{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:16:13Z","timestamp":1792444573934,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.2353\/ajpath.2009.080953","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T03:26:16Z","timestamp":1257477976000},"page":"2416-2429","source":"Crossref","is-referenced-by-count":68,"title":["Expression of Activated STAT5 in Neoplastic Mast Cells in Systemic Mastocytosis"],"prefix":"10.1016","volume":"175","author":[{"given":"Christian","family":"Baumgartner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Cerny-Reiterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Sonneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mayerhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline V.","family":"Gleixner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Kerenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Boudot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Gouilleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Wilhelm","family":"Kornfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sillaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Moriggl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Valent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2009.080953_bib1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0046-8177(85)80252-5","article-title":"Bone marrow findings in systemic mastocytosis","volume":"16","author":"Horny","year":"1985","journal-title":"Hum Pathol"},{"key":"10.2353\/ajpath.2009.080953_bib2","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1111\/1523-1747.ep12468882","article-title":"Classification and diagnosis of mastocytosis: current status","volume":"96","author":"Metcalfe","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2009.080953_bib3","first-page":"385","article-title":"Biology, classification and treatment of human mastocytosis","volume":"108","author":"Valent","year":"1996","journal-title":"Wien Klin Wochenschr"},{"key":"10.2353\/ajpath.2009.080953_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.med.55.091902.103822","article-title":"Systemic mastocytosis","volume":"55","author":"Akin","year":"2004","journal-title":"Annu Rev Med"},{"key":"10.2353\/ajpath.2009.080953_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00062752-200401000-00009","article-title":"Clinical, genetic, and therapeutic insights into systemic mast cell disease","volume":"11","author":"Tefferi","year":"2004","journal-title":"Curr Opin Hematol"},{"key":"10.2353\/ajpath.2009.080953_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"key":"10.2353\/ajpath.2009.080953_bib7","first-page":"291","article-title":"Mastocytosis","volume":"vol 1","author":"Valent","year":"2001"},{"key":"10.2353\/ajpath.2009.080953_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0145-2126(02)00168-6","article-title":"Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria","volume":"27","author":"Valent","year":"2003","journal-title":"Leuk Res"},{"key":"10.2353\/ajpath.2009.080953_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0025-6196(12)62636-6","article-title":"Mast cell leukemia: report of a case and review of the literature","volume":"61","author":"Travis","year":"1986","journal-title":"Mayo Clin Proc"},{"key":"10.2353\/ajpath.2009.080953_bib10","doi-asserted-by":"crossref","first-page":"10560","DOI":"10.1073\/pnas.92.23.10560","article-title":"Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder","volume":"92","author":"Nagata","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2009.080953_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng0396-312","article-title":"Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm","volume":"12","author":"Longley","year":"1996","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2009.080953_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2141.2001.02783.x","article-title":"Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis","volume":"113","author":"Fritsche-Polanz","year":"2001","journal-title":"Br J Haematol"},{"key":"10.2353\/ajpath.2009.080953_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000048179","article-title":"Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts","volume":"127","author":"Feger","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib14","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI116761","article-title":"Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product","volume":"92","author":"Furitsu","year":"1993","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2009.080953_bib15","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.4049\/jimmunol.180.8.5466","article-title":"Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens","volume":"180","author":"Mayerhofer","year":"2008","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0889-8588(05)70294-X","article-title":"Kit signal transduction","volume":"14","author":"Taylor","year":"2000","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.2353\/ajpath.2009.080953_bib17","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1073\/pnas.93.25.14665","article-title":"Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1","volume":"93","author":"Piao","year":"1996","journal-title":"Proc Natl Acad Sci (USA)"},{"key":"10.2353\/ajpath.2009.080953_bib18","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood.V98.5.1365","article-title":"Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant","volume":"98","author":"Chian","year":"2001","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib19","first-page":"357","article-title":"Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells","volume":"25","author":"Ryan","year":"1997","journal-title":"Exp