondrial respiratory-chain diseases","volume":"348","author":"DiMauro","year":"2003","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2009.080832_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/507132","article-title":"Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers","volume":"79","author":"Bua","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.2353\/ajpath.2009.080832_bib8","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1093\/nar\/18.23.6927","article-title":"Detection of a specific mitochondrial DNA deletion in tissues of older humans","volume":"18","author":"Cortopassi","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2009.080832_bib9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2009.080832_bib10","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.274.22.15345","article-title":"Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion","volume":"274","author":"Berneburg","year":"1999","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080832_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.2353\/ajpath.2009.080832_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"key":"10.2353\/ajpath.2009.080832_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.1998.00099.x","article-title":"Mitochondrial DNA deletions in human skin reflect photo-rather than chronologic aging","volume":"110","author":"Birch-Machin","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1523-1747.1998.00337.x","article-title":"Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging","volume":"111","author":"Berneburg","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib15","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.0022-202X.2004.22502.x","article-title":"Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin","volume":"122","author":"Berneburg","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib16","series-title":"Skin Aging","first-page":"33","article-title":"Photoaging of skin","author":"Krutmann","year":"2006"},{"key":"10.2353\/ajpath.2009.080832_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1751-1097.1997.tb08654.x","article-title":"Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system","volume":"66","author":"Berneburg","year":"1997","journal-title":"Photochem Photobiol"},{"key":"10.2353\/ajpath.2009.080832_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.0022-202X.2005.23806.x","article-title":"Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences","volume":"125","author":"Berneburg","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1073\/pnas.76.3.1274","article-title":"Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro","volume":"76","author":"Bell","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib20","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.jid.5700230","article-title":"Interactions between fibroblasts and keratinocytes in morphogenesis of dermal epidermal junction in a model of reconstructed skin","volume":"126","author":"Marionnet","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1751-1097.2005.tb01517.x","article-title":"Reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro: a model to study hypersensitivity to UV light","volume":"81","author":"Bernerd","year":"2005","journal-title":"Photochem Photobiol"},{"key":"10.2353\/ajpath.2009.080832_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/1523-1747.ep12464379","article-title":"Epithelial differentiation of human skin equivalents after grafting onto nude mice","volume":"91","author":"Bosca","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2006.07.035","article-title":"Gene silencing in a human organotypic skin model","volume":"348","author":"Mildner","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 27","key":"10.2353\/ajpath.2009.080832_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2133.1984.tb15608.x","article-title":"Reconstruction of \u2018simplified\u2019 skin: control of fabrication","volume":"111","author":"Asselineau","year":"1984","journal-title":"Br J Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib25","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1073\/pnas.141221998","article-title":"Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro","volume":"98","author":"Bernerd","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib26","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1046\/j.0022-202x.2001.01513.x","article-title":"In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation","volume":"117","author":"Koch","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib27","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/sj.jid.5701151","article-title":"Sunbed use induces the photoaging-associated mitochondrial common deletion","volume":"128","author":"Reimann","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2133.1995.tb02620.x","article-title":"Influence of the extracellular matrix on fibroblast responsiveness to phenytoin using in vitro wound healing models","volume":"133","author":"Genever","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2133.1994.tb08518.x","article-title":"Immunohistochemical localization of lysyl oxidase in normal human skin","volume":"131","author":"Kobayashi","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10735-004-2340-1","article-title":"Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues","volume":"35","author":"Hayashi","year":"2004","journal-title":"J Mol Histol"},{"key":"10.2353\/ajpath.2009.080832_bib31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0006-291X(77)90972-X","article-title":"Isolation and characterization of a fluorescent material in bovine achilles tendon collagen","volume":"76","author":"Fujimoto","year":"1977","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2009.080832_bib32","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0006-291X(82)80132-0","article-title":"A novel fluor in insoluble collagen: a crosslinking moiety in collagen molecule","volume":"107","author":"Ogawa","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2009.080832_bib33","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/1523-1747.ep12481920","article-title":"Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction","volume":"97","author":"Woodley","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib34","doi-asserted-by":"crossref","first-page":"12817","DOI":"10.1073\/pnas.94.24.12817","article-title":"Localization