Hematol"},{"key":"10.2353\/ajpath.2009.080953_bib20","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0161-5890(02)00061-5","article-title":"Stat5: an essential regulator of mast cell biology","volume":"38","author":"Shelburne","year":"2002","journal-title":"Mol Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib21","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1182\/blood-2002-11-3490","article-title":"Stat5 expression is critical for mast cell development and survival","volume":"102","author":"Shelburne","year":"2003","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000085431","article-title":"Stat5a is essential for the proliferation and survival of murine mast cells","volume":"137","author":"Ikeda","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib23","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1182\/blood-2002-04-1204","article-title":"Signal transducer and activator of transcription proteins in leukemias","volume":"101","author":"Benekli","year":"2003","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib24","first-page":"2140","article-title":"Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells","volume":"9","author":"Spiekermann","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2009.080953_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-2184.2003.00283.x","article-title":"The influence of STAT5 antisense oligonucleotides on the proliferation and apoptosis of selected human leukaemic cell lines","volume":"36","author":"Baskiewicz-Masiuk","year":"2003","journal-title":"Cell Prolif"},{"key":"10.2353\/ajpath.2009.080953_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ccr.2004.12.010","article-title":"Stat5 tetramer formation is associated with leukemogenesis","volume":"7","author":"Moriggl","year":"2005","journal-title":"Cancer Cell"},{"key":"10.2353\/ajpath.2009.080953_bib27","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1182\/blood-2006-01-029918","article-title":"Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias","volume":"109","author":"Harir","year":"2007","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2141.2007.06708.x","article-title":"Detection of phospho-STAT5 in mast cells: a reliable phenotypic marker of systemic mast cell disease that reflects constitutive tyrosine kinase activation","volume":"139","author":"Zuluaga Toro","year":"2007","journal-title":"Br J Haematol"},{"key":"10.2353\/ajpath.2009.080953_bib29","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1182\/blood-2007-09-115477","article-title":"Oncogenic Kit controls neoplastic mast cell growth through a Stat5\/PI 3-kinase signaling cascade","volume":"112","author":"Harir","year":"2008","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib30","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood.V91.8.2731.2731_2731_2736","article-title":"Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications","volume":"91","author":"Escribano","year":"1998","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2362.2008.01942.x","article-title":"Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared with flow cytometry","volume":"38","author":"Baumgartner","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"10.2353\/ajpath.2009.080953_bib32","first-page":"17","article-title":"PKC412 - a protein kinase inhibitor with a broad therapeutic potential","volume":"15","author":"Fabbro","year":"2000","journal-title":"Anticancer Drug Des"},{"key":"10.2353\/ajpath.2009.080953_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","article-title":"Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl","volume":"7","author":"Weisberg","year":"2005","journal-title":"Cancer Cell"},{"key":"10.2353\/ajpath.2009.080953_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0145-2126(88)90050-1","article-title":"Establishment of an immature mast cell line from a patient with mast cell leukemia","volume":"12","author":"Butterfield","year":"1988","journal-title":"Leuk Res"},{"key":"10.2353\/ajpath.2009.080953_bib35","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.4049\/jimmunol.147.12.4224","article-title":"IL-4 regulates c-kit proto-oncogene product expression in human mast and myeloid progenitor cells","volume":"147","author":"Sillaber","year":"1991","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0301-472X(03)00112-7","article-title":"Effects of tyrosine kinase inhibitor ST1571 on human mast cells bearing wild-type or mutated c-kit","volume":"31","author":"Akin","year":"2003","journal-title":"Exp Hematol"},{"key":"10.2353\/ajpath.2009.080953_bib37","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1182\/blood-2005-07-3022","article-title":"PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects","volume":"107","author":"Gleixner","year":"2006","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"10.2353\/ajpath.2009.080953_bib39","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/00000478-199809000-00013","article-title":"Diagnostic value of immunostaining for tryptase in patients with mastocytosis","volume":"22","author":"Horny","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.2353\/ajpath.2009.080953_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/path.1711710205","article-title":"Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections","volume":"171","author":"Cattoretti","year":"1993","journal-title":"J Pathol"},{"key":"10.2353\/ajpath.2009.080953_bib41","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1128\/MCB.16.10.5691","article-title":"Deletion