and activity of lysyl oxidase within nuclei of fibrogenic cells","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080832_bib35","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.1158\/0008-5472.CAN-05-1274","article-title":"Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism","volume":"65","author":"Payne","year":"2005","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2009.080832_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jcb.20792","article-title":"Lysyl oxidase regulates actin filament formation through the p130(Cas)\/Crk\/DOCK180 signaling complex","volume":"98","author":"Payne","year":"2006","journal-title":"J Cell Biochem"},{"key":"10.2353\/ajpath.2009.080832_bib37","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","article-title":"Lysyl oxidase is essential for hypoxia-induced metastasis","volume":"440","author":"Erler","year":"2006","journal-title":"Nature"},{"key":"10.2353\/ajpath.2009.080832_bib38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2990.2007.00858.x","article-title":"Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)\/paxillin activation and migration in invasive astrocytes","volume":"33","author":"Laczko","year":"2007","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.2353\/ajpath.2009.080832_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0781.2007.00298.x","article-title":"Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol, and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation","volume":"23","author":"Cho","year":"2007","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.2353\/ajpath.2009.080832_bib40","first-page":"F278","article-title":"ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling","volume":"276","author":"Zent","year":"1999","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2009.080832_bib41","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1016\/j.febslet.2005.11.034","article-title":"Free radicals-mediated damage in transmitochondrial cells harboring the T14487C mutation in the ND6 gene of mtDNA","volume":"579","author":"Gonzalo","year":"2005","journal-title":"FEBS Lett"},{"key":"10.2353\/ajpath.2009.080832_bib42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1196\/annals.1338.024","article-title":"Enhanced generation of mitochondrial reactive oxygen species in cybrids containing 4977-bp mitochondrial DNA deletion","volume":"1042","author":"Jou","year":"2005","journal-title":"Ann NY Acad Sci"},{"key":"10.2353\/ajpath.2009.080832_bib43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbadis.2005.10.008","article-title":"Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress","volume":"1762","author":"Peng","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.2353\/ajpath.2009.080832_bib44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.freeradbiomed.2006.09.014","article-title":"Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript","volume":"42","author":"Alemi","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.2353\/ajpath.2009.080832_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/jbm.a.10021","article-title":"Enhancing mechanical properties of tissue-engineered constructs via lysyl oxidase crosslinking activity","volume":"66","author":"Elbjeirami","year":"2003","journal-title":"J Biomed Mater Res A"},{"key":"10.2353\/ajpath.2009.080832_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF02505035","article-title":"Detection of lysyl oxidase gene expression in rat skin during wound healing","volume":"288","author":"Fushida-Takemura","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.2353\/ajpath.2009.080832_bib47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.2353\/ajpath.2009.080832_bib48","doi-asserted-by":"crossref","first-page":"d982","DOI":"10.2741\/1114","article-title":"Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility","volume":"8","author":"Hanks","year":"2003","journal-title":"Front Biosci"},{"key":"10.2353\/ajpath.2009.080832_bib49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-2230.2002.01096.x","article-title":"Effects of antioxidants on pyridinoline cross-link formation in culture supernatants of fibroblasts from normal skin and hypertrophic scars","volume":"27","author":"Wan","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib50","first-page":"949","article-title":"Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways","volume":"6","author":"Weyant","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2009.080832_bib51","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1126\/science.1697103","article-title":"Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-ras","volume":"249","author":"Contente","year":"1990","journal-title":"Science"},{"key":"10.2353\/ajpath.2009.080832_bib52","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0945-053X(05)80015-0","article-title":"Induction of human monocyte motility by lysyl oxidase","volume":"14","author":"Lazarus","year":"1995","journal-title":"Matrix Biol"},{"key":"10.2353\/ajpath.2009.080832_bib53","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/1097-4644(20000915)78:4<550::AID-JCB4>3.0.CO;2-8","article-title":"Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells","volume":"78","author":"Li","year":"2000","journal-title":"J Cell Biochem"},{"key":"10.2353\/ajpath.2009.080832_bib54","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/jid.2008.57","article-title":"Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin","volume":"128","author":"Schroeder","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080832_bib55","unstructured":"Krutmann J, Schroeder P: Role of mitochondria in photoageing of human skin: the defective powerhouse model. J Invest Dermatol Symp Proc 2008, (in press)"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010606128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010606128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:02:26Z","timestamp":1757599346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010606128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0002944010606128"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2009.080832","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2009.080832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}