of the carboxyl terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype","volume":"16","author":"Moriggl","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2009.080953_bib42","doi-asserted-by":"crossref","first-page":"29697","DOI":"10.1016\/S0021-9258(18)43936-1","article-title":"Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol","volume":"269","author":"Oliver","year":"1994","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080953_bib43","doi-asserted-by":"crossref","first-page":"12661","DOI":"10.1074\/jbc.275.17.12661","article-title":"Distinct mechanisms of STAT phosphorylation via the interferon-alpha\/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol","volume":"275","author":"Su","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080953_bib44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1439-0264.2002.00398.x","article-title":"Morphological and biochemical aspects of apoptosis, oncosis and necrosis","volume":"31","author":"Van Cruchten","year":"2002","journal-title":"Anat Histol Embryol"},{"key":"10.2353\/ajpath.2009.080953_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1084\/jem.20042541","article-title":"Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis","volume":"202","author":"Kato","year":"2005","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2009.080953_bib46","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.191.6.977","article-title":"Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL","volume":"191","author":"Horita","year":"2000","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2009.080953_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/shem.2003.50034","article-title":"Molecular mechanisms of transformation by the BCR-ABL oncogene","volume":"40","author":"Sattler","year":"2003","journal-title":"Semin Hematol"},{"key":"10.2353\/ajpath.2009.080953_bib48","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood.V95.6.2118","article-title":"STAT5 activation contributes to growth and viability in Bcr\/Abl-transformed cells","volume":"95","author":"Sillaber","year":"2000","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib49","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1182\/blood.V85.3.790.bloodjournal853790","article-title":"Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines","volume":"85","author":"Kitayama","year":"1995","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib50","first-page":"189","article-title":"Transforming and differentiation-inducing potential of constitutively activated c-kit mutant genes in the IC-2 murine interleukin-3-dependent mast cell line","volume":"148","author":"Hashimoto","year":"1996","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2009.080953_bib51","first-page":"1115","article-title":"Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant","volume":"1","author":"Frost","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"10.2353\/ajpath.2009.080953_bib52","doi-asserted-by":"crossref","first-page":"16965","DOI":"10.1074\/jbc.274.24.16965","article-title":"STAT protein recruitment and activation in c-Kit deletion mutants","volume":"274","author":"Brizzi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2009.080953_bib53","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood-2002-01-0203","article-title":"Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene","volume":"100","author":"Yavuz","year":"2002","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib54","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2005.02.030","article-title":"Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature","volume":"115","author":"Kocabas","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.2353\/ajpath.2009.080953_bib55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.0960-135X.2004.01369.x","article-title":"On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts","volume":"34","author":"Valent","year":"2004","journal-title":"Eur J Clin Invest"},{"key":"10.2353\/ajpath.2009.080953_bib56","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1182\/blood-2004-12-4617","article-title":"Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412","volume":"106","author":"Growney","year":"2005","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib57","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1182\/blood-2005-04-1568","article-title":"Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation","volume":"106","author":"Gotlib","year":"2005","journal-title":"Blood"},{"key":"10.2353\/ajpath.2009.080953_bib58","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1158\/0008-5472.CAN-05-2050","article-title":"Dasatinib (BMS-354825), a dual SRC\/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies","volume":"66","author":"Schittenhelm","year":"2006","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2009.080953_bib59","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1182\/blood-2005-10-3969","article-title":"Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis","volume":"108","author":"Shah","year":"2006","journal-title":"Blood"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010607511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010607511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T13:44:57Z","timestamp":1710683097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010607511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0002944010607511"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2009.080953","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}